MCL coexpression mm9:303
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0031527 | filopodium membrane | 0.00438284117679286 |
| GO:0032433 | filopodium tip | 0.00438284117679286 |
| GO:0046847 | filopodium formation | 0.0101871281319128 |
| GO:0022610 | biological adhesion | 0.0101871281319128 |
| GO:0007155 | cell adhesion | 0.0101871281319128 |
| GO:0030035 | microspike biogenesis | 0.0101871281319128 |
| GO:0031253 | cell projection membrane | 0.0101871281319128 |
| GO:0005391 | sodium:potassium-exchanging ATPase activity | 0.0101871281319128 |
| GO:0015075 | ion transmembrane transporter activity | 0.0101871281319128 |
| GO:0030175 | filopodium | 0.0101871281319128 |
| GO:0006811 | ion transport | 0.0101871281319128 |
| GO:0022891 | substrate-specific transmembrane transporter activity | 0.0101871281319128 |
| GO:0022857 | transmembrane transporter activity | 0.0126179115188622 |
| GO:0022892 | substrate-specific transporter activity | 0.0140635193250359 |
| GO:0030031 | cell projection biogenesis | 0.0258363874601177 |
| GO:0043168 | anion binding | 0.0258363874601177 |
| GO:0031404 | chloride ion binding | 0.0258363874601177 |
| GO:0005254 | chloride channel activity | 0.0258363874601177 |
| GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | 0.0258363874601177 |
| GO:0005253 | anion channel activity | 0.0258363874601177 |
| GO:0030424 | axon | 0.0258363874601177 |
| GO:0031589 | cell-substrate adhesion | 0.0258683639415299 |
| GO:0044463 | cell projection part | 0.0258683639415299 |
| GO:0031402 | sodium ion binding | 0.0283385692941129 |
| GO:0042625 | ATPase activity, coupled to transmembrane movement of ions | 0.0283385692941129 |
| GO:0030955 | potassium ion binding | 0.0316754946025582 |
| GO:0008509 | anion transmembrane transporter activity | 0.0316754946025582 |
| GO:0006814 | sodium ion transport | 0.0316754946025582 |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | 0.0316754946025582 |
| GO:0043492 | ATPase activity, coupled to movement of substances | 0.0316754946025582 |
| GO:0043005 | neuron projection | 0.0316754946025582 |
| GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances | 0.0316754946025582 |
| GO:0015399 | primary active transmembrane transporter activity | 0.0328854058322195 |
| GO:0015405 | P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.0328854058322195 |
| GO:0006810 | transport | 0.0349959185640569 |
| GO:0051234 | establishment of localization | 0.0358865332238167 |
| GO:0006813 | potassium ion transport | 0.0360963500426349 |
| GO:0031420 | alkali metal ion binding | 0.0406327701735411 |
| GO:0051179 | localization | 0.0422168481824396 |
| GO:0016337 | cell-cell adhesion | 0.0453230729897579 |
| GO:0042623 | ATPase activity, coupled | 0.0478091709644383 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 1.11e-09 | 23 |
| neuroblast (sensu Vertebrata) | 1.11e-09 | 23 |
| neural cell | 1.19e-08 | 43 |
| oligodendrocyte precursor cell | 2.96e-08 | 8 |
| ectodermal cell | 3.09e-08 | 44 |
