MCL coexpression mm9:313

Phase1 CAGE Peaks

	Short description
Mm9::chr11:87156375..87156383,-	p@chr11:87156375..87156383 -
Mm9::chr12:92812009..92812012,-	p1@ENSMUST00000116715
Mm9::chr16:50420236..50420246,-	p@chr16:50420236..50420246 -
Mm9::chr17:37199615..37199652,+	p9@Gabbr1
Mm9::chr17:57220111..57220144,+	p@chr17:57220111..57220144 +
Mm9::chr17:57221069..57221081,-	p@chr17:57221069..57221081 -
Mm9::chr17:57221131..57221148,-	p@chr17:57221131..57221148 -
Mm9::chr18:31134922..31134933,-	p@chr18:31134922..31134933 -
Mm9::chr18:82754715..82754729,-	p@chr18:82754715..82754729 -
Mm9::chr19:8994922..8994936,+	p3@B3gat3
Mm9::chr1:155756359..155756371,+	p@chr1:155756359..155756371 +
Mm9::chr1:174204853..174204862,-	p@chr1:174204853..174204862 -
Mm9::chr1:174223797..174223808,-	p@chr1:174223797..174223808 -
Mm9::chr2:113632075..113632088,-	p@chr2:113632075..113632088 -
Mm9::chr2:170174741..170174743,-	p@chr2:170174741..170174743 -
Mm9::chr2:180889957..180889998,+	p@chr2:180889957..180889998 +
Mm9::chr4:132999231..132999250,+	p@chr4:132999231..132999250 +
Mm9::chr4:85034722..85034726,+	p@chr4:85034722..85034726 +
Mm9::chr5:108948149..108948160,-	p@chr5:108948149..108948160 -
Mm9::chr5:139494354..139494365,-	p@chr5:139494354..139494365 -
Mm9::chr6:124711353..124711365,-	p@chr6:124711353..124711365 -
Mm9::chr6:124712740..124712754,-	p@chr6:124712740..124712754 -
Mm9::chr6:124716149..124716167,-	p@chr6:124716149..124716167 -
Mm9::chr7:152100513..152100528,-	p@chr7:152100513..152100528 -
Mm9::chr7:25784031..25784038,-	p@chr7:25784031..25784038 -
Mm9::chr8:73279849..73279867,+	p4@Rab3a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048790	maintenance of presynaptic active zone structure	0.00646469073576947
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane	0.00646469073576947
GO:0051602	response to electrical stimulus	0.00646469073576947
GO:0031629	synaptic vesicle fusion to presynaptic membrane	0.00646469073576947
GO:0031338	regulation of vesicle fusion	0.00646469073576947
GO:0050975	sensory perception of touch	0.00646469073576947
GO:0006542	glutamine biosynthetic process	0.00861887926606475
GO:0004356	glutamate-ammonia ligase activity	0.00861887926606475
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	0.00861887926606475
GO:0016211	ammonia ligase activity	0.0105768461489581
GO:0004965	GABA-B receptor activity	0.0105768461489581
GO:0006906	vesicle fusion	0.0119318713726987
GO:0016880	acid-ammonia (or amide) ligase activity	0.0119318713726987
GO:0016188	synaptic vesicle maturation	0.0129251316475187
GO:0003016	respiratory system process	0.0129251316475187
GO:0048488	synaptic vesicle endocytosis	0.0193829176417405
GO:0016079	synaptic vesicle exocytosis	0.0250775914657576
GO:0016050	vesicle organization and biogenesis	0.0251874396635394
GO:0007274	neuromuscular synaptic transmission	0.0251874396635394
GO:0009084	glutamine family amino acid biosynthetic process	0.0251874396635394
GO:0006541	glutamine metabolic process	0.0276739554004592
GO:0017157	regulation of exocytosis	0.0316914421788287
GO:0015020	glucuronosyltransferase activity	0.0319950096254669
GO:0006944	membrane fusion	0.0354944803059186
GO:0048489	synaptic vesicle transport	0.0356206229408446
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	0.0387085213234202
GO:0016917	GABA receptor activity	0.0401355710100174
GO:0009064	glutamine family amino acid metabolic process	0.0413610703076045
GO:0009791	post-embryonic development	0.0413610703076045
GO:0005737	cytoplasm	0.0423500080886129
GO:0008652	amino acid biosynthetic process	0.0436708464995313

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.11e-24	23
neuroblast (sensu Vertebrata)	1.11e-24	23
neural cell	2.41e-17	43
ectodermal cell	8.62e-17	44
neurectodermal cell	8.62e-17	44
neuron	1.92e-15	33
neuronal stem cell	1.92e-15	33
neuroblast	1.92e-15	33
electrically signaling cell	1.92e-15	33
non-terminally differentiated cell	2.28e-14	49
electrically responsive cell	3.30e-12	39
electrically active cell	3.30e-12	39
embryonic cell	4.37e-08	70
neuron of the substantia nigra	9.60e-07	3

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	3.79e-46	54
nervous system	2.62e-45	75
central nervous system	5.81e-45	73
neural tube	2.31e-42	52
neural rod	2.31e-42	52
future spinal cord	2.31e-42	52
neural keel	2.31e-42	52
neurectoderm	1.02e-39	64
neural plate	1.02e-39	64
presumptive neural plate	1.02e-39	64
ectoderm-derived structure	1.62e-39	95
ectoderm	1.62e-39	95
presumptive ectoderm	1.62e-39	95
gray matter	2.33e-37	34
brain	1.54e-34	47
future brain	1.54e-34	47
ecto-epithelium	2.20e-33	73
regional part of brain	3.34e-33	46
brain grey matter	1.50e-29	29
regional part of telencephalon	1.50e-29	29
telencephalon	1.50e-29	29
pre-chordal neural plate	1.43e-27	49
anterior neural tube	1.77e-27	40
regional part of forebrain	3.77e-26	39
forebrain	3.77e-26	39
future forebrain	3.77e-26	39
structure with developmental contribution from neural crest	4.29e-24	92
cerebral cortex	5.32e-21	21
cerebral hemisphere	5.32e-21	21
pallium	5.32e-21	21
regional part of cerebral cortex	9.77e-19	17
occipital lobe	1.06e-16	10
visual cortex	1.06e-16	10
neocortex	1.06e-16	10
posterior neural tube	3.72e-15	12
chordal neural plate	3.72e-15	12
tube	1.98e-13	114
anatomical conduit	7.31e-12	122
spinal cord	2.52e-10	6
dorsal region element	2.52e-10	6
dorsum	2.52e-10	6
organ system subdivision	8.00e-10	194
basal ganglion	1.60e-09	8
nuclear complex of neuraxis	1.60e-09	8
aggregate regional part of brain	1.60e-09	8
collection of basal ganglia	1.60e-09	8
cerebral subcortex	1.60e-09	8
regional part of spinal cord	5.80e-09	5
gray matter of spinal cord	5.80e-09	5
organ part	9.55e-09	99
regional part of midbrain	4.66e-08	4
midbrain	4.66e-08	4
presumptive midbrain	4.66e-08	4
midbrain neural tube	4.66e-08	4
epithelium	1.89e-07	174
anatomical cluster	1.97e-07	244
cell layer	3.04e-07	176
substantia nigra	9.60e-07	3
telencephalic nucleus	9.60e-07	3
midbrain nucleus	9.60e-07	3
neural nucleus	9.60e-07	3
nucleus of brain	9.60e-07	3

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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