MCL coexpression mm9:92
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005126 | hematopoietin/interferon-class (D200-domain) cytokine receptor binding | 1.86034201046507e-05 |
| GO:0005125 | cytokine activity | 1.86034201046507e-05 |
| GO:0008083 | growth factor activity | 0.00250463816784521 |
| GO:0005102 | receptor binding | 0.00326751961204418 |
| GO:0005615 | extracellular space | 0.025157508354791 |
| GO:0005308 | creatine transporter activity | 0.025157508354791 |
| GO:0005144 | interleukin-13 receptor binding | 0.025157508354791 |
| GO:0005140 | interleukin-9 receptor binding | 0.025157508354791 |
| GO:0005309 | creatine:sodium symporter activity | 0.025157508354791 |
| GO:0005142 | interleukin-11 receptor binding | 0.025157508354791 |
| GO:0042225 | interleukin-5 biosynthetic process | 0.025157508354791 |
| GO:0017047 | adrenocorticotropin-releasing hormone binding | 0.025157508354791 |
| GO:0045405 | regulation of interleukin-5 biosynthetic process | 0.025157508354791 |
| GO:0015881 | creatine transport | 0.025157508354791 |
| GO:0045407 | positive regulation of interleukin-5 biosynthetic process | 0.025157508354791 |
| GO:0044421 | extracellular region part | 0.0305231013189292 |
| GO:0005137 | interleukin-5 receptor binding | 0.0377155873938278 |
| GO:0017046 | peptide hormone binding | 0.0377155873938278 |
| GO:0032634 | interleukin-5 production | 0.0377155873938278 |
| GO:0004692 | cGMP-dependent protein kinase activity | 0.0377155873938278 |
| GO:0051247 | positive regulation of protein metabolic process | 0.04664591983252 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| insulating cell | 1.87e-86 | 2 |
| myelin accumulating cell | 1.87e-86 | 2 |
| Schwann cell | 1.87e-86 | 2 |
| non-myelinating Schwann cell | 1.87e-86 | 2 |
| myelinating Schwann cell;;Schwann cell | 1.87e-86 | 2 |
| terminal Schwann cell | 1.87e-86 | 2 |
| immature Schwann cell | 1.87e-86 | 2 |
| Schwann cell precursor | 1.87e-86 | 2 |
| barrier cell | 3.28e-58 | 3 |
| supportive cell | 3.28e-58 | 3 |
| stuff accumulating cell | 6.66e-30 | 6 |
| migratory neural crest cell | 1.57e-18 | 10 |
| neuron associated cell | 1.57e-18 | 10 |
| glial cell (sensu Vertebrata) | 1.57e-18 | 10 |
| neuron associated cell (sensu Vertebrata) | 1.57e-18 | 10 |
| glial cell | 1.57e-18 | 10 |
| glioblast | 1.57e-18 | 10 |
| glioblast (sensu Vertebrata) | 1.57e-18 | 10 |
| Ontology term | p-value | n |
|---|---|---|
| peripheral nervous system | 5.67e-17 | 11 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 2.31341e-07 |
| MA0004.1 | 0.995084 |
| MA0006.1 | 0.0432748 |
| MA0007.1 | 1.99514 |
| MA0009.1 | 0.345557 |
| MA0014.1 | 9.61274e-07 |
| MA0017.1 | 0.800397 |
| MA0019.1 | 0.124035 |
| MA0024.1 | 0.117409 |
| MA0025.1 | 0.122152 |