| neurectodermal cell | 3.09e-08 | 44 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.136408 |
| MA0004.1 | 0.104042 |
| MA0006.1 | 0.0340907 |
| MA0007.1 | 0.319014 |
| MA0009.1 | 0.412602 |
| MA0014.1 | 0.0745092 |
| MA0017.1 | 0.666477 |
| MA0019.1 | 0.268299 |
| MA0024.1 | 0.37648 |
| MA0025.1 | 0.616209 |
| MA0027.1 | 1.99083 |
| MA0028.1 | 0.0372733 |
| MA0029.1 | 0.358857 |
| MA0030.1 | 0.364159 |
| MA0031.1 | 0.335674 |
| MA0038.1 | 0.190128 |
| MA0040.1 | 0.423075 |
| MA0041.1 | 3.73574 |
| MA0042.1 | 4.31671 |
| MA0043.1 | 0.495015 |
| MA0046.1 | 0.442826 |
| MA0048.1 | 0.0477447 |
| MA0050.1 | 1.86378 |
| MA0051.1 | 0.196084 |
| MA0052.1 | 0.429851 |
| MA0055.1 | 0.232377 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0953992 |
| MA0058.1 | 0.0597941 |
| MA0059.1 | 0.0648268 |
| MA0060.1 | 0.0692355 |
| MA0061.1 | 0.711233 |
| MA0063.1 | 0 |
| MA0066.1 | 0.182901 |
| MA0067.1 | 0.717937 |
| MA0068.1 | 1.99204 |
| MA0069.1 | 0.430137 |
| MA0070.1 | 0.421986 |
| MA0071.1 | 0.785781 |
| MA0072.1 | 0.414891 |
| MA0073.1 | 6.31849 |
| MA0074.1 | 1.49753 |
| MA0076.1 | 0.0491916 |
| MA0077.1 | 0.396883 |
| MA0078.1 | 0.62415 |
| MA0081.1 | 0.551199 |
| MA0083.1 | 0.494326 |
| MA0084.1 | 1.02883 |
| MA0087.1 | 0.457205 |
| MA0088.1 | 0.0452858 |
| MA0089.1 | 0 |
| MA0090.1 | 0.0869074 |
| MA0091.1 | 0.357896 |
| MA0092.1 | 0.612109 |
| MA0093.1 | 0.0399156 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.152909 |
| MA0101.1 | 0.068611 |
| MA0103.1 | 0.395656 |
| MA0105.1 | 1.39891 |
| MA0106.1 | 0.63693 |
| MA0107.1 | 0.168906 |
| MA0108.2 | 0.285422 |
| MA0109.1 | 0 |
| MA0111.1 | 1.07471 |
| MA0113.1 | 0.590844 |
| MA0114.1 | 0.43051 |
| MA0115.1 | 0.497446 |
| MA0116.1 | 0.0340292 |
| MA0117.1 | 0.469566 |
| MA0119.1 | 0.242709 |
| MA0122.1 | 0.486676 |
| MA0124.1 | 0.668899 |
| MA0125.1 | 0.601578 |
| MA0130.1 | 0 |
| MA0131.1 | 0.264933 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.526836 |
| MA0136.1 | 0.513613 |
| MA0139.1 | 0.135354 |
| MA0140.1 | 0.152839 |
| MA0141.1 | 2.17185 |
| MA0142.1 | 0.324241 |
| MA0143.1 | 0.215799 |
| MA0144.1 | 0.230788 |
| MA0145.1 | 1.20375 |
| MA0146.1 | 0.0351516 |
| MA0147.1 | 0.102772 |
| MA0148.1 | 0.112635 |
| MA0149.1 | 0.2488 |
| MA0062.2 | 0.029827 |
| MA0035.2 | 0.155719 |
| MA0039.2 | 0.520216 |
| MA0138.2 | 0.718426 |
| MA0002.2 | 0.0507616 |
| MA0137.2 | 0.194129 |
| MA0104.2 | 0.0596743 |
| MA0047.2 | 0.554999 |
| MA0112.2 | 0.935559 |
| MA0065.2 | 1.20812 |
| MA0150.1 | 0.0963127 |
| MA0151.1 | 0 |
| MA0152.1 | 0.189691 |
| MA0153.1 | 0.541494 |
| MA0154.1 | 1.04275 |
| MA0155.1 | 0.816297 |
| MA0156.1 | 0.724462 |
| MA0157.1 | 0.299365 |
| MA0158.1 | 0 |
| MA0159.1 | 4.38847 |
| MA0160.1 | 1.21328 |
| MA0161.1 | 0 |
| MA0162.1 | 0.802727 |
| MA0163.1 | 0.203588 |
| MA0164.1 | 0.514179 |
| MA0080.2 | 0.38483 |
| MA0018.2 | 0.179043 |
| MA0099.2 | 0.254459 |
| MA0079.2 | 0.843578 |
| MA0102.2 | 1.07954 |
| MA0258.1 | 0.648287 |
| MA0259.1 | 0.0938192 |
| MA0442.1 | 0 |
