MCL coexpression mm9:90
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0019932 | second-messenger-mediated signaling | 1.67987448129523e-06 |
GO:0030695 | GTPase regulator activity | 3.73479831947888e-06 |
GO:0007212 | dopamine receptor signaling pathway | 4.53203076081549e-05 |
GO:0007154 | cell communication | 9.91948112958375e-05 |
GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | 9.91948112958375e-05 |
GO:0019933 | cAMP-mediated signaling | 9.91948112958375e-05 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 0.000108706869078756 |
GO:0007200 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.000148332225505885 |
GO:0007165 | signal transduction | 0.000285247603552889 |
GO:0048015 | phosphoinositide-mediated signaling | 0.000570405013893217 |
GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | 0.000861503214965366 |
GO:0007242 | intracellular signaling cascade | 0.000861503214965366 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 0.000861503214965366 |
GO:0021826 | substrate-independent telencephalic tangential migration | 0.000861503214965366 |
GO:0021853 | cerebral cortex GABAergic interneuron migration | 0.000861503214965366 |
GO:0021892 | cerebral cortex GABAergic interneuron differentiation | 0.000861503214965366 |
GO:0021843 | substrate-independent telencephalic tangential interneuron migration | 0.000861503214965366 |
GO:0021894 | cerebral cortex GABAergic interneuron development | 0.000861503214965366 |
GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | 0.000861503214965366 |
GO:0021830 | interneuron migration from the subpallium to the cortex | 0.000861503214965366 |
GO:0007626 | locomotory behavior | 0.000861503214965366 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.000861503214965366 |
GO:0007610 | behavior | 0.000984225140601695 |
GO:0007632 | visual behavior | 0.000990098977124497 |
GO:0008542 | visual learning | 0.000990098977124497 |
GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | 0.00123283964400915 |
GO:0014821 | phasic smooth muscle contraction | 0.00123283964400915 |
GO:0030432 | peristalsis | 0.00123283964400915 |
GO:0060158 | dopamine receptor, phospholipase C activating pathway | 0.00123283964400915 |
GO:0004112 | cyclic-nucleotide phosphodiesterase activity | 0.00138160435598277 |
GO:0008599 | protein phosphatase type 1 regulator activity | 0.00174930254044207 |
GO:0060134 | prepulse inhibition | 0.00174930254044207 |
GO:0035240 | dopamine binding | 0.00174930254044207 |
GO:0004952 | dopamine receptor activity | 0.00174930254044207 |
GO:0019888 | protein phosphatase regulator activity | 0.00223150747272338 |
GO:0005834 | heterotrimeric G-protein complex | 0.00228329043281991 |
GO:0022029 | telencephalon cell migration | 0.00228329043281991 |
GO:0021885 | forebrain cell migration | 0.00228329043281991 |
GO:0007625 | grooming behavior | 0.00228329043281991 |
GO:0019208 | phosphatase regulator activity | 0.00249826337560556 |
GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | 0.00249826337560556 |
GO:0007186 | G-protein coupled receptor protein signaling pathway | 0.00259331152330534 |
GO:0032102 | negative regulation of response to external stimulus | 0.00282808162663419 |
GO:0048585 | negative regulation of response to stimulus | 0.00282808162663419 |
GO:0001975 | response to amphetamine | 0.00433724391032152 |
GO:0021895 | cerebral cortex neuron differentiation | 0.00433724391032152 |
GO:0007617 | mating behavior | 0.00433724391032152 |
GO:0014075 | response to amine stimulus | 0.00433724391032152 |
GO:0032101 | regulation of response to external stimulus | 0.00433724391032152 |
GO:0050905 | neuromuscular process | 0.00489588316091451 |
