MCL coexpression mm9:193
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006955 | immune response | 0.000339467542868089 |
GO:0002376 | immune system process | 0.000342132608125612 |
GO:0006954 | inflammatory response | 0.00323510684176256 |
GO:0009605 | response to external stimulus | 0.00787571199319539 |
GO:0009611 | response to wounding | 0.00913578151368008 |
GO:0005529 | sugar binding | 0.0181757919188123 |
GO:0045087 | innate immune response | 0.0275297211417301 |
GO:0030246 | carbohydrate binding | 0.0275297211417301 |
GO:0002274 | myeloid leukocyte activation | 0.0275297211417301 |
GO:0006950 | response to stress | 0.0275297211417301 |
GO:0008064 | regulation of actin polymerization and/or depolymerization | 0.0275297211417301 |
GO:0030832 | regulation of actin filament length | 0.0275297211417301 |
GO:0032535 | regulation of cellular component size | 0.0275297211417301 |
GO:0032956 | regulation of actin cytoskeleton organization and biogenesis | 0.0275297211417301 |
GO:0051493 | regulation of cytoskeleton organization and biogenesis | 0.0275297211417301 |
GO:0033043 | regulation of organelle organization and biogenesis | 0.0275297211417301 |
GO:0042222 | interleukin-1 biosynthetic process | 0.0275297211417301 |
GO:0050528 | acyloxyacyl hydrolase activity | 0.0275297211417301 |
GO:0006683 | galactosylceramide catabolic process | 0.0275297211417301 |
GO:0045360 | regulation of interleukin-1 biosynthetic process | 0.0275297211417301 |
GO:0045368 | positive regulation of interleukin-13 biosynthetic process | 0.0275297211417301 |
GO:0004336 | galactosylceramidase activity | 0.0275297211417301 |
GO:0042989 | sequestering of actin monomers | 0.0275297211417301 |
GO:0045362 | positive regulation of interleukin-1 biosynthetic process | 0.0275297211417301 |
GO:0030837 | negative regulation of actin filament polymerization | 0.0275297211417301 |
GO:0045366 | regulation of interleukin-13 biosynthetic process | 0.0275297211417301 |
GO:0004992 | platelet activating factor receptor activity | 0.0275297211417301 |
GO:0019376 | galactolipid catabolic process | 0.0275297211417301 |
GO:0008154 | actin polymerization and/or depolymerization | 0.031627873146193 |
GO:0030036 | actin cytoskeleton organization and biogenesis | 0.031627873146193 |
GO:0001843 | neural tube closure | 0.0342124694877948 |
GO:0030029 | actin filament-based process | 0.0351636572778514 |
GO:0014020 | primary neural tube formation | 0.0351636572778514 |
GO:0004872 | receptor activity | 0.0394984521570506 |
GO:0045523 | interleukin-27 receptor binding | 0.0394984521570506 |
GO:0042231 | interleukin-13 biosynthetic process | 0.0394984521570506 |
GO:0032616 | interleukin-13 production | 0.0394984521570506 |
GO:0046477 | glycosylceramide catabolic process | 0.0394984521570506 |
GO:0032612 | interleukin-1 production | 0.0394984521570506 |
GO:0051128 | regulation of cellular component organization and biogenesis | 0.0398073138868076 |
GO:0001841 | neural tube formation | 0.0398073138868076 |
GO:0001839 | neural plate morphogenesis | 0.0398073138868076 |
GO:0001840 | neural plate development | 0.0398073138868076 |
GO:0001838 | embryonic epithelial tube formation | 0.0398073138868076 |
GO:0031175 | neurite development | 0.0398073138868076 |
GO:0044425 | membrane part | 0.0398073138868076 |
GO:0006952 | defense response | 0.0398073138868076 |
GO:0016021 | integral to membrane | 0.0398073138868076 |
GO:0031224 | intrinsic to membrane | 0.0398073138868076 |
GO:0016337 | cell-cell adhesion | 0.0398073138868076 |
GO:0021860 | pyramidal neuron development | 0.0398073138868076 |
GO:0019374 | galactolipid metabolic process | 0.0398073138868076 |
GO:0006681 | galactosylceramide metabolic process | 0.0398073138868076 |
GO:0019364 | pyridine nucleotide catabolic process | 0.0398073138868076 |
GO:0006742 | NADP catabolic process | 0.0398073138868076 |
GO:0021859 | pyramidal neuron differentiation | 0.0398073138868076 |
GO:0042365 | water-soluble vitamin catabolic process | 0.0398073138868076 |
GO:0009111 | vitamin catabolic process | 0.0398073138868076 |
GO:0021915 | neural tube development | 0.0404889957359714 |
GO:0048666 | neuron development | 0.0420419331167892 |
GO:0051248 | negative regulation of protein metabolic process | 0.0426313595960248 |
GO:0004871 | signal transducer activity | 0.0426313595960248 |
