MCL coexpression mm9:321
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0043283 | biopolymer metabolic process | 0.00794587097948635 |
| GO:0003677 | DNA binding | 0.00794587097948635 |
| GO:0043170 | macromolecule metabolic process | 0.0113426159567994 |
| GO:0005634 | nucleus | 0.0113426159567994 |
| GO:0003676 | nucleic acid binding | 0.0113426159567994 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.0116253998330533 |
| GO:0006351 | transcription, DNA-dependent | 0.0116253998330533 |
| GO:0032774 | RNA biosynthetic process | 0.0116253998330533 |
| GO:0008270 | zinc ion binding | 0.0116253998330533 |
| GO:0045449 | regulation of transcription | 0.0121275033569461 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0125967280283161 |
| GO:0006350 | transcription | 0.0126131748376515 |
| GO:0010468 | regulation of gene expression | 0.0145568400482656 |
| GO:0031323 | regulation of cellular metabolic process | 0.0176996880778582 |
| GO:0006512 | ubiquitin cycle | 0.0189891975018616 |
| GO:0019222 | regulation of metabolic process | 0.0196114607507608 |
| GO:0044238 | primary metabolic process | 0.0196114607507608 |
| GO:0044237 | cellular metabolic process | 0.0196114607507608 |
| GO:0016070 | RNA metabolic process | 0.0197265385463275 |
| GO:0046914 | transition metal ion binding | 0.0222689625102905 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0234264727644384 |
| GO:0051100 | negative regulation of binding | 0.0234264727644384 |
| GO:0043392 | negative regulation of DNA binding | 0.0234264727644384 |
| GO:0004406 | H3/H4 histone acetyltransferase activity | 0.0323117080144102 |
| GO:0044427 | chromosomal part | 0.0385349237162417 |
| GO:0065003 | macromolecular complex assembly | 0.0407551671595038 |
| GO:0006334 | nucleosome assembly | 0.0407551671595038 |
| GO:0010467 | gene expression | 0.0407551671595038 |
| GO:0016874 | ligase activity | 0.0407551671595038 |
| GO:0004842 | ubiquitin-protein ligase activity | 0.0407551671595038 |
| GO:0000786 | nucleosome | 0.0407551671595038 |
| GO:0006610 | ribosomal protein import into nucleus | 0.0407551671595038 |
| GO:0008639 | small protein conjugating enzyme activity | 0.0413391853083521 |
| GO:0031497 | chromatin assembly | 0.0416704877530539 |
| GO:0005694 | chromosome | 0.0437425671811541 |
| GO:0043231 | intracellular membrane-bound organelle | 0.0437425671811541 |
| GO:0019787 | small conjugating protein ligase activity | 0.0437425671811541 |
| GO:0043227 | membrane-bound organelle | 0.0437425671811541 |
| GO:0022607 | cellular component assembly | 0.0437425671811541 |
| GO:0033036 | macromolecule localization | 0.0437425671811541 |
| GO:0065004 | protein-DNA complex assembly | 0.0437425671811541 |
| GO:0008536 | Ran GTPase binding | 0.0437425671811541 |
| GO:0016881 | acid-amino acid ligase activity | 0.0467068866387382 |
| GO:0050821 | protein stabilization | 0.0467068866387382 |
| GO:0042393 | histone binding | 0.0467068866387382 |
| GO:0006333 | chromatin assembly or disassembly | 0.0467102769164932 |
| GO:0043687 | post-translational protein modification | 0.0483164904506294 |
| GO:0031647 | regulation of protein stability | 0.0483164904506294 |
| GO:0016573 | histone acetylation | 0.0483164904506294 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| neuron | 5.58e-16 | 33 |
| neuronal stem cell | 5.58e-16 | 33 |
| neuroblast | 5.58e-16 | 33 |
| electrically signaling cell | 5.58e-16 | 33 |
| electrically responsive cell | 4.77e-13 | 39 |
| electrically active cell | 4.77e-13 | 39 |
| CNS neuron (sensu Vertebrata) | 1.05e-12 | 23 |
| neuroblast (sensu Vertebrata) | 1.05e-12 | 23 |
| ectodermal cell | 8.33e-10 | 44 |
| neurectodermal cell | 8.33e-10 | 44 |
| neural cell | 1.00e-09 | 43 |
| non-terminally differentiated cell | 3.36e-08 | 49 |
| Ontology term | p-value | n |
|---|---|---|
| neurectoderm | 3.81e-21 | 64 |
| neural plate | 3.81e-21 | 64 |
| presumptive neural plate | 3.81e-21 | 64 |
| central nervous system | 5.23e-21 | 73 |
