MCL coexpression mm9:186
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0019858 | cytosine metabolic process | 0.0346518380540185 |
GO:0045175 | basal protein localization | 0.0346518380540185 |
GO:0030950 | establishment and/or maintenance of actin cytoskeleton polarity | 0.0346518380540185 |
GO:0032879 | regulation of localization | 0.0346518380540185 |
GO:0030952 | establishment and/or maintenance of cytoskeleton polarity | 0.0346518380540185 |
GO:0032880 | regulation of protein localization | 0.0346518380540185 |
GO:0000228 | nuclear chromosome | 0.0390585294056866 |
GO:0007509 | mesoderm migration | 0.0390585294056866 |
GO:0008078 | mesodermal cell migration | 0.0390585294056866 |
GO:0007354 | zygotic determination of anterior/posterior axis, embryo | 0.0390585294056866 |
GO:0005123 | death receptor binding | 0.0390585294056866 |
GO:0007638 | mechanosensory behavior | 0.0390585294056866 |
GO:0048570 | notochord morphogenesis | 0.0390585294056866 |
GO:0048617 | embryonic foregut morphogenesis | 0.0390585294056866 |
GO:0010172 | embryonic body morphogenesis | 0.0390585294056866 |
GO:0004386 | helicase activity | 0.0390585294056866 |
GO:0032502 | developmental process | 0.0390585294056866 |
GO:0031575 | G1/S transition checkpoint | 0.0390585294056866 |
GO:0007440 | foregut morphogenesis | 0.0390585294056866 |
GO:0000578 | embryonic axis specification | 0.0390585294056866 |
GO:0008595 | determination of anterior/posterior axis, embryo | 0.0390585294056866 |
GO:0010171 | body morphogenesis | 0.0390585294056866 |
GO:0007351 | tripartite regional subdivision | 0.0390585294056866 |
GO:0005662 | DNA replication factor A complex | 0.0390585294056866 |
GO:0007350 | blastoderm segmentation | 0.0390585294056866 |
GO:0008625 | induction of apoptosis via death domain receptors | 0.0390585294056866 |
GO:0048611 | embryonic ectodermal gut development | 0.0390585294056866 |
GO:0016514 | SWI/SNF complex | 0.0390585294056866 |
GO:0001784 | phosphotyrosine binding | 0.0390585294056866 |
GO:0048613 | embryonic ectodermal gut morphogenesis | 0.0390585294056866 |
GO:0046332 | SMAD binding | 0.0390585294056866 |
GO:0030903 | notochord development | 0.0390585294056866 |
GO:0045176 | apical protein localization | 0.0390585294056866 |
GO:0006206 | pyrimidine base metabolic process | 0.0390585294056866 |
GO:0042074 | cell migration involved in gastrulation | 0.0390585294056866 |
GO:0045309 | protein phosphorylated amino acid binding | 0.0390585294056866 |
GO:0050821 | protein stabilization | 0.0390585294056866 |
GO:0048558 | embryonic gut morphogenesis | 0.0390585294056866 |
GO:0007399 | nervous system development | 0.0390585294056866 |
GO:0048340 | paraxial mesoderm morphogenesis | 0.0390585294056866 |
GO:0043601 | nuclear replisome | 0.0390585294056866 |
GO:0031647 | regulation of protein stability | 0.0390585294056866 |
GO:0018209 | peptidyl-serine modification | 0.0390585294056866 |
GO:0030894 | replisome | 0.0390585294056866 |
GO:0048557 | embryonic digestive tract morphogenesis | 0.0390585294056866 |
GO:0018105 | peptidyl-serine phosphorylation | 0.0390585294056866 |
GO:0008105 | asymmetric protein localization | 0.0390585294056866 |
