MCL coexpression mm9:181
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0048646 | anatomical structure formation | 0.000497368783731777 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.00135038313484387 |
GO:0001525 | angiogenesis | 0.0013876934355548 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.002204301449548 |
GO:0048514 | blood vessel morphogenesis | 0.002204301449548 |
GO:0001568 | blood vessel development | 0.00310569406640817 |
GO:0001944 | vasculature development | 0.00310569406640817 |
GO:0051336 | regulation of hydrolase activity | 0.00853382769664921 |
GO:0030695 | GTPase regulator activity | 0.00934428635433393 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 0.0102117062414612 |
GO:0032502 | developmental process | 0.0109839690164534 |
GO:0009966 | regulation of signal transduction | 0.0109839690164534 |
GO:0007264 | small GTPase mediated signal transduction | 0.0109839690164534 |
GO:0043281 | regulation of caspase activity | 0.0109983096970839 |
GO:0007265 | Ras protein signal transduction | 0.0110827496733445 |
GO:0005083 | small GTPase regulator activity | 0.0110827496733445 |
GO:0009986 | cell surface | 0.0187754382056304 |
GO:0030334 | regulation of cell migration | 0.0218211564321479 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0218211564321479 |
GO:0007275 | multicellular organismal development | 0.0218211564321479 |
GO:0048731 | system development | 0.0218211564321479 |
GO:0035023 | regulation of Rho protein signal transduction | 0.0225900197786311 |
GO:0051270 | regulation of cell motility | 0.0225900197786311 |
GO:0009887 | organ morphogenesis | 0.0225900197786311 |
GO:0016512 | endothelin-converting enzyme 1 activity | 0.0225900197786311 |
GO:0016511 | endothelin-converting enzyme activity | 0.0225900197786311 |
GO:0015889 | cobalamin transport | 0.0225900197786311 |
GO:0040012 | regulation of locomotion | 0.0225900197786311 |
GO:0048513 | organ development | 0.0278753591736214 |
GO:0019199 | transmembrane receptor protein kinase activity | 0.0279995574557085 |
GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0279995574557085 |
GO:0050790 | regulation of catalytic activity | 0.0279995574557085 |
GO:0015087 | cobalt ion transmembrane transporter activity | 0.0279995574557085 |
GO:0016477 | cell migration | 0.0284174683586845 |
GO:0007266 | Rho protein signal transduction | 0.028898955822084 |
GO:0048856 | anatomical structure development | 0.0300318473563428 |
GO:0007242 | intracellular signaling cascade | 0.0300318473563428 |
GO:0006824 | cobalt ion transport | 0.0300318473563428 |
GO:0043154 | negative regulation of caspase activity | 0.0300318473563428 |
GO:0060037 | pharyngeal system development | 0.0300318473563428 |
GO:0051180 | vitamin transport | 0.0300318473563428 |
GO:0005615 | extracellular space | 0.0319250026199231 |
GO:0065009 | regulation of a molecular function | 0.0320554163701384 |
GO:0031419 | cobalamin binding | 0.032555283113838 |
GO:0017154 | semaphorin receptor activity | 0.032555283113838 |
GO:0006928 | cell motility | 0.032555283113838 |
GO:0051674 | localization of cell | 0.032555283113838 |
GO:0046578 | regulation of Ras protein signal transduction | 0.032555283113838 |
GO:0065007 | biological regulation | 0.0333028538379638 |
GO:0044421 | extracellular region part | 0.037021189567865 |
GO:0009653 | anatomical structure morphogenesis | 0.0387457327661686 |
GO:0016486 | peptide hormone processing | 0.0398379135829609 |
GO:0004245 | neprilysin activity | 0.0398379135829609 |
