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MCL coexpression mm9:668

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Phase1 CAGE Peaks

 Short description
Mm9::chr13:31898767..31898785,+p4@Foxc1
Mm9::chr13:99124189..99124205,+p1@Foxd1
Mm9::chr13:99124236..99124243,+p2@Foxd1
Mm9::chr13:99124729..99124745,+p@chr13:99124729..99124745
+
Mm9::chr2:165420509..165420580,+p1@Eya2
Mm9::chr5:137463527..137463538,+p9@Plod3
Mm9::chr5:38215819..38215823,-p1@Msx1
Mm9::chr6:72185396..72185413,-p6@Atoh8
Mm9::chr8:123640063..123640077,+p1@Foxc2
Mm9::chr8:123640090..123640101,+p2@Foxc2
Mm9::chr9:98325725..98325749,+p@chr9:98325725..98325749
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003007heart morphogenesis5.83960470390845e-05
GO:0008301DNA bending activity7.15673488729175e-05
GO:0048844artery morphogenesis7.15673488729175e-05
GO:0055010ventricular cardiac muscle morphogenesis7.15673488729175e-05
GO:0001945lymph vessel development7.15673488729175e-05
GO:0048341paraxial mesoderm formation7.5383323061609e-05
GO:0055008cardiac muscle morphogensis7.5383323061609e-05
GO:0001822kidney development7.5383323061609e-05
GO:0046620regulation of organ growth7.66010241537851e-05
GO:0001655urogenital system development7.66010241537851e-05
GO:0060038cardiac muscle cell proliferation7.70303049760186e-05
GO:0048644muscle morphogenesis7.70303049760186e-05
GO:0014855striated muscle cell proliferation7.70303049760186e-05
GO:0048340paraxial mesoderm morphogenesis9.19479537249385e-05
GO:0006357regulation of transcription from RNA polymerase II promoter0.000116604844891553
GO:0035265organ growth0.000133418602801376
GO:0006366transcription from RNA polymerase II promoter0.000133418602801376
GO:0048339paraxial mesoderm development0.000133418602801376
GO:0035050embryonic heart tube development0.000133418602801376
GO:0033002muscle cell proliferation0.000133418602801376
GO:0043565sequence-specific DNA binding0.000133418602801376
GO:0048010vascular endothelial growth factor receptor signaling pathway0.000147771138511505
GO:0030199collagen fibril organization0.000156267844528636
GO:0001974blood vessel remodeling0.000156267844528636
GO:0048468cell development0.000175048166605948
GO:0043066negative regulation of apoptosis0.000198974838792371
GO:0043069negative regulation of programmed cell death0.00019941297764676
GO:0003705RNA polymerase II transcription factor activity, enhancer binding0.000217977795038277
GO:0007517muscle development0.000246504110865134
GO:0007507heart development0.000255872021783747
GO:0001707mesoderm formation0.000336138365925494
GO:0006915apoptosis0.000336138365925494
GO:0012501programmed cell death0.000340740012340497
GO:0048332mesoderm morphogenesis0.000340740012340497
GO:0001704formation of primary germ layer0.000357419631033899
GO:0008219cell death0.000365174092335362
GO:0016265death0.000365174092335362
GO:0043009chordate embryonic development0.000420508607951796
GO:0009792embryonic development ending in birth or egg hatching0.000420508607951796
GO:0001657ureteric bud development0.000420508607951796
GO:0014032neural crest cell development0.000420508607951796
GO:0014033neural crest cell differentiation0.000420508607951796
GO:0035150regulation of tube size0.000443745652675687
GO:0050880regulation of blood vessel size0.000443745652675687
GO:0003018vascular process in circulatory system0.000443745652675687
GO:0014031mesenchymal cell development0.000560669895248023
GO:0048762mesenchymal cell differentiation0.000560669895248023
GO:0007167enzyme linked receptor protein signaling pathway0.000606857514252424