GO:0007275 | multicellular organismal development | 0.0390585294056866 |
GO:0007439 | ectodermal gut development | 0.0398844424464048 |
GO:0043596 | nuclear replication fork | 0.0398844424464048 |
GO:0043330 | response to exogenous dsRNA | 0.0398844424464048 |
GO:0048567 | ectodermal gut morphogenesis | 0.0398844424464048 |
GO:0048547 | gut morphogenesis | 0.0408177928673203 |
GO:0009948 | anterior/posterior axis specification | 0.0408177928673203 |
GO:0014069 | postsynaptic density | 0.0408177928673203 |
GO:0003727 | single-stranded RNA binding | 0.0408177928673203 |
GO:0032496 | response to lipopolysaccharide | 0.0408177928673203 |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | 0.0408177928673203 |
GO:0007093 | mitotic cell cycle checkpoint | 0.0408177928673203 |
GO:0048546 | digestive tract morphogenesis | 0.0408177928673203 |
GO:0048339 | paraxial mesoderm development | 0.0408177928673203 |
GO:0035050 | embryonic heart tube development | 0.0408177928673203 |
GO:0048566 | embryonic gut development | 0.0408177928673203 |
GO:0043331 | response to dsRNA | 0.0408177928673203 |
GO:0051219 | phosphoprotein binding | 0.0408177928673203 |
GO:0004707 | MAP kinase activity | 0.0408177928673203 |
GO:0006974 | response to DNA damage stimulus | 0.0418893485611573 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.0428879313115443 |
GO:0043228 | non-membrane-bound organelle | 0.0428879313115443 |
GO:0030032 | lamellipodium biogenesis | 0.0437567641705426 |
GO:0009112 | nucleobase metabolic process | 0.0437567641705426 |
GO:0009719 | response to endogenous stimulus | 0.045387146081772 |
GO:0009798 | axis specification | 0.0458762410382874 |
GO:0007492 | endoderm development | 0.0458762410382874 |
GO:0002237 | response to molecule of bacterial origin | 0.0458762410382874 |
GO:0009612 | response to mechanical stimulus | 0.0458762410382874 |
GO:0005622 | intracellular | 0.0458762410382874 |
GO:0048565 | gut development | 0.0477566132305145 |
GO:0048523 | negative regulation of cellular process | 0.0491360628749696 |
GO:0008624 | induction of apoptosis by extracellular signals | 0.0491360628749696 |
GO:0016585 | chromatin remodeling complex | 0.0498390520962728 |
GO:0004860 | protein kinase inhibitor activity | 0.0498390520962728 |
GO:0003697 | single-stranded DNA binding | 0.0498390520962728 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
structure with developmental contribution from neural crest | 4.05e-12 | 92 |
tube | 1.80e-10 | 114 |
neurectoderm | 2.55e-10 | 64 |
neural plate | 2.55e-10 | 64 |
presumptive neural plate | 2.55e-10 | 64 |
embryo | 3.70e-10 | 320 |
regional part of nervous system | 4.74e-10 | 54 |
multi-cellular organism | 6.14e-10 | 333 |
pre-chordal neural plate | 2.12e-09 | 49 |
neural tube | 6.80e-09 | 52 |
neural rod | 6.80e-09 | 52 |
future spinal cord | 6.80e-09 | 52 |
neural keel | 6.80e-09 | 52 |
anatomical conduit | 1.07e-08 | 122 |
multi-tissue structure | 1.51e-08 | 230 |
occipital lobe | 4.08e-08 | 10 |
visual cortex | 4.08e-08 | 10 |
neocortex | 4.08e-08 | 10 |
brain | 4.37e-08 | 47 |
future brain | 4.37e-08 | 47 |
anterior neural tube | 5.13e-08 | 40 |
anatomical cluster | 7.97e-08 | 244 |