GO:0007267 | cell-cell signaling | 0.00489588316091451 |
GO:0009966 | regulation of signal transduction | 0.00528640081502322 |
GO:0007612 | learning | 0.00528640081502322 |
GO:0019897 | extrinsic to plasma membrane | 0.0055083936311603 |
GO:0007190 | adenylate cyclase activation | 0.00656710072450938 |
GO:0004143 | diacylglycerol kinase activity | 0.00656710072450938 |
GO:0007193 | G-protein signaling, adenylate cyclase inhibiting pathway | 0.00656710072450938 |
GO:0001964 | startle response | 0.00656710072450938 |
GO:0007205 | protein kinase C activation | 0.00656710072450938 |
GO:0043085 | positive regulation of catalytic activity | 0.00714147858819942 |
GO:0051349 | positive regulation of lyase activity | 0.00714147858819942 |
GO:0045762 | positive regulation of adenylate cyclase activity | 0.00714147858819942 |
GO:0007618 | mating | 0.00714147858819942 |
GO:0031281 | positive regulation of cyclase activity | 0.00714147858819942 |
GO:0019098 | reproductive behavior | 0.00818829458176325 |
GO:0008081 | phosphoric diester hydrolase activity | 0.00974027484728955 |
GO:0005096 | GTPase activator activity | 0.0101340227563366 |
GO:0004864 | protein phosphatase inhibitor activity | 0.0101340227563366 |
GO:0045761 | regulation of adenylate cyclase activity | 0.0101340227563366 |
GO:0007611 | learning and/or memory | 0.0104724243175849 |
GO:0019898 | extrinsic to membrane | 0.0107721990982401 |
GO:0051339 | regulation of lyase activity | 0.012167552153248 |
GO:0031279 | regulation of cyclase activity | 0.012167552153248 |
GO:0009416 | response to light stimulus | 0.012169198284267 |
GO:0019212 | phosphatase inhibitor activity | 0.0132118061133011 |
GO:0042578 | phosphoric ester hydrolase activity | 0.013259024008737 |
GO:0051969 | regulation of transmission of nerve impulse | 0.0139106271670615 |
GO:0050804 | regulation of synaptic transmission | 0.0139106271670615 |
GO:0042417 | dopamine metabolic process | 0.0139106271670615 |
GO:0021954 | central nervous system neuron development | 0.0151545317852683 |
GO:0006936 | muscle contraction | 0.0158467089245332 |
GO:0003012 | muscle system process | 0.0158467089245332 |
GO:0007628 | adult walking behavior | 0.0158467089245332 |
GO:0051705 | behavioral interaction between organisms | 0.0158467089245332 |
GO:0021537 | telencephalon development | 0.0171199034859252 |
GO:0042165 | neurotransmitter binding | 0.0177117552055894 |
GO:0030594 | neurotransmitter receptor activity | 0.0177117552055894 |
GO:0021953 | central nervous system neuron differentiation | 0.017971629017873 |
GO:0015629 | actin cytoskeleton | 0.017971629017873 |
GO:0007268 | synaptic transmission | 0.017971629017873 |
GO:0009968 | negative regulation of signal transduction | 0.0180543782209528 |
GO:0033555 | multicellular organismal response to stress | 0.0186861691962858 |
GO:0009314 | response to radiation | 0.0193946091897893 |
GO:0006939 | smooth muscle contraction | 0.0194382049830469 |
GO:0031644 | regulation of neurological process | 0.0194382049830469 |
GO:0008047 | enzyme activator activity | 0.0194382049830469 |
GO:0048521 | negative regulation of behavior | 0.0194382049830469 |
GO:0051580 | regulation of neurotransmitter uptake | 0.0194382049830469 |
GO:0051586 | positive regulation of dopamine uptake | 0.0194382049830469 |
GO:0051940 | regulation of catecholamine uptake during transmission of nerve impulse | 0.0194382049830469 |
GO:0051588 | regulation of neurotransmitter transport | 0.0194382049830469 |
GO:0007621 | negative regulation of female receptivity | 0.0194382049830469 |
GO:0051590 | positive regulation of neurotransmitter transport | 0.0194382049830469 |
GO:0001670 | dopamine D2 receptor activity | 0.0194382049830469 |