GO:0048869cellular developmental process0.000654571451121736
GO:0030154cell differentiation0.000654571451121736
GO:0003700transcription factor activity0.000654571451121736
GO:0001656metanephros development0.000676304752546427
GO:0007498mesoderm development0.000787634042924461
GO:0007219Notch signaling pathway0.000805111373058172
GO:0006355regulation of transcription, DNA-dependent0.000841397142485504
GO:0006351transcription, DNA-dependent0.00087015276353609
GO:0032774RNA biosynthetic process0.00087015276353609
GO:0003677DNA binding0.000908457371142443
GO:0030198extracellular matrix organization and biogenesis0.00094426955727915
GO:0045449regulation of transcription0.00094426955727915
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.00102050811980884
GO:0006350transcription0.00106294739370639
GO:0007369gastrulation0.00106294739370639
GO:0010468regulation of gene expression0.00121365013836572
GO:0042981regulation of apoptosis0.00121783817363992
GO:0043067regulation of programmed cell death0.00123766949604822
GO:0031323regulation of cellular metabolic process0.0014057899455575
GO:0048729tissue morphogenesis0.00142083030173103
GO:0043010camera-type eye development0.00142083030173103
GO:0003702RNA polymerase II transcription factor activity0.00143812190857447
GO:0007275multicellular organismal development0.00147269513102191
GO:0006916anti-apoptosis0.00147269513102191
GO:0032808lacrimal gland development0.00149196716771647
GO:0019222regulation of metabolic process0.00151457445837975
GO:0009653anatomical structure morphogenesis0.00154863928668225
GO:0016070RNA metabolic process0.00167038896588936
GO:0009790embryonic development0.00174998546026162
GO:0008283cell proliferation0.00190301382543278
GO:0001503ossification0.00190683017788915
GO:0031214biomineral formation0.0019166685748341
GO:0008015blood circulation0.0019166685748341
GO:0003013circulatory system process0.0019166685748341
GO:0043062extracellular structure organization and biogenesis0.00205577104252653
GO:0046849bone remodeling0.00217507082587939
GO:0009887organ morphogenesis0.00217507082587939
GO:0001654eye development0.00218859969867681
GO:0043283biopolymer metabolic process0.00221801486610398
GO:0048343paraxial mesodermal cell fate commitment0.00241990447998031
GO:0001946lymphangiogenesis0.00241990447998031
GO:0048342paraxial mesodermal cell differentiation0.00241990447998031
GO:0048513organ development0.00251199589922784
GO:0001701in utero embryonic development0.00267450316634048
GO:0048771tissue remodeling0.00273480680691769
GO:0010467gene expression0.00317181018120513
GO:0008475procollagen-lysine 5-dioxygenase activity0.00336735473890061
GO:0001710mesodermal cell fate commitment0.00336735473890061
GO:0048333mesodermal cell differentiation0.00336735473890061
GO:0003676nucleic acid binding0.00340510036640844
GO:0007399nervous system development0.00350202083618558
GO:0035239tube morphogenesis0.0037545139877692
GO:0040008regulation of growth0.0037545139877692
GO:0032502developmental process0.0037959290179612
GO:0048703embryonic viscerocranium morphogenesis0.00422756924733131
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.00441338829450723
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0045199112998873
GO:0048731system development0.00479757132385624
GO:0048514blood vessel morphogenesis0.0048250074971598
GO:0031490chromatin DNA binding0.00503898223525757
GO:0001501skeletal development0.00512211383636323
GO:0007420brain development0.00530039310425389
GO:0007423sensory organ development0.00531788971464045
