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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 12:02, 17 September 2013


Full id: C2281_hairy_CD19_b_vein_appendix_lymph_tonsil



Phase1 CAGE Peaks

Hg19::chr14:106114704..106114716,-p1@ENST00000460164
Hg19::chr14:106114739..106114746,-p2@ENST00000460164
Hg19::chr21:42602057..42602083,+p7@BACE2
Hg19::chr2:89161064..89161082,-p1@IGKJ2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042985negative regulation of amyloid precursor protein biosynthetic process0.00231808548216178
GO:0042983amyloid precursor protein biosynthetic process0.00231808548216178
GO:0042984regulation of amyloid precursor protein biosynthetic process0.00231808548216178
GO:0009049aspartic-type signal peptidase activity0.00231808548216178
GO:0016486peptide hormone processing0.00259625574002119
GO:0009003signal peptidase activity0.00288472860002355
GO:0033619membrane protein proteolysis0.00288472860002355
GO:0006509membrane protein ectodomain proteolysis0.00288472860002355
GO:0042982amyloid precursor protein metabolic process0.00288472860002355
GO:0050435beta-amyloid metabolic process0.00315259625574002
GO:0004194pepsin A activity0.00438328891172409
GO:0009306protein secretion0.00880872483221476
GO:0004190aspartic-type endopeptidase activity0.011656658424585
GO:0042445hormone metabolic process0.011656658424585
GO:0016485protein processing0.0122394913458142
GO:0009101glycoprotein biosynthetic process0.0200718931161302
GO:0006417regulation of translation0.0200718931161302
GO:0031326regulation of cellular biosynthetic process0.0201209819851642
GO:0009100glycoprotein metabolic process0.0201209819851642
GO:0009889regulation of biosynthetic process0.0201209819851642
GO:0032940secretion by cell0.0262274814553161
GO:0046903secretion0.0323689027327318
GO:0051246regulation of protein metabolic process0.0340254634251225



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
blood6.75e-1715
haemolymphatic fluid6.75e-1715
organism substance6.75e-1715
hemopoietic organ1.65e-147
immune organ1.65e-147
spleen2.71e-133
gastrointestinal system mesentery2.71e-133
stomach region2.71e-133
mesentery2.71e-133
gastrointestinal system serosa2.71e-133
mesentery of stomach2.71e-133
gut mesentery2.71e-133
dorsal mesentery2.71e-133
dorsal mesogastrium2.71e-133
peritoneal cavity2.71e-133
spleen primordium2.71e-133
adult organism6.68e-10114
hemolymphoid system3.20e-07108
gastrointestinal system5.75e-0725
Disease
Ontology termp-valuen
lymphoma8.50e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.12.48281
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.93422
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.11.57689
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.11.46638
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.12.59564
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.11.61785
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.20.0021048
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360129297448237



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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