GO:0051944 | positive regulation of catecholamine uptake during transmission of nerve impulse | 0.0194382049830469 |
GO:0051584 | regulation of dopamine uptake | 0.0194382049830469 |
GO:0001590 | dopamine D1 receptor activity | 0.0194382049830469 |
GO:0051582 | positive regulation of neurotransmitter uptake | 0.0194382049830469 |
GO:0030072 | peptide hormone secretion | 0.0197621429793617 |
GO:0007166 | cell surface receptor linked signal transduction | 0.019762629081123 |
GO:0006584 | catecholamine metabolic process | 0.0201087890220663 |
GO:0002790 | peptide secretion | 0.0201087890220663 |
GO:0018958 | phenol metabolic process | 0.0201087890220663 |
GO:0010033 | response to organic substance | 0.0201087890220663 |
GO:0005216 | ion channel activity | 0.0201087890220663 |
GO:0042493 | response to drug | 0.0211086688206527 |
GO:0032147 | activation of protein kinase activity | 0.0211086688206527 |
GO:0022838 | substrate specific channel activity | 0.022138635278208 |
GO:0006811 | ion transport | 0.0223440219917123 |
GO:0005516 | calmodulin binding | 0.0223440219917123 |
GO:0019226 | transmission of nerve impulse | 0.0245225117029149 |
GO:0007631 | feeding behavior | 0.0259143200223233 |
GO:0022803 | passive transmembrane transporter activity | 0.0259775108574798 |
GO:0015267 | channel activity | 0.0259775108574798 |
GO:0043005 | neuron projection | 0.026894284982276 |
GO:0042133 | neurotransmitter metabolic process | 0.0295258541562641 |
GO:0015833 | peptide transport | 0.0295258541562641 |
GO:0048755 | branching morphogenesis of a nerve | 0.0295258541562641 |
GO:0060181 | female receptivity | 0.0295258541562641 |
GO:0051967 | negative regulation of synaptic transmission, glutamatergic | 0.0295258541562641 |
GO:0045924 | regulation of female receptivity | 0.0295258541562641 |
GO:0060180 | female mating behavior | 0.0295258541562641 |
GO:0050805 | negative regulation of synaptic transmission | 0.0295258541562641 |
GO:0050795 | regulation of behavior | 0.0295258541562641 |
GO:0030314 | junctional membrane complex | 0.0295258541562641 |
GO:0030147 | natriuresis | 0.0295258541562641 |
GO:0007168 | receptor guanylyl cyclase signaling pathway | 0.0295258541562641 |
GO:0032922 | circadian regulation of gene expression | 0.0295258541562641 |
GO:0001973 | adenosine receptor signaling pathway | 0.0295258541562641 |
GO:0051970 | negative regulation of transmission of nerve impulse | 0.0295258541562641 |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 0.0295258541562641 |
GO:0001588 | dopamine D1 receptor-like receptor activity | 0.0295258541562641 |
GO:0046879 | hormone secretion | 0.0318995508358186 |
GO:0008344 | adult locomotory behavior | 0.0332004339441862 |
GO:0008227 | amine receptor activity | 0.0345159122737346 |
GO:0048583 | regulation of response to stimulus | 0.0358454929048809 |
GO:0050790 | regulation of catalytic activity | 0.0367663802864149 |
GO:0019992 | diacylglycerol binding | 0.0369374221561485 |
GO:0030425 | dendrite | 0.039250326057089 |
GO:0051583 | dopamine uptake | 0.039250326057089 |
GO:0007217 | tachykinin signaling pathway | 0.039250326057089 |
GO:0001591 | dopamine D2 receptor-like receptor activity | 0.039250326057089 |
GO:0060160 | negative regulation of dopamine receptor signaling pathway | 0.039250326057089 |
GO:0048149 | behavioral response to ethanol | 0.039250326057089 |
GO:0051934 | catecholamine uptake during transmission of nerve impulse | 0.039250326057089 |
GO:0043278 | response to morphine | 0.039250326057089 |
GO:0060124 | positive regulation of growth hormone secretion | 0.039250326057089 |
GO:0014072 | response to isoquinoline alkaloid | 0.039250326057089 |
GO:0060159 | regulation of dopamine receptor signaling pathway | 0.039250326057089 |