GO:0007413 | axonal fasciculation | 0.0398379135829609 |
GO:0004872 | receptor activity | 0.0435159628939011 |
GO:0030517 | negative regulation of axon extension | 0.0438789741123988 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
trunk region element | 3.93e-15 | 79 |
subdivision of trunk | 4.10e-13 | 66 |
trunk | 1.34e-11 | 90 |
multi-cellular organism | 2.55e-09 | 333 |
abdomen element | 2.96e-09 | 49 |
abdominal segment element | 2.96e-09 | 49 |
abdominal segment of trunk | 2.96e-09 | 49 |
abdomen | 2.96e-09 | 49 |
epithelial bud | 2.42e-08 | 17 |
epithelial tube | 2.89e-08 | 47 |
lung | 4.13e-08 | 14 |
respiratory tube | 4.13e-08 | 14 |
respiration organ | 4.13e-08 | 14 |
pair of lungs | 4.13e-08 | 14 |
lung primordium | 4.13e-08 | 14 |
lung bud | 4.13e-08 | 14 |
immaterial anatomical entity | 1.70e-07 | 79 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 1.85203 |
MA0004.1 | 0.0850481 |
MA0006.1 | 0.0477758 |
MA0007.1 | 0.194981 |
MA0009.1 | 0.580438 |
MA0014.1 | 0.826172 |
MA0017.1 | 0.670007 |
MA0019.1 | 0.10039 |
MA0024.1 | 0.173522 |
MA0025.1 | 0.957369 |
MA0027.1 | 1.68414 |
MA0028.1 | 1.13058 |
MA0029.1 | 0.484839 |
MA0030.1 | 0.164647 |
MA0031.1 | 0.444336 |
MA0038.1 | 0.205138 |
MA0040.1 | 0.599308 |
MA0041.1 | 0.123841 |
MA0042.1 | 0.409855 |
MA0043.1 | 0.264407 |
MA0046.1 | 0.223269 |
MA0048.1 | 1.10479 |
MA0050.1 | 0.271002 |
MA0051.1 | 1.23315 |
MA0052.1 | 1.799 |
MA0055.1 | 0.823641 |
MA0056.1 | 0 |
MA0057.1 | 0.464874 |
MA0058.1 | 0.006711 |
MA0059.1 | 0.116067 |
MA0060.1 | 0.162087 |
MA0061.1 | 0.540762 |
MA0063.1 | 0 |
MA0066.1 | 0.430967 |
MA0067.1 | 0.454225 |
MA0068.1 | 1.99865 |
MA0069.1 | 0.213518 |
MA0070.1 | 0.20731 |
MA0071.1 | 0.502438 |
MA0072.1 | 0.584554 |
MA0073.1 | 4.02163 |
MA0074.1 | 0.656103 |
MA0076.1 | 0.320993 |
MA0077.1 | 1.05282 |
MA0078.1 | 0.532513 |
MA0081.1 | 1.06164 |
MA0083.1 | 0.263855 |
MA0084.1 | 0.741403 |
MA0087.1 | 0.234442 |
MA0088.1 | 2.15699 |
MA0089.1 | 0 |
MA0090.1 | 0.338602 |
MA0091.1 | 0.233292 |
MA0092.1 | 0.171067 |
MA0093.1 | 0.0186182 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.038201 |
MA0101.1 | 0.259414 |
MA0103.1 | 0.0732674 |
MA0105.1 | 0.158934 |
MA0106.1 | 0.931599 |
MA0107.1 | 0.690461 |
MA0108.2 | 0.111172 |
MA0109.1 | 0 |
MA0111.1 | 0.368629 |
MA0113.1 | 0.22733 |
MA0114.1 | 1.90591 |
MA0115.1 | 0.266362 |
MA0116.1 | 1.06101 |
MA0117.1 | 0.244148 |
MA0119.1 | 0.451319 |
MA0122.1 | 0.257729 |
MA0124.1 | 0.410915 |
MA0125.1 | 0.352733 |
MA0130.1 | 0 |
MA0131.1 | 0.666005 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.290227 |
MA0136.1 | 2.05626 |
MA0139.1 | 0.290439 |
MA0140.1 | 0.624964 |
MA0141.1 | 0.194265 |
MA0142.1 | 0.136791 |
MA0143.1 | 0.0696137 |
MA0144.1 | 1.59697 |
MA0145.1 | 2.08833 |
MA0146.1 | 0.842116 |
MA0147.1 | 0.149252 |
MA0148.1 | 0.0958361 |
MA0149.1 | 0.715758 |
MA0062.2 | 0.915989 |
MA0035.2 | 0.993883 |
MA0039.2 | 0.113353 |
MA0138.2 | 0.649035 |
MA0002.2 | 0.441667 |
MA0137.2 | 0.189628 |
MA0104.2 | 0.228522 |
MA0047.2 | 0.0557325 |
MA0112.2 | 0.360635 |
MA0065.2 | 1.58448 |
MA0150.1 | 0.0756443 |
MA0151.1 | 0 |
MA0152.1 | 0.784105 |
MA0153.1 | 0.816944 |
MA0154.1 | 0.873893 |
MA0155.1 | 0.605127 |
MA0156.1 | 2.13347 |
MA0157.1 | 0.766219 |
MA0158.1 | 0 |
MA0159.1 | 0.288452 |
MA0160.1 | 0.0979124 |
MA0161.1 | 0 |
MA0162.1 | 0.0519345 |
MA0163.1 | 2.25628 |
MA0164.1 | 0.0474023 |
MA0080.2 | 1.62685 |
MA0018.2 | 0.0504369 |
MA0099.2 | 0.0919292 |
MA0079.2 | 2.36667 |
MA0102.2 | 0.789692 |
MA0258.1 | 0.192168 |
MA0259.1 | 0.0634865 |
MA0442.1 | 0 |