MCL coexpression mm9:3521
From FANTOM5_SSTAR
Phase1 CAGE Peaks
| Short description | |
|---|---|
| Mm9::chr5:64551446..64551459,+ | p6@LOC677502 p8@Tbc1d1 |
| Mm9::chr5:64551466..64551509,+ | p1@LOC677502 p2@Tbc1d1 |
| Mm9::chr5:64551510..64551535,+ | p3@LOC677502 p5@Tbc1d1 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0032313 | regulation of Rab GTPase activity | 0.012293869500904 |
| GO:0032482 | Rab protein signal transduction | 0.012293869500904 |
| GO:0032483 | regulation of Rab protein signal transduction | 0.012293869500904 |
| GO:0005097 | Rab GTPase activator activity | 0.012293869500904 |
| GO:0032318 | regulation of Ras GTPase activity | 0.012293869500904 |
| GO:0005099 | Ras GTPase activator activity | 0.0145912087510729 |
| GO:0043087 | regulation of GTPase activity | 0.0170304685726808 |
| GO:0046578 | regulation of Ras protein signal transduction | 0.0216360640400524 |
| GO:0051336 | regulation of hydrolase activity | 0.0216360640400524 |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0216360640400524 |
| GO:0007265 | Ras protein signal transduction | 0.0216360640400524 |
| GO:0005083 | small GTPase regulator activity | 0.0216360640400524 |
| GO:0005096 | GTPase activator activity | 0.0216360640400524 |
| GO:0008047 | enzyme activator activity | 0.0268762082162619 |
| GO:0050790 | regulation of catalytic activity | 0.0330385488182188 |
| GO:0030695 | GTPase regulator activity | 0.0330385488182188 |
| GO:0065009 | regulation of a molecular function | 0.0330385488182188 |
| GO:0009966 | regulation of signal transduction | 0.0330385488182188 |
| GO:0007264 | small GTPase mediated signal transduction | 0.0330385488182188 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lymphocyte | 2.45e-07 | 13 |
| common lymphoid progenitor | 2.45e-07 | 13 |
| hematopoietic lineage restricted progenitor cell | 4.67e-07 | 25 |
| nucleate cell | 5.11e-07 | 16 |
| lymphoid lineage restricted progenitor cell | 5.40e-07 | 12 |
| Ontology term | p-value | n |
|---|---|---|
| endoderm-derived structure | 9.35e-13 | 118 |
| endoderm | 9.35e-13 | 118 |
| presumptive endoderm | 9.35e-13 | 118 |
| digestive system | 1.23e-12 | 116 |
| digestive tract | 1.23e-12 | 116 |
| primitive gut | 1.23e-12 | 116 |
| subdivision of digestive tract | 4.22e-12 | 114 |
| respiratory system | 1.48e-08 | 42 |
| respiratory tract | 4.60e-08 | 41 |
| gastrointestinal system | 3.15e-07 | 47 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 1.35193 |
| MA0004.1 | 0.801718 |
| MA0006.1 | 0.60285 |
| MA0007.1 | 0.784593 |
| MA0009.1 | 1.27673 |
| MA0014.1 | 2.60474 |
| MA0017.1 | 0.635031 |
| MA0019.1 | 1.08369 |
