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{{Coexpression_clusters
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|full_id=C2529_Mesenchymal_Corneal_Urothelial_Cardiac_salivary_Sebocyte_Esophageal
|id=C2529
|ontology_enrichment_celltype=CL:0000220!3.45e-37!246;CL:0002321!5.65e-37!248;CL:0000055!1.14e-31!180;CL:0000222!2.98e-25!119;CL:0000183!1.21e-18!59;CL:0000680!2.00e-17!57;CL:0000056!2.00e-17!57;CL:0000355!2.00e-17!57;CL:0000187!2.14e-16!54;CL:0000393!2.12e-14!60;CL:0000211!2.12e-14!60;CL:0000192!3.93e-14!42;CL:0000514!3.93e-14!42;CL:0000057!1.65e-13!75;CL:0000144!2.45e-13!625;CL:0000548!2.61e-13!679;CL:0000004!2.61e-13!679;CL:0000255!2.61e-13!679;CL:0000066!1.01e-12!254;CL:0000012!1.25e-12!682;CL:0002371!1.23e-11!591;CL:0000359!1.96e-11!32;CL:0000213!5.29e-09!57;CL:0000215!5.29e-09!57;CL:0000221!1.12e-07!71;CL:0000076!2.31e-07!62
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000475!4.90e-25!365;UBERON:0000119!5.42e-23!312;UBERON:0005256!1.10e-22!143;UBERON:0000483!1.41e-22!309;UBERON:0000486!9.39e-22!82;UBERON:0002100!2.14e-21!216;UBERON:0000481!4.08e-20!347;UBERON:0000914!2.13e-19!83;UBERON:0002329!2.13e-19!83;UBERON:0003077!2.13e-19!83;UBERON:0003059!2.13e-19!83;UBERON:0007282!2.13e-19!83;UBERON:0009618!2.13e-19!83;UBERON:0007285!2.13e-19!83;UBERON:0002049!7.41e-19!79;UBERON:0007798!7.41e-19!79;UBERON:0003104!4.73e-18!238;UBERON:0009142!4.73e-18!238;UBERON:0003914!1.45e-17!118;UBERON:0004290!1.62e-17!70;UBERON:0000490!7.28e-17!138;UBERON:0004872!9.03e-16!84;UBERON:0000055!1.71e-15!69;UBERON:0000468!1.84e-15!659;UBERON:0001134!2.32e-15!61;UBERON:0002036!2.32e-15!61;UBERON:0003082!2.32e-15!61;UBERON:0002385!1.96e-14!63;UBERON:0001015!1.96e-14!63;UBERON:0000383!1.96e-14!63;UBERON:0001981!3.14e-14!60;UBERON:0007500!3.14e-14!60;UBERON:0004537!3.14e-14!60;UBERON:0006965!3.14e-14!60;UBERON:0000477!5.10e-14!286;UBERON:0000480!7.52e-13!626;UBERON:0000467!8.30e-13!625;UBERON:0001637!8.56e-13!42;UBERON:0003509!8.56e-13!42;UBERON:0004572!8.56e-13!42;UBERON:0003102!1.17e-12!95;UBERON:0004535!1.31e-12!110;UBERON:0001009!9.24e-12!113;UBERON:0004111!9.63e-12!241;UBERON:0000922!1.45e-11!612;UBERON:0002050!1.89e-11!605;UBERON:0005423!1.89e-11!605;UBERON:0000923!2.03e-11!604;UBERON:0005291!2.03e-11!604;UBERON:0006598!2.03e-11!604;UBERON:0002532!2.03e-11!604;UBERON:0004573!1.77e-10!33;UBERON:0004571!1.77e-10!33;UBERON:0005085!3.16e-08!29;UBERON:0001048!5.49e-08!168;UBERON:0002199!8.23e-08!45;UBERON:0002416!8.23e-08!45;UBERON:0000025!9.62e-08!194;UBERON:0009569!4.12e-07!113;UBERON:0001444!5.13e-07!48;UBERON:0002097!9.50e-07!40
}}