GO:0060089 | molecular transducer activity | 0.0426313595960248 |
GO:0051246 | regulation of protein metabolic process | 0.0439426826011918 |
GO:0016331 | morphogenesis of embryonic epithelium | 0.0439426826011918 |
GO:0046521 | sphingoid catabolic process | 0.0439426826011918 |
GO:0031401 | positive regulation of protein modification process | 0.0439426826011918 |
GO:0016175 | superoxide-generating NADPH oxidase activity | 0.0439426826011918 |
GO:0050664 | oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor | 0.0439426826011918 |
GO:0046514 | ceramide catabolic process | 0.0439426826011918 |
GO:0003779 | actin binding | 0.0473986571630735 |
GO:0019903 | protein phosphatase binding | 0.0486320536389916 |
GO:0019377 | glycolipid catabolic process | 0.0486320536389916 |
GO:0006677 | glycosylceramide metabolic process | 0.0486320536389916 |
GO:0021884 | forebrain neuron development | 0.0486320536389916 |
GO:0007250 | activation of NF-kappaB-inducing kinase | 0.0486320536389916 |
GO:0031396 | regulation of protein ubiquitination | 0.0486320536389916 |
GO:0004839 | ubiquitin activating enzyme activity | 0.0486320536389916 |
GO:0008290 | F-actin capping protein complex | 0.0486320536389916 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
bone element | 9.43e-10 | 22 |
skeletal element | 9.43e-10 | 22 |
skeletal system | 9.43e-10 | 22 |
bone marrow | 1.76e-09 | 16 |
musculoskeletal system | 1.46e-08 | 32 |
hemolymphoid system | 2.30e-08 | 48 |
immune system | 2.30e-08 | 48 |
hematopoietic system | 2.76e-08 | 45 |
blood island | 2.76e-08 | 45 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.00594608 |
MA0004.1 | 0.103083 |
MA0006.1 | 0.0630352 |
MA0007.1 | 0.230767 |
MA0009.1 | 0.626825 |
MA0014.1 | 0.00109387 |
MA0017.1 | 0.333164 |
MA0019.1 | 0.366735 |
MA0024.1 | 0.191846 |
MA0025.1 | 0.389923 |
MA0027.1 | 1.7166 |
MA0028.1 | 0.159126 |
MA0029.1 | 0.178556 |
MA0030.1 | 0.537862 |
MA0031.1 | 0.486239 |
MA0038.1 | 0.505651 |
MA0040.1 | 0.646226 |
MA0041.1 | 0.789433 |
MA0042.1 | 1.04388 |
MA0043.1 | 0.286348 |
MA0046.1 | 0.243748 |
MA0048.1 | 0.11092 |
MA0050.1 | 2.25681 |
MA0051.1 | 1.86627 |
MA0052.1 | 0.233385 |
MA0055.1 | 0.00834441 |
MA0056.1 | 0 |
MA0057.1 | 0.0474366 |
MA0058.1 | 0.266397 |
MA0059.1 | 0.758219 |
MA0060.1 | 0.115486 |
MA0061.1 | 0.646624 |
MA0063.1 | 0 |
MA0066.1 | 0.222826 |
MA0067.1 | 0.480655 |
MA0068.1 | 0.00367073 |
MA0069.1 | 0.233612 |
MA0070.1 | 0.644206 |
MA0071.1 | 0.570233 |
MA0072.1 | 0.221558 |
MA0073.1 | 9.59247e-05 |
MA0074.1 | 0.416262 |
MA0076.1 | 0.0346709 |
MA0077.1 | 0.597811 |
MA0078.1 | 0.590813 |
MA0081.1 | 3.5587 |
MA0083.1 | 0.285777 |
MA0084.1 | 0.771136 |
MA0087.1 | 0.255344 |
MA0088.1 | 0.0140065 |
MA0089.1 | 0 |
MA0090.1 | 0.203942 |
MA0091.1 | 2.60031 |
MA0092.1 | 1.3376 |
MA0093.1 | 0.0773728 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.175296 |
MA0101.1 | 0.308279 |
MA0103.1 | 0.360915 |
MA0105.1 | 0.461948 |
MA0106.1 | 0.0860259 |
MA0107.1 | 0.344976 |
MA0108.2 | 0.125899 |
MA0109.1 | 0 |
MA0111.1 | 0.089074 |
MA0113.1 | 0.932684 |
MA0114.1 | 0.160957 |
MA0115.1 | 0.785414 |
MA0116.1 | 0.0197865 |
MA0117.1 | 0.2654 |
MA0119.1 | 0.153729 |
MA0122.1 | 0.765119 |
MA0124.1 | 0.436557 |
MA0125.1 | 0.377128 |
MA0130.1 | 0 |
MA0131.1 | 0.36088 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.312969 |
MA0136.1 | 1.20246 |
MA0139.1 | 0.0326105 |
MA0140.1 | 1.07988 |
MA0141.1 | 0.644982 |
MA0142.1 | 0.465684 |
MA0143.1 | 0.276987 |
MA0144.1 | 0.166521 |
MA0145.1 | 0.0381028 |
MA0146.1 | 0.000540238 |
MA0147.1 | 0.189638 |
MA0148.1 | 0.115196 |
MA0149.1 | 0.817527 |
MA0062.2 | 0.140963 |
MA0035.2 | 0.403512 |
MA0039.2 | 0.000723977 |
MA0138.2 | 0.108256 |
MA0002.2 | 0.97155 |
MA0137.2 | 0.0380226 |
MA0104.2 | 0.176484 |
MA0047.2 | 0.233733 |
MA0112.2 | 0.176376 |
MA0065.2 | 0.115284 |
MA0150.1 | 0.713794 |
MA0151.1 | 0 |
MA0152.1 | 0.0657833 |
MA0153.1 | 0.325381 |
MA0154.1 | 0.858671 |
MA0155.1 | 0.0135555 |
MA0156.1 | 1.53643 |
MA0157.1 | 0.421328 |
MA0158.1 | 0 |
MA0159.1 | 1.33859 |
MA0160.1 | 0.117517 |
MA0161.1 | 0 |
MA0162.1 | 0.000165977 |
MA0163.1 | 0.0157091 |
MA0164.1 | 0.206602 |
MA0080.2 | 0.804628 |
MA0018.2 | 0.0598662 |
MA0099.2 | 0.698339 |
MA0079.2 | 3.54578e-10 |
MA0102.2 | 3.18521 |
MA0258.1 | 0.137714 |
MA0259.1 | 0.0339619 |
MA0442.1 | 0 |