MCL coexpression mm9:158
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0000902 | cell morphogenesis | 0.000533580777143217 |
GO:0032989 | cellular structure morphogenesis | 0.000533580777143217 |
GO:0032990 | cell part morphogenesis | 0.00222883300916751 |
GO:0048858 | cell projection morphogenesis | 0.00222883300916751 |
GO:0030030 | cell projection organization and biogenesis | 0.00222883300916751 |
GO:0009953 | dorsal/ventral pattern formation | 0.00250566466836571 |
GO:0008092 | cytoskeletal protein binding | 0.0030975165027156 |
GO:0009653 | anatomical structure morphogenesis | 0.00428165185736983 |
GO:0009952 | anterior/posterior pattern formation | 0.00772921188679527 |
GO:0032502 | developmental process | 0.00772921188679527 |
GO:0005875 | microtubule associated complex | 0.00772921188679527 |
GO:0019987 | negative regulation of anti-apoptosis | 0.0101887099841072 |
GO:0003002 | regionalization | 0.0130979757035639 |
GO:0045767 | regulation of anti-apoptosis | 0.0130979757035639 |
GO:0007017 | microtubule-based process | 0.0152185007709145 |
GO:0048856 | anatomical structure development | 0.0152185007709145 |
GO:0005874 | microtubule | 0.0152185007709145 |
GO:0048523 | negative regulation of cellular process | 0.0152185007709145 |
GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 0.0152185007709145 |
GO:0031175 | neurite development | 0.0152185007709145 |
GO:0005856 | cytoskeleton | 0.0152185007709145 |
GO:0005523 | tropomyosin binding | 0.0152185007709145 |
GO:0016328 | lateral plasma membrane | 0.0152185007709145 |
GO:0048519 | negative regulation of biological process | 0.0152185007709145 |
GO:0048666 | neuron development | 0.0152185007709145 |
GO:0007275 | multicellular organismal development | 0.0152185007709145 |
GO:0005519 | cytoskeletal regulatory protein binding | 0.0152185007709145 |
GO:0032501 | multicellular organismal process | 0.0152185007709145 |
GO:0007389 | pattern specification process | 0.0152185007709145 |
GO:0030517 | negative regulation of axon extension | 0.0162885436067687 |
GO:0001578 | microtubule bundle formation | 0.0170820489591991 |
GO:0016043 | cellular component organization and biogenesis | 0.0170820489591991 |
GO:0043229 | intracellular organelle | 0.0170820489591991 |
GO:0043226 | organelle | 0.0170820489591991 |
GO:0050771 | negative regulation of axonogenesis | 0.0170820489591991 |
GO:0030182 | neuron differentiation | 0.0170820489591991 |
GO:0015630 | microtubule cytoskeleton | 0.0176965260044852 |
GO:0048699 | generation of neurons | 0.019838071825539 |
GO:0008013 | beta-catenin binding | 0.019838071825539 |
GO:0030308 | negative regulation of cell growth | 0.019838071825539 |
GO:0042384 | cilium biogenesis | 0.0203439537211195 |
GO:0030516 | regulation of axon extension | 0.0203439537211195 |
GO:0022008 | neurogenesis | 0.0211170800405944 |
GO:0009798 | axis specification | 0.0235708048326537 |
GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | 0.0243993736106459 |
GO:0045792 | negative regulation of cell size | 0.0251915549047828 |
GO:0050768 | negative regulation of neurogenesis | 0.0254090532441701 |
GO:0030176 | integral to endoplasmic reticulum membrane | 0.0254090532441701 |
GO:0048675 | axon extension | 0.0280400716874513 |
GO:0031227 | intrinsic to endoplasmic reticulum membrane | 0.0280400716874513 |
GO:0007270 | nerve-nerve synaptic transmission | 0.028681567037318 |
GO:0045926 | negative regulation of growth | 0.0288952341925234 |
GO:0007010 | cytoskeleton organization and biogenesis | 0.0288952341925234 |
GO:0043232 | intracellular non-membrane-bound organelle | 0.0288952341925234 |
GO:0043228 | non-membrane-bound organelle | 0.0288952341925234 |