GO:0048646anatomical structure formation0.00531788971464045
GO:0008354germ cell migration0.00572541466457373
GO:0048701embryonic cranial skeleton morphogenesis0.00572541466457373
GO:0050794regulation of cellular process0.00572541466457373
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.00574991485824074
GO:0048598embryonic morphogenesis0.00588061462113732
GO:0035295tube development0.00588061462113732
GO:0001568blood vessel development0.00594593140978722
GO:0001944vasculature development0.00606904610846606
GO:0048523negative regulation of cellular process0.00643221661462505
GO:0048856anatomical structure development0.00741495559696795
GO:0007417central nervous system development0.00741495559696795
GO:0043170macromolecule metabolic process0.00741495559696795
GO:0045893positive regulation of transcription, DNA-dependent0.00758778392991316
GO:0048519negative regulation of biological process0.00758778392991316
GO:0050789regulation of biological process0.00855235929487186
GO:0048704embryonic skeletal morphogenesis0.00927195405056161
GO:0030901midbrain development0.00927195405056161
GO:0016477cell migration0.00973041177184383
GO:0009888tissue development0.0101390133189321
GO:0045941positive regulation of transcription0.0101390133189321
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0104863220917352
GO:0035272exocrine system development0.0113547456293787
GO:0065007biological regulation0.0125701239648157
GO:0009725response to hormone stimulus0.0126885163954944
GO:0048706embryonic skeletal development0.0126885163954944
GO:0006928cell motility0.0127059919028333
GO:0051674localization of cell0.0127059919028333
GO:0005634nucleus0.0133156809330556
GO:0032501multicellular organismal process0.0135623576584384
GO:0001541ovarian follicle development0.0137674292428574
GO:0031325positive regulation of cellular metabolic process0.0140356843231172
GO:0044238primary metabolic process0.0140356843231172
GO:0006022aminoglycan metabolic process0.0140356843231172
GO:0030203glycosaminoglycan metabolic process0.0140356843231172
GO:0031418L-ascorbic acid binding0.0140356843231172
GO:0044237cellular metabolic process0.0142132735767427
GO:0043231intracellular membrane-bound organelle0.0145660465564809
GO:0043227membrane-bound organelle0.0145660465564809
GO:0009893positive regulation of metabolic process0.0149727271035296
GO:0001569patterning of blood vessels0.0157094986923561
GO:0048705skeletal morphogenesis0.0163135424484417
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.0174975588847288
GO:0008286insulin receptor signaling pathway0.0174975588847288
GO:0005667transcription factor complex0.0184482272073624
GO:0030509BMP signaling pathway0.0198986971425132
GO:0022601menstrual cycle phase0.0198986971425132
GO:0022602menstrual cycle process0.0204520341561944
GO:0008585female gonad development0.0236921077603396
GO:0046660female sex differentiation0.0240642194559199
GO:0046545development of primary female sexual characteristics0.0240642194559199
GO:0009880embryonic pattern specification0.0261971158750841
GO:0042698menstrual cycle0.0261971158750841
GO:0043229intracellular organelle0.0261971158750841
GO:0043226organelle0.0261971158750841
GO:0044451nucleoplasm part0.0264031601890037
GO:0005654nucleoplasm0.028695203783531
GO:0043566structure-specific DNA binding0.0306960714670178
GO:0008632apoptotic program0.0311461302958456
GO:0008406gonad development0.032217241520755
GO:0048608reproductive structure development0.0332750766735975
GO:0065008regulation of biological quality0.0343796788979883
GO:0045137development of primary sexual characteristics0.0357606165460643