| MA0027.1 | 1.29451 |
| MA0028.1 | 0.00205434 |
| MA0029.1 | 0.103073 |
| MA0030.1 | 0.785402 |
| MA0031.1 | 0.0191726 |
| MA0038.1 | 0.366704 |
| MA0040.1 | 0.0410756 |
| MA0041.1 | 0.067275 |
| MA0042.1 | 0.0987079 |
| MA0043.1 | 0.235117 |
| MA0046.1 | 0.0473472 |
| MA0048.1 | 0.139001 |
| MA0050.1 | 1.26205 |
| MA0051.1 | 0.234146 |
| MA0052.1 | 0.672628 |
| MA0055.1 | 0.0170448 |
| MA0056.1 | 0 |
| MA0057.1 | 0.012643 |
| MA0058.1 | 0.9733 |
| MA0059.1 | 0.67611 |
| MA0060.1 | 6.70952e-05 |
| MA0061.1 | 0.112021 |
| MA0063.1 | 0 |
| MA0066.1 | 0.743227 |
| MA0067.1 | 1.6167 |
| MA0068.1 | 0.242675 |
| MA0069.1 | 0.0432623 |
| MA0070.1 | 0.15841 |
| MA0071.1 | 0.758935 |
| MA0072.1 | 0.151652 |
| MA0073.1 | 0.510101 |
| MA0074.1 | 1.08618 |
| MA0076.1 | 0.00525377 |
| MA0077.1 | 0.317291 |
| MA0078.1 | 1.29588 |
| MA0081.1 | 0.145132 |
| MA0083.1 | 0.234336 |
| MA0084.1 | 0.406076 |
| MA0087.1 | 0.193825 |
| MA0088.1 | 0.183113 |
| MA0089.1 | 0 |
| MA0090.1 | 1.50114 |
| MA0091.1 | 0.637863 |
| MA0092.1 | 0.435077 |
| MA0093.1 | 0.917304 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.376763 |
| MA0101.1 | 0.291133 |
| MA0103.1 | 0.0490063 |
| MA0105.1 | 0.000147828 |
| MA0106.1 | 0.310855 |
| MA0107.1 | 0.388996 |
| MA0108.2 | 0.503092 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0778898 |
| MA0113.1 | 2.28457 |
| MA0114.1 | 0.158017 |
| MA0115.1 | 0.237881 |
| MA0116.1 | 0.259735 |
| MA0117.1 | 0.0566054 |
| MA0119.1 | 0.195641 |
| MA0122.1 | 0.225733 |
| MA0124.1 | 0.90045 |
| MA0125.1 | 0.367299 |
| MA0130.1 | 0 |
| MA0131.1 | 0.675108 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.0793246 |
| MA0136.1 | 0.176183 |
| MA0139.1 | 0.00138777 |
| MA0140.1 | 0.132818 |
| MA0141.1 | 1.77285 |
| MA0142.1 | 0.386439 |
| MA0143.1 | 0.691973 |
| MA0144.1 | 0.0733311 |
| MA0145.1 | 0.0665063 |
| MA0146.1 | 2.77407e-06 |
| MA0147.1 | 0.381542 |
| MA0148.1 | 0.0266286 |
| MA0149.1 | 0.129919 |
| MA0062.2 | 0.000536847 |
| MA0035.2 | 0.571767 |
| MA0039.2 | 3.97676e-06 |
| MA0138.2 | 0.113221 |
| MA0002.2 | 0.26729 |
| MA0137.2 | 0.0161959 |
| MA0104.2 | 0.0967728 |
| MA0047.2 | 0.0142084 |
| MA0112.2 | 0.0476025 |
| MA0065.2 | 0.0485001 |
| MA0150.1 | 7.32232 |
| MA0151.1 | 0 |
| MA0152.1 | 0.787422 |
| MA0153.1 | 0.085752 |
| MA0154.1 | 0.046945 |
| MA0155.1 | 0.315601 |
| MA0156.1 | 0.0974784 |
| MA0157.1 | 0.326752 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0726718 |
| MA0160.1 | 4.01031 |
| MA0161.1 | 0 |
| MA0162.1 | 0.00500536 |
| MA0163.1 | 0.00811688 |
| MA0164.1 | 0.303668 |
| MA0080.2 | 1.24671 |
| MA0018.2 | 0.0400031 |
| MA0099.2 | 13.9734 |
| MA0079.2 | 0.000291524 |
| MA0102.2 | 1.13725 |
| MA0258.1 | 0.665669 |
| MA0259.1 | 0.0758627 |
| MA0442.1 | 0 |
