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|full_id=C3755_CD14CD16_acute_CD19_granulocyte_CD133_CD14_Whole
|full_id=C3755_CD14CD16_acute_CD19_granulocyte_CD133_CD14_Whole
|id=C3755
|id=C3755
|ontology_enrichment_celltype=CL:0000037!7.46e-47!172;CL:0000566!7.46e-47!172;CL:0000988!1.67e-45!182;CL:0002032!2.41e-45!165;CL:0000837!2.41e-45!165;CL:0000763!2.39e-41!112;CL:0000049!2.39e-41!112;CL:0000738!1.04e-31!140;CL:0000766!6.27e-30!76;CL:0002087!4.73e-28!119;CL:0002031!5.79e-28!124;CL:0000839!6.15e-27!70;CL:0000557!7.58e-25!71;CL:0002194!7.79e-24!63;CL:0000576!7.79e-24!63;CL:0000040!7.79e-24!63;CL:0000559!7.79e-24!63;CL:0002057!4.68e-22!42;CL:0002009!6.25e-22!65;CL:0000860!1.26e-18!45;CL:0000115!1.95e-11!35;CL:0000945!7.34e-11!24;CL:0000826!7.34e-11!24;CL:0000236!6.28e-09!14;CL:0002139!3.08e-08!24;CL:0002078!2.02e-07!44;CL:0000071!5.02e-07!18;CL:0002546!5.02e-07!18
|ontology_enrichment_disease=DOID:8692!2.72e-14!31;DOID:1240!2.92e-12!39;DOID:2531!1.85e-10!51;DOID:0060083!1.85e-10!51
|ontology_enrichment_uberon=UBERON:0002193!1.96e-30!112;UBERON:0002390!1.05e-28!102;UBERON:0003061!1.05e-28!102;UBERON:0002371!2.95e-21!80;UBERON:0002405!4.57e-21!115;UBERON:0007023!7.87e-21!115;UBERON:0003081!1.04e-20!216;UBERON:0001474!2.38e-17!86;UBERON:0004765!9.79e-13!101;UBERON:0001434!9.79e-13!101;UBERON:0000178!5.36e-09!15;UBERON:0000179!5.36e-09!15;UBERON:0000463!5.36e-09!15;UBERON:0001986!5.02e-07!18;UBERON:0004638!5.02e-07!18;UBERON:0004852!5.02e-07!18
}}
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Revision as of 14:40, 21 May 2012


Full id: C3755_CD14CD16_acute_CD19_granulocyte_CD133_CD14_Whole



Phase1 CAGE Peaks

Hg19::chr19:13213662..13213686,-p1@LYL1
Hg19::chr19:13213691..13213696,-p9@LYL1
Hg19::chr19:13213954..13214021,-p4@LYL1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell7.46e-47172
angioblastic mesenchymal cell7.46e-47172
hematopoietic cell1.67e-45182
hematopoietic oligopotent progenitor cell2.41e-45165
hematopoietic multipotent progenitor cell2.41e-45165
myeloid cell2.39e-41112
common myeloid progenitor2.39e-41112
leukocyte1.04e-31140
myeloid leukocyte6.27e-3076
nongranular leukocyte4.73e-28119
hematopoietic lineage restricted progenitor cell5.79e-28124
myeloid lineage restricted progenitor cell6.15e-2770
granulocyte monocyte progenitor cell7.58e-2571
monopoietic cell7.79e-2463
monocyte7.79e-2463
monoblast7.79e-2463
promonocyte7.79e-2463
CD14-positive, CD16-negative classical monocyte4.68e-2242
macrophage dendritic cell progenitor6.25e-2265
classical monocyte1.26e-1845
endothelial cell1.95e-1135
lymphocyte of B lineage7.34e-1124
pro-B cell7.34e-1124
B cell6.28e-0914
endothelial cell of vascular tree3.08e-0824
meso-epithelial cell2.02e-0744
blood vessel endothelial cell5.02e-0718
embryonic blood vessel endothelial progenitor cell5.02e-0718
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.96e-30112
hematopoietic system1.05e-28102
blood island1.05e-28102
bone marrow2.95e-2180
immune system4.57e-21115
adult organism7.87e-21115
lateral plate mesoderm1.04e-20216
bone element2.38e-1786
skeletal element9.79e-13101
skeletal system9.79e-13101
blood5.36e-0915
haemolymphatic fluid5.36e-0915
organism substance5.36e-0915
endothelium5.02e-0718
blood vessel endothelium5.02e-0718
cardiovascular system endothelium5.02e-0718
Disease
Ontology termp-valuen
myeloid leukemia2.72e-1431
leukemia2.92e-1239
hematologic cancer1.85e-1051
immune system cancer1.85e-1051


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.