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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,

Latest revision as of 12:08, 17 September 2013


Full id: C2590_Neural_acute_Corneal_Neurons_Astrocyte_anaplastic_Ciliary



Phase1 CAGE Peaks

Hg19::chr1:50889103..50889145,-p1@DMRTA2
Hg19::chr2:63272179..63272222,+p4@EHBP1
Hg19::chr2:63277948..63277974,+p1@OTX1
Hg19::chr2:63277978..63277995,+p2@OTX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030901midbrain development0.0390620228447837
GO:0042472inner ear morphogenesis0.0390620228447837
GO:0042471ear morphogenesis0.0390620228447837
GO:0048839inner ear development0.0390620228447837
GO:0043583ear development0.0390620228447837
GO:0030900forebrain development0.0390620228447837
GO:0009952anterior/posterior pattern formation0.0390620228447837
GO:0003700transcription factor activity0.0390620228447837
GO:0007548sex differentiation0.0390620228447837
GO:0007423sensory organ development0.0390620228447837
GO:0003002regionalization0.0390620228447837
GO:0003006reproductive developmental process0.0390620228447837
GO:0048598embryonic morphogenesis0.0390620228447837
GO:0007389pattern specification process0.0483183447952316



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell3.49e-17253
endodermal cell6.07e-0958
endo-epithelial cell2.28e-0842
Uber Anatomy
Ontology termp-valuen
pre-chordal neural plate2.76e-2361
telencephalon8.48e-1934
ectoderm-derived structure1.96e-18171
ectoderm1.96e-18171
presumptive ectoderm1.96e-18171
regional part of forebrain2.14e-1841
forebrain2.14e-1841
anterior neural tube2.14e-1841
future forebrain2.14e-1841
regional part of telencephalon9.89e-1832
cerebral hemisphere1.25e-1732
central nervous system1.61e-1781
brain grey matter5.50e-1734
gray matter5.50e-1734
organ system subdivision8.33e-17223
nervous system9.80e-1789
brain1.30e-1568
future brain1.30e-1568
neurectoderm1.39e-1586
ecto-epithelium1.54e-15104
cerebral cortex2.05e-1525
pallium2.05e-1525
neural plate2.83e-1482
presumptive neural plate2.83e-1482
regional part of nervous system1.62e-1353
regional part of brain1.62e-1353
regional part of cerebral cortex6.06e-1322
neocortex4.76e-1220
neural tube5.51e-1256
neural rod5.51e-1256
future spinal cord5.51e-1256
neural keel5.51e-1256
anatomical cluster6.22e-08373
pigment epithelium of eye7.21e-0811
sense organ7.33e-0824
sensory system7.33e-0824
entire sense organ system7.33e-0824
organ part1.38e-07218
eye5.84e-0721
visual system5.84e-0721
Disease
Ontology termp-valuen
cell type cancer3.87e-25143
cancer1.70e-23235
disease of cellular proliferation5.10e-23239
carcinoma7.63e-22106
organ system cancer7.42e-08137
adenocarcinoma1.06e-0725
disease of anatomical entity9.25e-0739


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.12.70115
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.11.52107
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.118.0498
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.24.29465
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.11.53138
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.26.45898
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
PBX3#5090210.95725634337210.01174530180688030.0428500218468151
RDBP#7936276.81920199501250.0002517810050617040.00271090272037519
SP2#6668213.07676524692230.008330036536614940.0328108876427504



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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