Coexpression cluster:C3554

Full id: C3554_acute_myelodysplastic_Natural_chronic_Basophils_CD8_CD133

Phase1 CAGE Peaks

Hg19::chr16:29674246..29674275,+	p3@SPN
Hg19::chr16:29674277..29674306,+	p2@SPN
Hg19::chr16:29674323..29674335,+	p8@SPN

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	1.22e-72	168
angioblastic mesenchymal cell	1.22e-72	168
hematopoietic cell	3.01e-69	177
hematopoietic oligopotent progenitor cell	8.32e-67	161
hematopoietic multipotent progenitor cell	8.32e-67	161
leukocyte	7.22e-46	136
hematopoietic lineage restricted progenitor cell	6.98e-40	120
myeloid cell	1.08e-39	108
common myeloid progenitor	1.08e-39	108
nongranular leukocyte	1.32e-36	115
nucleate cell	1.77e-24	55
lymphocyte	2.18e-23	53
common lymphoid progenitor	2.18e-23	53
T cell	9.87e-23	25
pro-T cell	9.87e-23	25
lymphoid lineage restricted progenitor cell	1.03e-22	52
mature alpha-beta T cell	1.30e-18	18
alpha-beta T cell	1.30e-18	18
immature T cell	1.30e-18	18
mature T cell	1.30e-18	18
immature alpha-beta T cell	1.30e-18	18
myeloid leukocyte	3.01e-17	72
myeloid lineage restricted progenitor cell	9.59e-16	66
granulocyte monocyte progenitor cell	1.02e-15	67
mesenchymal cell	1.68e-14	354
connective tissue cell	1.40e-13	361
CD8-positive, alpha-beta T cell	2.17e-13	11
macrophage dendritic cell progenitor	6.33e-13	61
monopoietic cell	1.16e-11	59
monocyte	1.16e-11	59
monoblast	1.16e-11	59
promonocyte	1.16e-11	59
motile cell	8.74e-11	386
classical monocyte	8.46e-08	42
CD14-positive, CD16-negative classical monocyte	8.46e-08	42
intermediate monocyte	1.47e-07	9
CD14-positive, CD16-positive monocyte	1.47e-07	9
defensive cell	1.69e-07	48
phagocyte	1.69e-07	48
stem cell	3.63e-07	441
multi fate stem cell	4.08e-07	427

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	2.52e-27	98
blood island	2.52e-27	98
hemolymphoid system	5.58e-25	108
immune system	6.72e-16	93
bone marrow	1.96e-13	76
connective tissue	8.89e-13	371
blood	9.68e-13	15
haemolymphatic fluid	9.68e-13	15
organism substance	9.68e-13	15
bone element	1.51e-11	82
skeletal element	1.77e-09	90
skeletal system	6.46e-08	100
hemopoietic organ	3.58e-07	7
immune organ	3.58e-07	7

Disease

Ontology term	p-value	n
hematologic cancer	1.38e-33	51
immune system cancer	1.38e-33	51
leukemia	2.09e-33	39
myeloid leukemia	3.27e-28	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BCL11A#53335	3	28.3694551036071	4.37778126761649e-05	0.000777437676940313
EBF1#1879	3	8.906466846569	0.0014152328356098	0.00914128901714715
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0320025697771257
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0461363931139631
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0269259882136566
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.017268793686665
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0246090721463381
SPI1#6688	3	8.20432350852273	0.00181059318941052	0.0108983080000487
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0328753087386029
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0139933570709276

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.