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{{Coexpression_clusters
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|full_id=C2032_splenic_hairy_plasma_CD19_B_xeroderma_tonsil
|id=C2032
|ontology_enrichment_celltype=CL:0000945!2.29e-56!24;CL:0000826!2.29e-56!24;CL:0000236!7.92e-34!14;CL:0000542!9.96e-26!53;CL:0000051!9.96e-26!53;CL:0000838!3.26e-24!52;CL:0002087!7.26e-17!119;CL:0000738!7.44e-16!140;CL:0000988!1.07e-15!182;CL:0000037!1.84e-14!172;CL:0000566!1.84e-14!172;CL:0002031!1.12e-13!124;CL:0002032!8.33e-13!165;CL:0000837!8.33e-13!165;CL:0000080!6.32e-09!6;CL:0000817!7.35e-08!3
|ontology_enrichment_disease=DOID:0060058!3.86e-11!10;DOID:2531!6.27e-07!51;DOID:0060083!6.27e-07!51
|ontology_enrichment_uberon=UBERON:0007023!1.89e-16!115;UBERON:0001869!1.05e-09!32;UBERON:0002619!1.74e-09!22;UBERON:0001893!5.69e-09!34;UBERON:0001950!1.06e-08!20;UBERON:0000178!2.23e-08!15;UBERON:0000179!2.23e-08!15;UBERON:0000463!2.23e-08!15;UBERON:0002106!3.04e-08!3;UBERON:0004854!3.04e-08!3;UBERON:0009034!3.04e-08!3;UBERON:0002095!3.04e-08!3;UBERON:0004782!3.04e-08!3;UBERON:0003281!3.04e-08!3;UBERON:0009664!3.04e-08!3;UBERON:0002296!3.04e-08!3;UBERON:0005602!3.04e-08!3;UBERON:0001179!3.04e-08!3;UBERON:0006293!3.04e-08!3;UBERON:0000956!4.00e-08!25;UBERON:0000203!4.00e-08!25;UBERON:0002780!4.43e-08!41;UBERON:0001890!4.43e-08!41;UBERON:0006240!4.43e-08!41;UBERON:0002791!5.25e-08!33;UBERON:0003080!8.15e-08!42;UBERON:0002020!1.07e-07!34;UBERON:0003528!1.07e-07!34;UBERON:0001049!1.29e-07!57;UBERON:0005068!1.29e-07!57;UBERON:0006241!1.29e-07!57;UBERON:0007135!1.29e-07!57;UBERON:0001871!5.07e-07!7
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}}

Latest revision as of 11:57, 17 September 2013


Full id: C2032_splenic_hairy_plasma_CD19_B_xeroderma_tonsil



Phase1 CAGE Peaks

Hg19::chr10:103649352..103649390,-p5@C10orf76
Hg19::chr21:16135576..16135586,-p@chr21:16135576..16135586
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Hg19::chr2:231454365..231454375,-p@chr2:231454365..231454375
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Hg19::chr2:231454377..231454382,-p@chr2:231454377..231454382
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
spleen4.12e-203
gastrointestinal system mesentery4.12e-203
stomach region4.12e-203
mesentery4.12e-203
gastrointestinal system serosa4.12e-203
mesentery of stomach4.12e-203
gut mesentery4.12e-203
dorsal mesentery4.12e-203
dorsal mesogastrium4.12e-203
peritoneal cavity4.12e-203
spleen primordium4.12e-203
hemopoietic organ6.39e-097
immune organ6.39e-097
tonsil6.52e-081
mucosa-associated lymphoid tissue6.52e-081
lymphoid tissue6.52e-081
tonsillar ring6.52e-081
stomach7.31e-088
food storage organ7.31e-088
vermiform appendix1.11e-071
caecum1.11e-071
midgut1.11e-071
insula1.99e-071
Disease
Ontology termp-valuen
lymphoma1.87e-1010
genetic disease6.10e-081
monogenic disease6.10e-081
xeroderma pigmentosum6.10e-081
bone marrow cancer9.72e-081
myeloma9.72e-081
acute leukemia1.26e-071
anemia1.64e-071


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.12.80362
MA0051.13.18613
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.12.63991
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.12.01976
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.13.39971
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.22.27911
MA0018.20.870662
MA0099.21.85039
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538318.26835134422770.0002681660105721290.00286545835667512
BCL11A#53335321.27709132770530.0001704839114606140.00208028615831698
BCL3#602217.27355140186920.004834494208076070.0226681216035403
BCLAF1#9774210.82632380506090.01202203816432580.0436355614041851
IRF4#3662316.43588451505810.0003669431395554610.00365609373707621
MEF2A#4205418.74323090964418.0978922767748e-060.000224095328959746
MEF2C#4208220.6556772463120.003402570579445040.0173533093440112
PAX5#507935.002174148383370.01196533174786410.0434644806238105
PBX3#5090210.95725634337210.01174530180688030.0428051636741032
RAD21#588537.766275421592250.0033411193858720.0172581812919079
REST#597837.237521537096020.004104697304192610.019565973608059
RXRA#6256210.03730856956660.01391703805920110.0488663776850761
SPI1#668836.153242631392040.006580387113059030.028086519665731
TCF12#693837.975848676639820.003090920396013070.0162691581110376
ZNF143#7702310.12565741417090.001534861610688180.00975947712381512



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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