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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:59, 17 September 2013


Full id: C2151_CD4_CD19_CD8_Whole_Dendritic_Neutrophils_Eosinophils



Phase1 CAGE Peaks

Hg19::chr11:64107543..64107574,-p@chr11:64107543..64107574
-
Hg19::chr16:30195531..30195557,+p@chr16:30195531..30195557
+
Hg19::chr16:30195571..30195586,+p@chr16:30195571..30195586
+
Hg19::chr16:3179653..3179678,-p@chr16:3179653..3179678
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell1.26e-78168
angioblastic mesenchymal cell1.26e-78168
leukocyte7.84e-77136
hematopoietic cell4.34e-76177
hematopoietic oligopotent progenitor cell4.90e-72161
hematopoietic multipotent progenitor cell4.90e-72161
nongranular leukocyte5.63e-64115
hematopoietic lineage restricted progenitor cell1.09e-63120
nucleate cell1.24e-4555
lymphocyte7.16e-4553
common lymphoid progenitor7.16e-4553
lymphoid lineage restricted progenitor cell2.38e-4452
myeloid cell2.71e-28108
common myeloid progenitor2.71e-28108
myeloid leukocyte7.68e-2472
T cell2.54e-2125
pro-T cell2.54e-2125
lymphocyte of B lineage6.22e-2124
pro-B cell6.22e-2124
classical monocyte2.41e-2042
CD14-positive, CD16-negative classical monocyte2.41e-2042
myeloid lineage restricted progenitor cell4.49e-2066
granulocyte monocyte progenitor cell1.26e-1967
macrophage dendritic cell progenitor3.16e-1961
mature alpha-beta T cell9.94e-1918
alpha-beta T cell9.94e-1918
immature T cell9.94e-1918
mature T cell9.94e-1918
immature alpha-beta T cell9.94e-1918
monopoietic cell2.62e-1859
monocyte2.62e-1859
monoblast2.62e-1859
promonocyte2.62e-1859
defensive cell3.17e-1648
phagocyte3.17e-1648
mesenchymal cell1.06e-14354
connective tissue cell1.09e-13361
B cell1.17e-1314
CD8-positive, alpha-beta T cell3.59e-1211
motile cell2.94e-10386
intermediate monocyte1.01e-079
CD14-positive, CD16-positive monocyte1.01e-079
CD4-positive, alpha-beta T cell2.94e-076
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.64e-3398
blood island5.64e-3398
hemolymphoid system5.31e-30108
immune system1.20e-1993
bone marrow1.68e-1776
bone element4.74e-1582
blood9.78e-1415
haemolymphatic fluid9.78e-1415
organism substance9.78e-1415
skeletal element2.35e-1290
connective tissue2.45e-12371
skeletal system3.31e-10100
lateral plate mesoderm4.70e-07203
hemopoietic organ7.32e-077
immune organ7.32e-077
Disease
Ontology termp-valuen
hematologic cancer3.40e-1251
immune system cancer3.40e-1251
leukemia1.70e-0839
lymphoma8.57e-0710


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.11.35734
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.12.54366
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.13.20115
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.866596
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.21.13403
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.26.77569
MA0065.23.22574
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.12.03616
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.253219
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.21.11128
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335214.18472755180350.007108328585298740.0296137352554954
BCL3#602217.27355140186920.004834494208076070.022670157174805
EBF1#187936.679850134926750.005184294118278910.0240331347782383
ELF1#199744.258097958807540.003041525565781240.0160569119225915
GABPB1#255347.067683836182170.0004006876864423170.00389785965763311
IRF4#3662210.95725634337210.01174530180688030.0428171166675547
NFKB1#479045.488063424193840.001102199566301980.00766548714823282
PAX5#507946.669565531177830.0005052774169483260.00443115863201496
POU2F2#545236.829593043306890.004860473775203740.0227531609416631
SPI1#668848.204323508522730.000220661881527680.00249061993352095
TCF12#6938410.63446490218647.8163066689251e-050.00119889448112185
YY1#752844.911170749853860.00171871838055440.0106630170456648
ZEB1#6935312.66632401315790.000793336075912850.00612925184437507



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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