| nervous system | 5.16e-20 | 75 |
| ectoderm-derived structure | 5.40e-20 | 95 |
| ectoderm | 5.40e-20 | 95 |
| presumptive ectoderm | 5.40e-20 | 95 |
| ecto-epithelium | 1.05e-18 | 73 |
| structure with developmental contribution from neural crest | 6.84e-18 | 92 |
| pre-chordal neural plate | 2.58e-17 | 49 |
| regional part of nervous system | 3.94e-17 | 54 |
| neural tube | 2.45e-16 | 52 |
| neural rod | 2.45e-16 | 52 |
| future spinal cord | 2.45e-16 | 52 |
| neural keel | 2.45e-16 | 52 |
| brain | 3.67e-14 | 47 |
| future brain | 3.67e-14 | 47 |
| anterior neural tube | 7.35e-14 | 40 |
| regional part of brain | 1.36e-13 | 46 |
| regional part of forebrain | 1.91e-13 | 39 |
| forebrain | 1.91e-13 | 39 |
| future forebrain | 1.91e-13 | 39 |
| gray matter | 6.95e-13 | 34 |
| brain grey matter | 1.78e-10 | 29 |
| regional part of telencephalon | 1.78e-10 | 29 |
| telencephalon | 1.78e-10 | 29 |
| multi-cellular organism | 4.95e-09 | 333 |
| embryo | 2.37e-08 | 320 |
| cerebral cortex | 4.66e-07 | 21 |
| cerebral hemisphere | 4.66e-07 | 21 |
| pallium | 4.66e-07 | 21 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 7.41658 |
| MA0004.1 | 0.118549 |
| MA0006.1 | 2.48471 |
| MA0007.1 | 0.356106 |
| MA0009.1 | 1.11793 |
| MA0014.1 | 5.27522 |
| MA0017.1 | 0.190692 |
| MA0019.1 | 0.290797 |
| MA0024.1 | 0.401898 |
| MA0025.1 | 0.645374 |
| MA0027.1 | 2.02409 |
| MA0028.1 | 0.691856 |
| MA0029.1 | 0.383872 |
| MA0030.1 | 0.389298 |
| MA0031.1 | 0.360121 |
| MA0038.1 | 0.209603 |
| MA0040.1 | 0.449452 |
| MA0041.1 | 0.272875 |
| MA0042.1 | 0.255859 |
| MA0043.1 | 0.522621 |
| MA0046.1 | 0.469568 |
| MA0048.1 | 1.56087 |
| MA0050.1 | 0.141024 |
| MA0051.1 | 0.617538 |
| MA0052.1 | 0.456356 |
| MA0055.1 | 1.00469 |
| MA0056.1 | 0 |
| MA0057.1 | 2.17998 |
| MA0058.1 | 0.24722 |
| MA0059.1 | 0.0759876 |
| MA0060.1 | 0.215905 |
| MA0061.1 | 0.0263971 |
| MA0063.1 | 0 |
| MA0066.1 | 0.20204 |
| MA0067.1 | 0.748059 |
| MA0068.1 | 1.1508 |
| MA0069.1 | 0.456647 |
| MA0070.1 | 0.448343 |
| MA0071.1 | 0.140522 |
| MA0072.1 | 0.44111 |
| MA0073.1 | 4.0252 |
| MA0074.1 | 0.178027 |
| MA0076.1 | 0.808369 |
| MA0077.1 | 0.422739 |
| MA0078.1 | 0.239324 |
| MA0081.1 | 0.611511 |
| MA0083.1 | 0.521922 |
| MA0084.1 | 1.0607 |
| MA0087.1 | 0.484199 |
| MA0088.1 | 0.759099 |
| MA0089.1 | 0 |
| MA0090.1 | 0.32897 |
| MA0091.1 | 0.125983 |
| MA0092.1 | 0.100239 |
| MA0093.1 | 0.181765 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.508591 |
| MA0101.1 | 0.274567 |
| MA0103.1 | 0.203213 |
| MA0105.1 | 0.223957 |
| MA0106.1 | 0.244965 |
| MA0107.1 | 0.0529506 |
| MA0108.2 | 0.308463 |
| MA0109.1 | 0 |
| MA0111.1 | 0.708981 |
| MA0113.1 | 0.224694 |
| MA0114.1 | 0.109084 |
| MA0115.1 | 0.525089 |
| MA0116.1 | 0.367847 |
| MA0117.1 | 0.496768 |
| MA0119.1 | 0.275337 |
| MA0122.1 | 0.514153 |
| MA0124.1 | 0.698593 |
| MA0125.1 | 0.630583 |
| MA0130.1 | 0 |
| MA0131.1 | 0.287321 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.554905 |
| MA0136.1 | 0.191208 |
| MA0139.1 | 1.5573 |
| MA0140.1 | 0.170444 |
| MA0141.1 | 0.0633664 |
| MA0142.1 | 0.34839 |
| MA0143.1 | 0.236381 |
| MA0144.1 | 0.270735 |
| MA0145.1 | 0.414538 |
| MA0146.1 | 2.36732 |
| MA0147.1 | 1.68084 |
| MA0148.1 | 0.127756 |
| MA0149.1 | 0.281823 |
| MA0062.2 | 0.926673 |
| MA0035.2 | 0.173482 |
| MA0039.2 | 3.5742 |
| MA0138.2 | 0.769269 |
| MA0002.2 | 0.169578 |
| MA0137.2 | 0.062153 |
| MA0104.2 | 1.69822 |
| MA0047.2 | 0.209072 |
| MA0112.2 | 1.09552 |
| MA0065.2 | 0.264546 |
| MA0150.1 | 0.355945 |
| MA0151.1 | 0 |
| MA0152.1 | 0.209147 |
| MA0153.1 | 0.569763 |
| MA0154.1 | 1.90914 |
| MA0155.1 | 2.73477 |
| MA0156.1 | 0.464199 |
| MA0157.1 | 0.322822 |
| MA0158.1 | 0 |
| MA0159.1 | 1.29831 |
| MA0160.1 | 0.129493 |
| MA0161.1 | 0 |
| MA0162.1 | 5.56595 |
| MA0163.1 | 8.77013 |
| MA0164.1 | 0.191451 |
| MA0080.2 | 0.197063 |
| MA0018.2 | 0.197998 |
| MA0099.2 | 0.276491 |
| MA0079.2 | 19.7748 |
| MA0102.2 | 1.11159 |
| MA0258.1 | 0.240529 |
| MA0259.1 | 0.813577 |
| MA0442.1 | 0 |