| MA0024.1 | 1.23079 |
| MA0025.1 | 1.51835 |
| MA0027.1 | 2.9431 |
| MA0028.1 | 0.61552 |
| MA0029.1 | 1.20789 |
| MA0030.1 | 1.21482 |
| MA0031.1 | 1.17722 |
| MA0038.1 | 0.963265 |
| MA0040.1 | 1.28983 |
| MA0041.1 | 0.714279 |
| MA0042.1 | 0.69885 |
| MA0043.1 | 1.3775 |
| MA0046.1 | 1.31428 |
| MA0048.1 | 4.47146 |
| MA0050.1 | 0.845669 |
| MA0051.1 | 0.973068 |
| MA0052.1 | 1.29825 |
| MA0055.1 | 11.1471 |
| MA0056.1 | 0 |
| MA0057.1 | 4.34959 |
| MA0058.1 | 0.690848 |
| MA0059.1 | 0.705317 |
| MA0060.1 | 0.502699 |
| MA0061.1 | 1.33581 |
| MA0063.1 | 0 |
| MA0066.1 | 0.951196 |
| MA0067.1 | 1.63197 |
| MA0068.1 | 2.46203 |
| MA0069.1 | 1.29861 |
| MA0070.1 | 1.28847 |
| MA0071.1 | 0.844726 |
| MA0072.1 | 1.2796 |
| MA0073.1 | 0.0430758 |
| MA0074.1 | 0.911576 |
| MA0076.1 | 0.657929 |
| MA0077.1 | 1.2569 |
| MA0078.1 | 1.0091 |
| MA0081.1 | 0.732313 |
| MA0083.1 | 1.37668 |
| MA0084.1 | 1.96428 |
| MA0087.1 | 1.33189 |
| MA0088.1 | 0.766354 |
| MA0089.1 | 0 |
| MA0090.1 | 0.762482 |
| MA0091.1 | 1.91105 |
| MA0092.1 | 0.762845 |
| MA0093.1 | 0.62555 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.89873 |
| MA0101.1 | 1.70277 |
| MA0103.1 | 0.647985 |
| MA0105.1 | 0.405648 |
| MA0106.1 | 1.01755 |
| MA0107.1 | 3.81175 |
| MA0108.2 | 1.10817 |
| MA0109.1 | 0 |
| MA0111.1 | 0.778753 |
| MA0113.1 | 0.986839 |
| MA0114.1 | 0.537669 |
| MA0115.1 | 1.38041 |
| MA0116.1 | 2.49617 |
| MA0117.1 | 1.34691 |
| MA0119.1 | 0.716476 |
| MA0122.1 | 1.36752 |
| MA0124.1 | 1.57762 |
| MA0125.1 | 1.5017 |
| MA0130.1 | 0 |
| MA0131.1 | 1.07881 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.4152 |
| MA0136.1 | 0.933582 |
| MA0139.1 | 1.16863 |
| MA0140.1 | 0.898603 |
| MA0141.1 | 0.671467 |
| MA0142.1 | 1.16183 |
| MA0143.1 | 1.00467 |
| MA0144.1 | 0.541532 |
| MA0145.1 | 0.292366 |
| MA0146.1 | 0.900029 |
| MA0147.1 | 0.556853 |
| MA0148.1 | 0.820161 |
| MA0149.1 | 0.722227 |
| MA0062.2 | 0.412742 |
| MA0035.2 | 0.903829 |
| MA0039.2 | 0.40695 |
| MA0138.2 | 1.07027 |
| MA0002.2 | 0.466067 |
| MA0137.2 | 0.668025 |
| MA0104.2 | 0.48458 |
| MA0047.2 | 0.962424 |
| MA0112.2 | 0.794478 |
| MA0065.2 | 0.292912 |
| MA0150.1 | 0.784464 |
| MA0151.1 | 0 |
| MA0152.1 | 0.962542 |
| MA0153.1 | 1.43238 |
| MA0154.1 | 0.925147 |
| MA0155.1 | 0.312898 |
| MA0156.1 | 0.656895 |
| MA0157.1 | 1.12772 |
| MA0158.1 | 0 |
| MA0159.1 | 0.569393 |
| MA0160.1 | 0.823568 |
| MA0161.1 | 0 |
| MA0162.1 | 0.964824 |
| MA0163.1 | 0.157796 |
| MA0164.1 | 0.933981 |
| MA0080.2 | 0.64167 |
| MA0018.2 | 0.944669 |
| MA0099.2 | 1.06348 |
| MA0079.2 | 6.11462 |
| MA0102.2 | 2.01714 |
| MA0258.1 | 0.520639 |
| MA0259.1 | 0.543506 |
| MA0442.1 | 0 |
