MCL coexpression mm9:206
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0046655 | folic acid metabolic process | 0.0129926996099939 |
| GO:0006620 | posttranslational protein targeting to membrane | 0.0129926996099939 |
| GO:0008517 | folic acid transporter activity | 0.0129926996099939 |
| GO:0042744 | hydrogen peroxide catabolic process | 0.0129926996099939 |
| GO:0051183 | vitamin transporter activity | 0.0129926996099939 |
| GO:0051184 | cofactor transporter activity | 0.0129926996099939 |
| GO:0042743 | hydrogen peroxide metabolic process | 0.0129926996099939 |
| GO:0004602 | glutathione peroxidase activity | 0.0129926996099939 |
| GO:0042221 | response to chemical stimulus | 0.0129926996099939 |
| GO:0042542 | response to hydrogen peroxide | 0.0129926996099939 |
| GO:0005542 | folic acid binding | 0.0129926996099939 |
| GO:0006760 | folic acid and derivative metabolic process | 0.0131002542059473 |
| GO:0042558 | pteridine and derivative metabolic process | 0.0132689330088039 |
| GO:0015893 | drug transport | 0.0132689330088039 |
| GO:0015238 | drug transporter activity | 0.0133362479456937 |
| GO:0000302 | response to reactive oxygen species | 0.0142872710132106 |
| GO:0045047 | protein targeting to ER | 0.0159655011936602 |
| GO:0006612 | protein targeting to membrane | 0.0204800353436179 |
| GO:0006800 | oxygen and reactive oxygen species metabolic process | 0.0204800353436179 |
| GO:0042493 | response to drug | 0.0204800353436179 |
| GO:0008430 | selenium binding | 0.0204800353436179 |
| GO:0004601 | peroxidase activity | 0.0204800353436179 |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.0204800353436179 |
| GO:0006767 | water-soluble vitamin metabolic process | 0.0231875628053499 |
| GO:0006979 | response to oxidative stress | 0.0256762365123254 |
| GO:0006836 | neurotransmitter transport | 0.0263302697303201 |
| GO:0006752 | group transfer coenzyme metabolic process | 0.0285150748081131 |
| GO:0006766 | vitamin metabolic process | 0.0315564122737057 |
| GO:0046483 | heterocycle metabolic process | 0.0324268387677364 |
| GO:0019842 | vitamin binding | 0.049761938506236 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| primary circulatory organ | 1.31e-13 | 18 |
| heart | 1.31e-13 | 18 |
| primitive heart tube | 1.31e-13 | 18 |
| primary heart field | 1.31e-13 | 18 |
| anterior lateral plate mesoderm | 1.31e-13 | 18 |
| heart tube | 1.31e-13 | 18 |
| heart primordium | 1.31e-13 | 18 |
| cardiac mesoderm | 1.31e-13 | 18 |
| cardiogenic plate | 1.31e-13 | 18 |
| heart rudiment | 1.31e-13 | 18 |
| compound organ | 7.94e-12 | 43 |
| cardiovascular system | 7.82e-11 | 23 |
| circulatory system | 7.82e-11 | 23 |
| splanchnic layer of lateral plate mesoderm | 8.71e-11 | 33 |
| renal system | 2.44e-09 | 19 |
| urinary system structure | 7.07e-09 | 18 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.00338059 |
| MA0004.1 | 2.29507 |