regional part of brain | 8.78e-08 | 46 |
gray matter | 9.52e-08 | 34 |
regional part of forebrain | 1.22e-07 | 39 |
forebrain | 1.22e-07 | 39 |
future forebrain | 1.22e-07 | 39 |
ecto-epithelium | 1.85e-07 | 73 |
central nervous system | 2.40e-07 | 73 |
brain grey matter | 4.53e-07 | 29 |
regional part of telencephalon | 4.53e-07 | 29 |
telencephalon | 4.53e-07 | 29 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 4.81021e-07 |
MA0004.1 | 0.22385 |
MA0006.1 | 0.0155406 |
MA0007.1 | 0.0796019 |
MA0009.1 | 0.591589 |
MA0014.1 | 1.44686e-06 |
MA0017.1 | 0.0694835 |
MA0019.1 | 0.691155 |
MA0024.1 | 0.177895 |
MA0025.1 | 0.371187 |
MA0027.1 | 1.69203 |
MA0028.1 | 0.00294766 |
MA0029.1 | 0.165083 |
MA0030.1 | 0.168911 |
MA0031.1 | 0.889488 |
MA0038.1 | 0.0583373 |
MA0040.1 | 0.212892 |
MA0041.1 | 1.75656 |
MA0042.1 | 0.948695 |
MA0043.1 | 0.269674 |
MA0046.1 | 1.20754 |
MA0048.1 | 0.0220791 |
MA0050.1 | 0.281042 |
MA0051.1 | 0.0614839 |
MA0052.1 | 0.218107 |
MA0055.1 | 0.492283 |
MA0056.1 | 0 |
MA0057.1 | 0.0340411 |
MA0058.1 | 0.109899 |
MA0059.1 | 0.254159 |
MA0060.1 | 0.000488428 |
MA0061.1 | 0.025515 |
MA0063.1 | 0 |
MA0066.1 | 0.774168 |
MA0067.1 | 0.460607 |
MA0068.1 | 0.0378703 |
MA0069.1 | 0.218327 |
MA0070.1 | 1.14552 |
MA0071.1 | 0.279746 |
MA0072.1 | 0.595735 |
MA0073.1 | 0.0560331 |
MA0074.1 | 0.37862 |
MA0076.1 | 0.00500926 |
MA0077.1 | 0.193028 |
MA0078.1 | 0.929178 |
MA0081.1 | 0.298309 |
MA0083.1 | 0.269117 |
MA0084.1 | 0.748608 |
MA0087.1 | 0.239452 |
MA0088.1 | 0.0662034 |
MA0089.1 | 0 |
MA0090.1 | 0.0681363 |
MA0091.1 | 0.242555 |
MA0092.1 | 0.178845 |
MA0093.1 | 0.271217 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0400425 |
MA0101.1 | 0.047449 |
MA0103.1 | 0.506077 |
MA0105.1 | 0.000543594 |
MA0106.1 | 0.0769837 |
MA0107.1 | 0.00406591 |
MA0108.2 | 0.114661 |
MA0109.1 | 0 |
MA0111.1 | 0.196615 |
MA0113.1 | 0.505855 |
MA0114.1 | 0.0640815 |
MA0115.1 | 0.271644 |
MA0116.1 | 0.0510887 |
MA0117.1 | 0.695708 |
MA0119.1 | 0.0477192 |
MA0122.1 | 0.262941 |
MA0124.1 | 1.07093 |
MA0125.1 | 0.358609 |
MA0130.1 | 0 |
MA0131.1 | 0.101573 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.802028 |
MA0136.1 | 0.0494027 |
MA0139.1 | 0.00813464 |
MA0140.1 | 0.156085 |
MA0141.1 | 0.0945839 |
MA0142.1 | 0.434397 |
MA0143.1 | 0.916952 |
MA0144.1 | 0.0668216 |
MA0145.1 | 0.000516404 |
MA0146.1 | 0.0208426 |
MA0147.1 | 0.158516 |
MA0148.1 | 0.24705 |
MA0149.1 | 0.0500219 |
MA0062.2 | 0.0107647 |
MA0035.2 | 0.655394 |
MA0039.2 | 1.64049e-06 |
MA0138.2 | 0.0979225 |
MA0002.2 | 0.0603574 |
MA0137.2 | 0.0920079 |
MA0104.2 | 0.0336124 |
MA0047.2 | 0.211312 |
MA0112.2 | 0.000110603 |
MA0065.2 | 0.0126727 |
MA0150.1 | 0.963185 |
MA0151.1 | 0 |
MA0152.1 | 0.463056 |
MA0153.1 | 0.829464 |
MA0154.1 | 0.000715729 |
MA0155.1 | 0.0407668 |
MA0156.1 | 0.0278399 |
MA0157.1 | 0.782378 |
MA0158.1 | 0 |
MA0159.1 | 0.0888074 |
MA0160.1 | 0.0238852 |
MA0161.1 | 0 |
MA0162.1 | 2.00448e-05 |
MA0163.1 | 0.000947515 |
MA0164.1 | 0.185637 |
MA0080.2 | 0.0238613 |
MA0018.2 | 0.0526357 |
MA0099.2 | 0.650672 |
MA0079.2 | 2.26757e-12 |
MA0102.2 | 0.796982 |
MA0258.1 | 0.0528736 |
MA0259.1 | 0.0264545 |
MA0442.1 | 0 |