Coexpression cluster:C1765

Full id: C1765_Renal_Hepatic_Endothelial_placenta_Lymphatic_breast_lung

Phase1 CAGE Peaks

Hg19::chr16:67224002..67224047,-	p1@EXOC3L1
Hg19::chr19:17375527..17375538,-	p2@USHBP1
Hg19::chr5:180076580..180076605,-	p1@FLT4
Hg19::chr5:180076613..180076634,-	p2@FLT4
Hg19::chr9:80263579..80263618,-	p2@GNA14

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048010	vascular endothelial growth factor receptor signaling pathway	0.0435920646625478
GO:0030165	PDZ domain binding	0.0435920646625478
GO:0005021	vascular endothelial growth factor receptor activity	0.0435920646625478
GO:0006471	protein amino acid ADP-ribosylation	0.0435920646625478
GO:0005834	heterotrimeric G-protein complex	0.0496118168482225

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell	3.50e-25	36
endothelial cell of vascular tree	3.25e-24	24
meso-epithelial cell	4.50e-18	45
blood vessel endothelial cell	1.83e-16	18
embryonic blood vessel endothelial progenitor cell	1.83e-16	18
lining cell	1.03e-12	58
barrier cell	1.03e-12	58
lymphangioblast	1.41e-09	6
endothelial cell of lymphatic vessel	1.41e-09	6
vascular lymphangioblast	1.41e-09	6
vein endothelial cell	1.14e-08	6

Uber Anatomy

Ontology term	p-value	n
adult organism	4.14e-56	114
anatomical conduit	8.33e-23	240
anatomical cluster	7.12e-21	373
tube	1.00e-19	192
neural tube	5.61e-18	56
neural rod	5.61e-18	56
future spinal cord	5.61e-18	56
neural keel	5.61e-18	56
blood vessel endothelium	1.83e-16	18
endothelium	1.83e-16	18
cardiovascular system endothelium	1.83e-16	18
regional part of nervous system	7.37e-16	53
regional part of brain	7.37e-16	53
regional part of forebrain	9.05e-15	41
forebrain	9.05e-15	41
anterior neural tube	9.05e-15	41
future forebrain	9.05e-15	41
brain grey matter	4.01e-14	34
gray matter	4.01e-14	34
telencephalon	5.42e-14	34
central nervous system	1.44e-13	81
cerebral hemisphere	1.01e-12	32
regional part of telencephalon	1.06e-12	32
neural plate	1.47e-12	82
presumptive neural plate	1.47e-12	82
simple squamous epithelium	1.65e-12	22
neurectoderm	1.87e-11	86
multi-cellular organism	3.42e-11	656
regional part of cerebral cortex	3.90e-11	22
nervous system	4.39e-11	89
organ system subdivision	5.00e-11	223
neocortex	6.26e-11	20
brain	9.61e-11	68
future brain	9.61e-11	68
structure with developmental contribution from neural crest	1.00e-10	132
squamous epithelium	2.11e-10	25
cell layer	1.01e-09	309
epithelium	1.29e-09	306
vessel	2.46e-09	68
cerebral cortex	2.69e-09	25
pallium	2.69e-09	25
anatomical system	8.46e-09	624
anatomical group	1.01e-08	625
lymphoid system	1.01e-08	10
ecto-epithelium	2.77e-08	104
pre-chordal neural plate	2.89e-08	61
embryo	1.08e-07	592
splanchnic layer of lateral plate mesoderm	1.67e-07	83
multi-tissue structure	1.80e-07	342
vein	2.59e-07	9
venous blood vessel	2.59e-07	9
venous system	2.59e-07	9
vasculature	4.46e-07	78
vascular system	4.46e-07	78
lymphatic vessel	7.83e-07	8
lymph vasculature	7.83e-07	8
lymphatic part of lymphoid system	7.83e-07	8
circulatory system	1.00e-06	112

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.