GO:0051937 | catecholamine transport | 0.039250326057089 |
GO:0005083 | small GTPase regulator activity | 0.0431594941669944 |
GO:0030334 | regulation of cell migration | 0.0446173629943963 |
GO:0002028 | regulation of sodium ion transport | 0.0491852084840403 |
GO:0060123 | regulation of growth hormone secretion | 0.0491852084840403 |
GO:0032228 | regulation of synaptic transmission, GABAergic | 0.0491852084840403 |
GO:0051898 | negative regulation of protein kinase B signaling cascade | 0.0491852084840403 |
GO:0003091 | renal water homeostasis | 0.0491852084840403 |
GO:0004865 | type 1 serine/threonine specific protein phosphatase inhibitor activity | 0.0491852084840403 |
GO:0051932 | synaptic transmission, GABAergic | 0.0491852084840403 |
GO:0030146 | diuresis | 0.0491852084840403 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
CNS neuron (sensu Vertebrata) | 7.71e-10 | 23 |
neuroblast (sensu Vertebrata) | 7.71e-10 | 23 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.306284 |
MA0004.1 | 0.5335 |
MA0006.1 | 2.79502 |
MA0007.1 | 0.640051 |
MA0009.1 | 1.34029 |
MA0014.1 | 0.163575 |
MA0017.1 | 0.0162901 |
MA0019.1 | 0.42017 |
MA0024.1 | 0.0259562 |
MA0025.1 | 0.116516 |
MA0027.1 | 1.28234 |
MA0028.1 | 0.00157501 |
MA0029.1 | 0.0220379 |
MA0030.1 | 0.464495 |
MA0031.1 | 0.0174577 |
MA0038.1 | 0.340572 |
MA0040.1 | 0.150195 |
MA0041.1 | 0.0580034 |
MA0042.1 | 0.0857651 |
MA0043.1 | 0.485632 |
MA0046.1 | 0.0441506 |
MA0048.1 | 1.02665 |
MA0050.1 | 0.360288 |
MA0051.1 | 0.215822 |
MA0052.1 | 0.359282 |
MA0055.1 | 5.3237 |
MA0056.1 | 0 |
MA0057.1 | 1.21996 |
MA0058.1 | 0.413224 |
MA0059.1 | 0.0512708 |
MA0060.1 | 0.0277139 |
MA0061.1 | 0.365943 |
MA0063.1 | 0 |
MA0066.1 | 0.0109432 |
MA0067.1 | 0.516325 |
MA0068.1 | 1.30818 |
MA0069.1 | 0.359807 |
MA0070.1 | 0.0378478 |
MA0071.1 | 0.0313058 |
MA0072.1 | 0.142655 |
MA0073.1 | 11.5245 |
MA0074.1 | 0.379684 |
MA0076.1 | 0.000300643 |
MA0077.1 | 0.300586 |
MA0078.1 | 0.147307 |
MA0081.1 | 0.582158 |
MA0083.1 | 0.222884 |
MA0084.1 | 0.396473 |
MA0087.1 | 0.048812 |
MA0088.1 | 0.112609 |
MA0089.1 | 0 |
MA0090.1 | 0.723784 |
MA0091.1 | 0.18125 |
MA0092.1 | 0.397494 |
MA0093.1 | 0.53023 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0214886 |
MA0101.1 | 0.00437004 |
MA0103.1 | 0.375577 |
MA0105.1 | 0.485928 |
MA0106.1 | 0.289216 |
MA0107.1 | 0.0180766 |
MA0108.2 | 0.0487395 |
MA0109.1 | 0 |
MA0111.1 | 1.02528 |
MA0113.1 | 0.393789 |
MA0114.1 | 0.0335033 |
MA0115.1 | 0.0631938 |
MA0116.1 | 1.23711 |
MA0117.1 | 0.434776 |
MA0119.1 | 0.514047 |
MA0122.1 | 0.468767 |
MA0124.1 | 0.14492 |
MA0125.1 | 0.716187 |
MA0130.1 | 0 |
MA0131.1 | 0.2332 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.936996 |
MA0136.1 | 0.00128696 |
MA0139.1 | 0.215765 |
MA0140.1 | 0.120006 |
MA0141.1 | 0.243348 |
MA0142.1 | 1.66675 |
MA0143.1 | 0.0623205 |
MA0144.1 | 0.0608731 |
MA0145.1 | 1.47312 |
MA0146.1 | 0.0671858 |
MA0147.1 | 0.441042 |
MA0148.1 | 0.0542661 |
MA0149.1 | 0.538272 |
MA0062.2 | 1.0594e-07 |
MA0035.2 | 0.0228041 |
MA0039.2 | 0.325871 |
MA0138.2 | 0.221451 |
MA0002.2 | 0.0547463 |
MA0137.2 | 0.0132878 |
MA0104.2 | 0.389026 |
MA0047.2 | 0.102479 |
MA0112.2 | 0.527284 |
MA0065.2 | 0.451426 |
MA0150.1 | 0.217693 |
MA0151.1 | 0 |
MA0152.1 | 0.0424606 |
MA0153.1 | 1.46538 |
MA0154.1 | 0.443864 |
MA0155.1 | 2.08403 |
MA0156.1 | 4.58088e-05 |
MA0157.1 | 0.0115551 |
MA0158.1 | 0 |
MA0159.1 | 0.0187967 |
MA0160.1 | 0.111241 |
MA0161.1 | 0 |
MA0162.1 | 5.64303 |
MA0163.1 | 0.99603 |
MA0164.1 | 0.0800198 |
MA0080.2 | 0.0029302 |
MA0018.2 | 0.0880384 |
MA0099.2 | 0.212354 |
MA0079.2 | 7.02072 |
MA0102.2 | 1.11584 |
MA0258.1 | 0.040707 |
MA0259.1 | 0.286377 |
MA0442.1 | 0 |