Coexpression cluster:C4762

Full id: C4762_Endothelial_Wilms_mature_Renal_endometrioid_Smooth_Lymphatic

Phase1 CAGE Peaks

Hg19::chr8:55370487..55370503,+	p1@SOX17
Hg19::chr8:55370693..55370704,+	p4@SOX17
Hg19::chr8:55370720..55370733,+	p2@SOX17

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
mesodermal cell	7.69e-22	119
endothelial cell of vascular tree	4.59e-19	24
vascular associated smooth muscle cell	1.75e-18	32
endothelial cell	4.44e-17	35
meso-epithelial cell	2.37e-15	44
blood vessel endothelial cell	5.59e-15	18
embryonic blood vessel endothelial progenitor cell	5.59e-15	18
smooth muscle cell	2.31e-13	42
smooth muscle myoblast	2.31e-13	42
lining cell	9.58e-13	57
barrier cell	9.58e-13	57
contractile cell	1.36e-11	59
muscle cell	3.69e-11	54
electrically responsive cell	2.86e-10	60
electrically active cell	2.86e-10	60
muscle precursor cell	3.23e-10	57
myoblast	3.23e-10	57
multi-potent skeletal muscle stem cell	3.23e-10	57
cardiocyte	2.39e-09	16
endothelial cell of artery	1.69e-08	9
aortic smooth muscle cell	2.05e-08	10

Uber Anatomy

Ontology term	p-value	n
splanchnic layer of lateral plate mesoderm	4.67e-50	84
tube	1.47e-44	194
epithelial tube	3.85e-42	118
anatomical conduit	4.50e-41	241
vessel	9.02e-41	69
blood vessel	8.42e-40	60
epithelial tube open at both ends	8.42e-40	60
blood vasculature	8.42e-40	60
vascular cord	8.42e-40	60
anatomical cluster	1.51e-39	286
vasculature	7.85e-35	79
vascular system	7.85e-35	79
circulatory system	4.11e-33	113
artery	1.16e-31	42
arterial blood vessel	1.16e-31	42
arterial system	1.16e-31	42
cardiovascular system	1.44e-31	110
epithelium	5.67e-25	309
systemic artery	1.30e-24	33
systemic arterial system	1.30e-24	33
adult organism	1.53e-24	115
cell layer	1.81e-24	312
anatomical system	5.71e-17	625
multi-cellular organism	7.41e-17	659
anatomical group	8.69e-17	626
embryo	4.79e-16	612
unilaminar epithelium	6.01e-16	138
aorta	1.30e-15	21
aortic system	1.30e-15	21
compound organ	1.96e-15	69
primary circulatory organ	4.80e-15	27
endothelium	5.59e-15	18
blood vessel endothelium	5.59e-15	18
cardiovascular system endothelium	5.59e-15	18
multi-tissue structure	4.30e-14	347
embryonic structure	4.31e-14	605
developing anatomical structure	4.31e-14	605
germ layer	1.07e-13	604
embryonic tissue	1.07e-13	604
presumptive structure	1.07e-13	604
epiblast (generic)	1.07e-13	604
heart	1.34e-13	24
primitive heart tube	1.34e-13	24
primary heart field	1.34e-13	24
anterior lateral plate mesoderm	1.34e-13	24
heart tube	1.34e-13	24
heart primordium	1.34e-13	24
cardiac mesoderm	1.34e-13	24
cardiogenic plate	1.34e-13	24
heart rudiment	1.34e-13	24
simple squamous epithelium	7.22e-13	22
muscle tissue	2.39e-12	63
musculature	2.39e-12	63
musculature of body	2.39e-12	63
skeletal muscle tissue	8.01e-12	61
striated muscle tissue	8.01e-12	61
myotome	8.01e-12	61
mesoderm	9.32e-12	448
mesoderm-derived structure	9.32e-12	448
presumptive mesoderm	9.32e-12	448
lateral plate mesoderm	2.27e-11	216
squamous epithelium	6.86e-11	25
trunk mesenchyme	2.42e-10	143
dermomyotome	2.11e-09	70
mesenchyme	4.93e-09	238
entire embryonic mesenchyme	4.93e-09	238
neural tube	1.53e-08	57
neural rod	1.53e-08	57
future spinal cord	1.53e-08	57
neural keel	1.53e-08	57
endothelial tube	1.69e-08	9
arterial system endothelium	1.69e-08	9
endothelium of artery	1.69e-08	9
blood vessel smooth muscle	2.05e-08	10
arterial system smooth muscle	2.05e-08	10
artery smooth muscle tissue	2.05e-08	10
aorta smooth muscle tissue	2.05e-08	10
anterior neural tube	5.41e-08	42
reproductive organ	5.79e-08	48

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.