GO:0048754branching morphogenesis of a tube0.0357606165460643
GO:0051213dioxygenase activity0.0359602319518678
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen0.0359602319518678
GO:0016701oxidoreductase activity, acting on single donors with incorporation of molecular oxygen0.036358308862171
GO:0031981nuclear lumen0.0373187989706492
GO:0001763morphogenesis of a branching structure0.0373187989706492
GO:0030326embryonic limb morphogenesis0.0373187989706492
GO:0035113embryonic appendage morphogenesis0.0373187989706492
GO:0048609reproductive process in a multicellular organism0.0415459412171078
GO:0032504multicellular organism reproduction0.0415459412171078
GO:0007548sex differentiation0.0424714038642085
GO:0048732gland development0.0428147060306397
GO:0048522positive regulation of cellular process0.0432596892398072
GO:0035107appendage morphogenesis0.0432596892398072
GO:0035108limb morphogenesis0.0432596892398072
GO:0007165signal transduction0.0433399854871231
GO:0043233organelle lumen0.0433399854871231
GO:0031974membrane-enclosed lumen0.0433399854871231
GO:0060173limb development0.0433399854871231
GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway0.0433399854871231
GO:0048736appendage development0.0433399854871231
GO:0007411axon guidance0.0433399854871231
GO:0004725protein tyrosine phosphatase activity0.0466500409963091
GO:0003006reproductive developmental process0.0466500409963091



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.11.57537
MA0004.10.879856
MA0006.10.186435
MA0007.10.316976
MA0009.10.743257
MA0014.10.919317
MA0017.10.207884
MA0019.10.567591
MA0024.10.70077
MA0025.10.971686
MA0027.12.37948
MA0028.10.567414
MA0029.10.679737
MA0030.10.686088
MA0031.10.651724
MA0038.10.462726
MA0040.10.755433
MA0041.10.263922
MA0042.10.252679
MA0043.10.837621
MA0046.10.778239
MA0048.11.17627
MA0050.10.365212
MA0051.10.471092
MA0052.10.76328
MA0055.11.79839
MA0056.10
MA0057.10.406124
MA0058.11.27846
MA0059.12.03293
MA0060.10.789184
MA0061.10.147394
MA0063.10
MA0066.10.452472
MA0067.11.08124
MA0068.10.187364
MA0069.10.76361
MA0070.12.97928
MA0071.10.364454
MA0072.10.745922
MA0073.10.0672071
MA0074.11.07546
MA0076.10.223625
MA0077.10.724865
MA0078.10.502121
MA0081.10.277253
MA0083.10.836845
MA0084.11.4063
MA0087.10.794721
MA0088.10.534411
MA0089.10
MA0090.10.299987
MA0091.10.342071
MA0092.10.812369
MA0093.10.58345
MA0095.10
MA0098.10
MA0100.10.408523
MA0101.10.265031
MA0103.10.216742
MA0105.10.0759118
MA0106.10.509454
MA0107.10.211681
MA0108.20.589413
MA0109.10
MA0111.10.839864
MA0113.10.482899
MA0114.10.145642
MA0115.10.84036
MA0116.10.186271
MA0117.10.808813
MA0119.10.733279
MA0122.10.828211
MA0124.11.02871
MA0125.10.955734
MA0130.10
MA0131.12.36861
MA0132.10
MA0133.10
MA0135.10.873285
MA0136.10.437601
MA0139.12.28235
MA0140.10.408417
MA0141.10.233109
MA0142.10.63775
MA0143.10.49828
MA0144.10.88666
MA0145.10.3137
MA0146.12.1827
MA0147.10.475899
MA0148.10.344843
MA0149.10.269772
MA0062.20.0791588
MA0035.20.412747
MA0039.20.35217
MA0138.20.555696
MA0002.20.105469
MA0137.20.652494
MA0104.20.369356
MA0047.20.46201
MA0112.20.133279
MA0065.20.133827
MA0150.10.316876
MA0151.10
MA0152.11.16826
MA0153.10.889592
MA0154.10.759699
MA0155.10.354827
MA0156.10.634231
MA0157.10.606944
MA0158.10
MA0159.10.495113
MA0160.10.918217
MA0161.10
MA0162.11.95903
MA0163.10.355774
MA0164.10.437937
MA0080.20.609443
MA0018.20.446948
MA0099.20.549696
MA0079.22.00278
MA0102.21.45844
MA0258.10.135621
MA0259.10.455671
MA0442.10
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