Coexpression cluster:C711

Full id: C711_cerebellum_Pericytes_Fibroblast_Meningeal_spinal_Astrocyte_Hair

Phase1 CAGE Peaks

Hg19::chr3:147114993..147115013,-	p5@ZIC4
Hg19::chr3:147115338..147115349,+	p@chr3:147115338..147115349 +
Hg19::chr3:147115400..147115411,+	p@chr3:147115400..147115411 +
Hg19::chr3:147126815..147126825,-	p@chr3:147126815..147126825 -
Hg19::chr3:147127177..147127194,+	p2@ZIC1
Hg19::chr3:147129975..147129992,+	p@chr3:147129975..147129992 +
Hg19::chr3:147130332..147130352,+	p@chr3:147130332..147130352 +
Hg19::chr3:147131290..147131301,+	p@chr3:147131290..147131301 +
Hg19::chr3:147137194..147137222,+	p1@FLJ30375
Hg19::chr3:147139053..147139112,+	p5@ZIC1
Hg19::chr3:147139152..147139163,+	p15@ZIC1
Hg19::chr3:147139238..147139247,+	p26@ZIC1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008589	regulation of smoothened signaling pathway	0.0197690591558547
GO:0007224	smoothened signaling pathway	0.0197690591558547
GO:0042472	inner ear morphogenesis	0.0197690591558547
GO:0042471	ear morphogenesis	0.0197690591558547
GO:0048839	inner ear development	0.0197690591558547
GO:0043583	ear development	0.0197690591558547
GO:0007423	sensory organ development	0.0328060999854834
GO:0048598	embryonic morphogenesis	0.0328060999854834
GO:0007389	pattern specification process	0.0388635391999214
GO:0007420	brain development	0.0391996244308409
GO:0003677	DNA binding	0.0464642615688377

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
astrocyte of the cerebellum	4.13e-09	3
hair follicle cell	4.34e-09	5
leptomeningeal cell	4.35e-09	3
ciliated cell	4.84e-09	3
ciliated epithelial cell	4.84e-09	3
multi-ciliated epithelial cell	4.84e-09	3
non-pigmented ciliary epithelial cell	4.84e-09	3
oligodendrocyte	5.07e-09	7
macroglial cell	5.07e-09	7
astrocyte	5.07e-09	7
oligodendrocyte precursor cell	5.07e-09	7
smooth muscle cell of the brain vasculature	2.77e-08	3
central nervous system pericyte	7.57e-07	2

Uber Anatomy

Ontology term	p-value	n
central nervous system	2.68e-68	81
neural tube	1.83e-65	56
neural rod	1.83e-65	56
future spinal cord	1.83e-65	56
neural keel	1.83e-65	56
brain	7.75e-63	68
future brain	7.75e-63	68
nervous system	3.21e-60	89
neural plate	1.77e-59	82
presumptive neural plate	1.77e-59	82
regional part of nervous system	8.89e-59	53
regional part of brain	8.89e-59	53
neurectoderm	4.07e-56	86
ecto-epithelium	9.33e-54	104
ectoderm-derived structure	1.79e-42	171
ectoderm	1.79e-42	171
presumptive ectoderm	1.79e-42	171
structure with developmental contribution from neural crest	3.42e-41	132
posterior neural tube	1.21e-36	15
chordal neural plate	1.21e-36	15
pre-chordal neural plate	1.07e-35	61
regional part of forebrain	1.09e-33	41
forebrain	1.09e-33	41
anterior neural tube	1.09e-33	41
future forebrain	1.09e-33	41
segmental subdivision of hindbrain	1.39e-29	12
hindbrain	1.39e-29	12
presumptive hindbrain	1.39e-29	12
segmental subdivision of nervous system	4.56e-27	13
telencephalon	3.63e-26	34
brain grey matter	4.07e-26	34
gray matter	4.07e-26	34
adult organism	2.12e-23	114
regional part of metencephalon	7.36e-23	9
metencephalon	7.36e-23	9
future metencephalon	7.36e-23	9
regional part of telencephalon	8.17e-23	32
cerebral hemisphere	1.33e-22	32
cell layer	2.79e-20	309
organ system subdivision	3.83e-20	223
vasculature of organ	2.50e-18	11
epithelium	1.22e-17	306
cerebellum	6.03e-17	6
rhombic lip	6.03e-17	6
cerebral cortex	4.27e-16	25
pallium	4.27e-16	25
brainstem	2.19e-14	6
regional part of cerebral cortex	7.43e-14	22
brain vasculature	2.80e-13	5
neocortex	5.56e-13	20
multi-tissue structure	2.23e-12	342
neural nucleus	3.33e-12	9
nucleus of brain	3.33e-12	9
anatomical cluster	1.13e-11	373
tube	2.25e-11	192
atypical epithelium	2.77e-11	4
regional part of diencephalon	4.87e-11	4
organ part	2.53e-10	218
diencephalon	4.19e-09	7
future diencephalon	4.19e-09	7
hair follicle	4.34e-09	5
hair follicle placode	4.34e-09	5
blood-cerebrospinal fluid barrier	4.35e-09	3
basal ganglion	4.69e-09	9
nuclear complex of neuraxis	4.69e-09	9
aggregate regional part of brain	4.69e-09	9
collection of basal ganglia	4.69e-09	9
cerebral subcortex	4.69e-09	9
ciliary epithelium	4.84e-09	3
ciliary body	4.84e-09	3
spinal cord	1.06e-08	3
dorsal region element	1.06e-08	3
dorsum	1.06e-08	3
telencephalic nucleus	1.50e-08	7
medulla oblongata	2.10e-08	3
myelencephalon	2.10e-08	3
future myelencephalon	2.10e-08	3
pigment epithelium of eye	3.78e-08	11
ectodermal placode	5.52e-08	31
occipital lobe	7.49e-08	5
pons	1.15e-07	3
vasculature of eye	1.73e-07	6
uvea	1.73e-07	6
vasculature of head	1.73e-07	6
germ layer	2.35e-07	560
germ layer / neural crest	2.35e-07	560
embryonic tissue	2.35e-07	560

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTBP2#1488	4	20.905666779776	2.88227050924922e-05	0.000603733352818851
SUZ12#23512	9	37.5868356832972	1.0350112335066e-13	1.620622761862e-11

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.