| MA0006.1 | 0.00589647 |
| MA0007.1 | 0.125141 |
| MA0009.1 | 1.30463 |
| MA0014.1 | 1.47282e-06 |
| MA0017.1 | 0.682494 |
| MA0019.1 | 0.431774 |
| MA0024.1 | 0.224081 |
| MA0025.1 | 10.0976 |
| MA0027.1 | 1.77047 |
| MA0028.1 | 0.00680824 |
| MA0029.1 | 0.209792 |
| MA0030.1 | 0.214072 |
| MA0031.1 | 3.15542 |
| MA0038.1 | 0.287793 |
| MA0040.1 | 0.26267 |
| MA0041.1 | 0.396372 |
| MA0042.1 | 0.608649 |
| MA0043.1 | 0.324212 |
| MA0046.1 | 0.764888 |
| MA0048.1 | 6.72406e-05 |
| MA0050.1 | 0.0454501 |
| MA0051.1 | 0.0888408 |
| MA0052.1 | 0.268372 |
| MA0055.1 | 0.000837122 |
| MA0056.1 | 0 |
| MA0057.1 | 1.06442 |
| MA0058.1 | 4.84175 |
| MA0059.1 | 0.0164404 |
| MA0060.1 | 0.0357542 |
| MA0061.1 | 0.598813 |
| MA0063.1 | 0 |
| MA0066.1 | 0.0802142 |
| MA0067.1 | 0.525402 |
| MA0068.1 | 2.93713 |
| MA0069.1 | 0.268613 |
| MA0070.1 | 0.261756 |
| MA0071.1 | 0.0451909 |
| MA0072.1 | 0.710895 |
| MA0073.1 | 0.671846 |
| MA0074.1 | 0.0658239 |
| MA0076.1 | 0.0106166 |
| MA0077.1 | 0.24084 |
| MA0078.1 | 0.104095 |
| MA0081.1 | 0.0205896 |
| MA0083.1 | 0.323614 |
| MA0084.1 | 0.820891 |
| MA0087.1 | 0.291598 |
| MA0088.1 | 0.801574 |
| MA0089.1 | 0 |
| MA0090.1 | 0.797322 |
| MA0091.1 | 0.0378873 |
| MA0092.1 | 0.110074 |
| MA0093.1 | 2.98939 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.221405 |
| MA0101.1 | 0.0811847 |
| MA0103.1 | 0.473175 |
| MA0105.1 | 0.120794 |
| MA0106.1 | 0.107855 |
| MA0107.1 | 0.701354 |
| MA0108.2 | 0.152431 |
| MA0109.1 | 0 |
| MA0111.1 | 0.0292699 |
| MA0113.1 | 0.0945181 |
| MA0114.1 | 0.122857 |
| MA0115.1 | 0.326328 |
| MA0116.1 | 0.577014 |
| MA0117.1 | 0.816738 |
| MA0119.1 | 0.0180788 |
| MA0122.1 | 0.849992 |
| MA0124.1 | 0.480104 |
| MA0125.1 | 1.07455 |
| MA0130.1 | 0 |
| MA0131.1 | 0.137159 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.352071 |
| MA0136.1 | 0.25625 |
| MA0139.1 | 1.53702 |
| MA0140.1 | 0.481281 |
| MA0141.1 | 0.0121009 |
| MA0142.1 | 0.182284 |
| MA0143.1 | 0.102149 |
| MA0144.1 | 0.602162 |
| MA0145.1 | 0.0417674 |
| MA0146.1 | 0.00246926 |
| MA0147.1 | 0.00333186 |
| MA0148.1 | 0.63066 |
| MA0149.1 | 0.0189649 |
| MA0062.2 | 0.000284525 |
| MA0035.2 | 0.0631979 |
| MA0039.2 | 0.0460818 |
| MA0138.2 | 0.132863 |
| MA0002.2 | 0.530331 |
| MA0137.2 | 0.0117105 |
| MA0104.2 | 0.00790456 |
| MA0047.2 | 0.0845826 |
| MA0112.2 | 0.297406 |
| MA0065.2 | 2.16004 |
| MA0150.1 | 0.546596 |
| MA0151.1 | 0 |
| MA0152.1 | 0.084629 |
| MA0153.1 | 0.365019 |
| MA0154.1 | 0.10788 |
| MA0155.1 | 4.75379 |
| MA0156.1 | 0.142544 |
| MA0157.1 | 0.163022 |
| MA0158.1 | 0 |
| MA0159.1 | 0.705763 |
| MA0160.1 | 0.0396114 |
| MA0161.1 | 0 |
| MA0162.1 | 1.55039e-08 |
| MA0163.1 | 0.867997 |
| MA0164.1 | 0.0737651 |
| MA0080.2 | 0.128048 |
| MA0018.2 | 0.0777335 |
| MA0099.2 | 0.129496 |
| MA0079.2 | 0.00158798 |
| MA0102.2 | 0.870038 |
| MA0258.1 | 0.0437629 |
| MA0259.1 | 0.00277894 |
| MA0442.1 | 0 |
