MCL coexpression mm9:210
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006955 | immune response | 0.00826053774179675 |
GO:0002376 | immune system process | 0.0201741699337101 |
GO:0005634 | nucleus | 0.0240180846587962 |
GO:0005667 | transcription factor complex | 0.0240180846587962 |
GO:0002266 | follicular dendritic cell activation | 0.0240180846587962 |
GO:0002268 | follicular dendritic cell differentiation | 0.0240180846587962 |
GO:0004867 | serine-type endopeptidase inhibitor activity | 0.0240180846587962 |
GO:0044451 | nucleoplasm part | 0.0316694213930111 |
GO:0005654 | nucleoplasm | 0.0316694213930111 |
GO:0004866 | endopeptidase inhibitor activity | 0.0316694213930111 |
GO:0030414 | protease inhibitor activity | 0.0316694213930111 |
GO:0031981 | nuclear lumen | 0.0370814706951127 |
GO:0002467 | germinal center formation | 0.0370814706951127 |
GO:0048536 | spleen development | 0.0370814706951127 |
GO:0046983 | protein dimerization activity | 0.0370814706951127 |
GO:0004857 | enzyme inhibitor activity | 0.0370814706951127 |
GO:0000188 | inactivation of MAPK activity | 0.0370814706951127 |
GO:0031974 | membrane-enclosed lumen | 0.0370814706951127 |
GO:0043233 | organelle lumen | 0.0370814706951127 |
GO:0043234 | protein complex | 0.0370814706951127 |
GO:0003700 | transcription factor activity | 0.0440768544957696 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.0479074026411149 |
GO:0006351 | transcription, DNA-dependent | 0.0479074026411149 |
GO:0032774 | RNA biosynthetic process | 0.0479074026411149 |
GO:0043407 | negative regulation of MAP kinase activity | 0.0479074026411149 |
GO:0048535 | lymph node development | 0.0479074026411149 |
GO:0006094 | gluconeogenesis | 0.0479074026411149 |
GO:0045449 | regulation of transcription | 0.0479074026411149 |
GO:0043231 | intracellular membrane-bound organelle | 0.0479074026411149 |
GO:0043227 | membrane-bound organelle | 0.0479074026411149 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0479074026411149 |
GO:0044428 | nuclear part | 0.0479074026411149 |
GO:0006350 | transcription | 0.0479074026411149 |
GO:0006090 | pyruvate metabolic process | 0.0479074026411149 |
GO:0032991 | macromolecular complex | 0.0485576093868489 |
GO:0019319 | hexose biosynthetic process | 0.0485576093868489 |
GO:0010468 | regulation of gene expression | 0.0485576093868489 |
GO:0046165 | alcohol biosynthetic process | 0.0485576093868489 |
GO:0046364 | monosaccharide biosynthetic process | 0.0485576093868489 |
GO:0005515 | protein binding | 0.0485576093868489 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
intestinal epithelial cell | 5.45e-16 | 9 |
epithelial cell of alimentary canal | 5.45e-16 | 9 |
brush border epithelial cell | 1.49e-12 | 6 |
gut absorptive cell | 1.49e-12 | 6 |
absorptive cell | 1.49e-12 | 6 |
enterocyte | 1.49e-12 | 6 |
columnar/cuboidal epithelial cell | 9.89e-11 | 7 |
epithelial cell | 1.02e-10 | 25 |
hematopoietic cell | 1.66e-10 | 32 |
hematopoietic oligopotent progenitor cell | 1.66e-10 | 32 |
hematopoietic stem cell | 1.66e-10 | 32 |
angioblastic mesenchymal cell | 1.66e-10 | 32 |
hematopoietic multipotent progenitor cell | 1.66e-10 | 32 |
endo-epithelial cell | 2.94e-09 | 15 |
endodermal cell | 5.88e-09 | 20 |
somatic cell | 6.40e-09 | 118 |