Latest revision as of 12:07, 17 September 2013


Full id: C2529_Mesenchymal_Corneal_Urothelial_Cardiac_salivary_Sebocyte_Esophageal



Phase1 CAGE Peaks

Hg19::chr1:154943142..154943157,-p3@SHC1
Hg19::chr1:154943181..154943192,-p4@SHC1
Hg19::chr1:154943212..154943230,-p1@SHC1
Hg19::chr1:154943232..154943245,-p5@SHC1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
organism subdivision7.44e-24264
multilaminar epithelium3.69e-2283
cell layer7.19e-22309
epithelium1.66e-21306
mesenchyme1.96e-21160
entire embryonic mesenchyme1.96e-21160
epithelial vesicle5.08e-2178
trunk mesenchyme5.36e-20122
trunk4.15e-19199
unilaminar epithelium5.31e-19148
vasculature1.27e-1878
vascular system1.27e-1878
somite9.69e-1871
presomitic mesoderm9.69e-1871
presumptive segmental plate9.69e-1871
dermomyotome9.69e-1871
trunk paraxial mesoderm9.69e-1871
epithelial tube2.04e-17117
multi-tissue structure2.48e-17342
dense mesenchyme tissue2.71e-1773
paraxial mesoderm3.40e-1772
presumptive paraxial mesoderm3.40e-1772
anatomical cluster2.82e-16373
multi-cellular organism9.43e-16656
skeletal muscle tissue1.18e-1562
striated muscle tissue1.18e-1562
myotome1.18e-1562
splanchnic layer of lateral plate mesoderm2.34e-1583
vessel4.87e-1568
muscle tissue9.06e-1564
musculature9.06e-1564
musculature of body9.06e-1564
anatomical system2.79e-14624
anatomical group2.82e-14625
epithelial tube open at both ends8.67e-1459
blood vessel8.67e-1459
blood vasculature8.67e-1459
vascular cord8.67e-1459
surface structure1.07e-1399
cardiovascular system1.06e-12109
artery1.11e-1242
arterial blood vessel1.11e-1242
arterial system1.11e-1242
circulatory system7.11e-12112
anatomical conduit2.73e-11240
systemic artery1.95e-1033
systemic arterial system1.95e-1033
embryo1.72e-09592
integument9.92e-0946
integumental system9.92e-0946
developing anatomical structure1.00e-08581
ectodermal placode4.99e-0831
embryonic structure7.05e-08564
skin of body1.27e-0741
germ layer1.68e-07560
germ layer / neural crest1.68e-07560
embryonic tissue1.68e-07560
presumptive structure1.68e-07560
germ layer / neural crest derived structure1.68e-07560
epiblast (generic)1.68e-07560
tube2.01e-07192
primordium2.22e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.11.65296
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.12.80052
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.15.01475
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.11.4709
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.12.05499
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.8309
MA0147.10.46175
MA0148.11.75269
MA0149.15.7925
MA0062.21.66396
MA0035.20.778873
MA0039.25.64763
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.24.07926
MA0150.13.7809
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.12.64806
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.13.83423
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.21.85039
MA0079.29.35212
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235348.99795530889440.0001525147711168630.00194915445186907
FOSL2#2355416.93020060456171.2165416097647e-050.000303957868856975
FOXA1#3169411.08141974938556.62943068949433e-050.00107161602194722
FOXA2#3170424.63046375266522.71504128667089e-069.44243080048687e-05
GATA2#2624412.7449317335543.78864877853583e-050.00072191696730798
GTF2B#2959431.94382993432429.59435337635006e-074.08822795704865e-05
HEY1#2346244.040111043105710.00375304636917980.0186144469654162
JUND#372746.994663941871030.000417684217818580.00391795599288258
MAFK#7975427.10073313782991.85228494563408e-066.855095231647e-05
REST#597849.650028716128020.0001152825614219170.00157098061486738
TAF1#687243.343046285745290.008005664898701650.0322359423354861
TAF7#6879411.43306940492395.85061525419808e-050.000969431074937638
TBP#690843.706770687096390.005296377814784350.0244323499380858
ZBTB7A#5134147.35190930787590.000342223540015990.00346701758616063



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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