MCL coexpression mm9:954

Phase1 CAGE Peaks

	Short description
Mm9::chr14:14845141..14845207,+	p1@Atxn7
Mm9::chr15:12134823..12134874,+	p1@Mtmr12
Mm9::chr16:33185131..33185239,+	p1@Osbpl11
Mm9::chr17:28828364..28828390,+	p1@Mapk14
Mm9::chr18:38095057..38095082,-	p1@Diap1
Mm9::chr18:38095083..38095104,-	p2@Diap1
Mm9::chr18:62708375..62708419,-	p2@Fbxo38
Mm9::chr1:193220446..193220471,-	p3@Ppp2r5a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008339	MP kinase activity	0.0484639325624417
GO:0032494	response to peptidoglycan	0.0484639325624417
GO:0032495	response to muramyl dipeptide	0.0484639325624417
GO:0016909	SAP kinase activity	0.0484639325624417
GO:0045648	positive regulation of erythrocyte differentiation	0.0484639325624417

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	2.52e-16	118
endoderm	2.52e-16	118
presumptive endoderm	2.52e-16	118
digestive system	3.36e-16	116
digestive tract	3.36e-16	116
primitive gut	3.36e-16	116
subdivision of digestive tract	4.53e-16	114
endo-epithelium	2.29e-12	69
gut epithelium	8.94e-11	55
unilaminar epithelium	6.25e-10	66
foregut	2.24e-09	80
hemolymphoid system	7.25e-08	48
immune system	7.25e-08	48
mixed endoderm/mesoderm-derived structure	1.87e-07	35
hematopoietic system	2.20e-07	45
blood island	2.20e-07	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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