animal cell | 3.13e-08 | 115 |
eukaryotic cell | 3.13e-08 | 115 |
connective tissue cell | 3.64e-08 | 46 |
mesenchymal cell | 3.64e-08 | 46 |
stem cell | 1.50e-07 | 97 |
Ontology term | p-value | n |
---|---|---|
epithelium of mucosa | 5.45e-16 | 9 |
gastrointestinal system epithelium | 5.45e-16 | 9 |
intestinal epithelium | 5.45e-16 | 9 |
simple columnar epithelium | 6.23e-13 | 11 |
intestinal mucosa | 8.20e-11 | 13 |
anatomical wall | 8.20e-11 | 13 |
wall of intestine | 8.20e-11 | 13 |
gastrointestinal system mucosa | 8.20e-11 | 13 |
mucosa | 2.94e-09 | 15 |
connective tissue | 3.64e-08 | 46 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.22497 |
MA0004.1 | 1.36286 |
MA0006.1 | 0.604557 |
MA0007.1 | 0.310419 |
MA0009.1 | 0.260251 |
MA0014.1 | 0.0217988 |
MA0017.1 | 0.462126 |
MA0019.1 | 0.144464 |
MA0024.1 | 0.65113 |
MA0025.1 | 2.91725 |
MA0027.1 | 1.78014 |
MA0028.1 | 1.62801 |
MA0029.1 | 0.215644 |
MA0030.1 | 0.219976 |
MA0031.1 | 0.196896 |
MA0038.1 | 0.619614 |
MA0040.1 | 0.741478 |
MA0041.1 | 0.0853046 |
MA0042.1 | 0.0766617 |
MA0043.1 | 1.58516 |
MA0046.1 | 0.285948 |
MA0048.1 | 0.20449 |
MA0050.1 | 2.06963 |
MA0051.1 | 1.57613 |
MA0052.1 | 3.86179 |
MA0055.1 | 0.050436 |
MA0056.1 | 0 |
MA0057.1 | 1.12335 |
MA0058.1 | 1.67524 |
MA0059.1 | 0.0802172 |
MA0060.1 | 0.188663 |
MA0061.1 | 9.12307 |
MA0063.1 | 0 |
MA0066.1 | 0.284669 |
MA0067.1 | 0.533552 |
MA0068.1 | 0.180141 |
MA0069.1 | 0.27511 |
MA0070.1 | 0.268186 |
MA0071.1 | 0.180115 |
MA0072.1 | 0.262182 |
MA0073.1 | 0.0594637 |
MA0074.1 | 0.521239 |
MA0076.1 | 1.11529 |
MA0077.1 | 0.247052 |
MA0078.1 | 0.108226 |
MA0081.1 | 0.238248 |
MA0083.1 | 0.330594 |
MA0084.1 | 0.829882 |
MA0087.1 | 0.29831 |
MA0088.1 | 0.520269 |
MA0089.1 | 0 |
MA0090.1 | 0.27877 |
MA0091.1 | 0.0401384 |
MA0092.1 | 0.116091 |
MA0093.1 | 1.30955 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.497838 |
MA0101.1 | 7.39609 |
MA0103.1 | 0.0520183 |
MA0105.1 | 4.56029 |
MA0106.1 | 0.729623 |
MA0107.1 | 13.0909 |
MA0108.2 | 1.48233 |
MA0109.1 | 0 |
MA0111.1 | 0.301903 |
MA0113.1 | 0.666587 |
MA0114.1 | 0.411227 |
MA0115.1 | 0.333331 |
MA0116.1 | 0.384308 |
MA0117.1 | 0.309003 |
MA0119.1 | 2.30433 |
MA0122.1 | 0.323899 |
MA0124.1 | 0.488052 |
MA0125.1 | 0.426393 |
MA0130.1 | 0 |
MA0131.1 | 0.437569 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.359267 |
MA0136.1 | 0.562317 |
MA0139.1 | 0.129996 |
MA0140.1 | 0.230166 |
MA0141.1 | 0.840721 |
MA0142.1 | 0.550541 |
MA0143.1 | 0.106237 |
MA0144.1 | 1.88116 |
MA0145.1 | 0.447193 |
MA0146.1 | 0.10275 |
MA0147.1 | 0.15457 |
MA0148.1 | 0.364643 |
MA0149.1 | 0.0203741 |
MA0062.2 | 0.533029 |
MA0035.2 | 1.31269 |
MA0039.2 | 0.178163 |
MA0138.2 | 0.426506 |
MA0002.2 | 1.02833 |
MA0137.2 | 1.54429 |
MA0104.2 | 0.16085 |
MA0047.2 | 0.0882619 |
MA0112.2 | 0.594441 |
MA0065.2 | 0.325578 |
MA0150.1 | 1.73983 |
MA0151.1 | 0 |
MA0152.1 | 0.297119 |
MA0153.1 | 0.972944 |
MA0154.1 | 0.59388 |
MA0155.1 | 0.289243 |
MA0156.1 | 0.788033 |
MA0157.1 | 0.168226 |
MA0158.1 | 0 |
MA0159.1 | 0.311625 |
MA0160.1 | 0.0419283 |
MA0161.1 | 0 |
MA0162.1 | 0.38346 |
MA0163.1 | 1.48657 |
MA0164.1 | 0.0771648 |
MA0080.2 | 0.478849 |
MA0018.2 | 2.0187 |
MA0099.2 | 4.13452 |
MA0079.2 | 0.489387 |
MA0102.2 | 0.879116 |
MA0258.1 | 0.366312 |
MA0259.1 | 1.19107 |
MA0442.1 | 0 |