GO:0005737 | cytoplasm | 0.0309652219385251 |
GO:0044424 | intracellular part | 0.0309652219385251 |
GO:0050794 | regulation of cellular process | 0.0309652219385251 |
GO:0050770 | regulation of axonogenesis | 0.0309652219385251 |
GO:0007368 | determination of left/right symmetry | 0.0337064694612772 |
GO:0044430 | cytoskeletal part | 0.0337064694612772 |
GO:0009799 | determination of symmetry | 0.0337064694612772 |
GO:0009855 | determination of bilateral symmetry | 0.0337064694612772 |
GO:0048731 | system development | 0.0337064694612772 |
GO:0005622 | intracellular | 0.0337064694612772 |
GO:0016358 | dendrite development | 0.0354045852839652 |
GO:0005871 | kinesin complex | 0.0354045852839652 |
GO:0050789 | regulation of biological process | 0.0396347683305164 |
GO:0050767 | regulation of neurogenesis | 0.0396347683305164 |
GO:0008017 | microtubule binding | 0.0399312795533295 |
GO:0030031 | cell projection biogenesis | 0.0405075994997916 |
GO:0007399 | nervous system development | 0.0405075994997916 |
GO:0031301 | integral to organelle membrane | 0.0415970681718946 |
GO:0030334 | regulation of cell migration | 0.042664658739414 |
GO:0031300 | intrinsic to organelle membrane | 0.0439205091015996 |
GO:0015631 | tubulin binding | 0.0439205091015996 |
GO:0043025 | cell soma | 0.0449141803985401 |
GO:0051270 | regulation of cell motility | 0.0458815245142755 |
GO:0040012 | regulation of locomotion | 0.0474634120728747 |
GO:0065007 | biological regulation | 0.0474634120728747 |
GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0474634120728747 |
GO:0003777 | microtubule motor activity | 0.0474634120728747 |
GO:0009967 | positive regulation of signal transduction | 0.0474634120728747 |
GO:0007611 | learning and/or memory | 0.0490427659683969 |
GO:0005789 | endoplasmic reticulum membrane | 0.0498775988954077 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
neuron | 1.94e-19 | 33 |
neuronal stem cell | 1.94e-19 | 33 |
neuroblast | 1.94e-19 | 33 |
electrically signaling cell | 1.94e-19 | 33 |
CNS neuron (sensu Vertebrata) | 1.42e-17 | 23 |
neuroblast (sensu Vertebrata) | 1.42e-17 | 23 |
electrically responsive cell | 2.99e-14 | 39 |
electrically active cell | 2.99e-14 | 39 |
neural cell | 5.64e-13 | 43 |
ectodermal cell | 2.28e-12 | 44 |
neurectodermal cell | 2.28e-12 | 44 |
non-terminally differentiated cell | 9.19e-10 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 2.97519e-12 |
MA0004.1 | 0.441617 |
MA0006.1 | 0.0176771 |
MA0007.1 | 0.0375296 |
MA0009.1 | 0.146696 |
MA0014.1 | 1.2145e-10 |
MA0017.1 | 0.140696 |
MA0019.1 | 0.0645494 |
MA0024.1 | 0.123939 |
MA0025.1 | 0.294662 |
MA0027.1 | 1.5868 |
MA0028.1 | 0.117444 |
MA0029.1 | 0.113321 |
MA0030.1 | 0.372307 |
MA0031.1 | 0.0998752 |
MA0038.1 | 0.0318222 |
MA0040.1 | 0.153528 |
MA0041.1 | 0.0189569 |
MA0042.1 | 0.234572 |
MA0043.1 | 0.203004 |
MA0046.1 | 0.166683 |
MA0048.1 | 0.00117255 |
MA0050.1 | 1.54777 |
MA0051.1 | 0.136578 |
MA0052.1 | 0.158003 |
MA0055.1 | 6.56596e-06 |
MA0056.1 | 0 |
MA0057.1 | 0.0127733 |
MA0058.1 | 0.0485457 |
MA0059.1 | 0.245599 |
MA0060.1 | 0.000716859 |
MA0061.1 | 0.584307 |
MA0063.1 | 0 |
MA0066.1 | 0.121134 |
MA0067.1 | 0.377729 |
MA0068.1 | 0.0524955 |
MA0069.1 | 0.478217 |
MA0070.1 | 0.152814 |
MA0071.1 | 0.547001 |
MA0072.1 | 0.14818 |
MA0073.1 | 4.05018e-15 |
MA0074.1 | 0.0220038 |
MA0076.1 | 0.0857009 |
MA0077.1 | 0.136635 |
MA0078.1 | 0.66736 |
MA0081.1 | 0.294591 |
MA0083.1 | 0.202511 |
MA0084.1 | 0.653563 |
MA0087.1 | 0.523136 |
MA0088.1 | 0.00220458 |
MA0089.1 | 0 |
MA0090.1 | 0.00556841 |
MA0091.1 | 0.0490708 |
MA0092.1 | 0.00559092 |
MA0093.1 | 0.12908 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0199292 |
MA0101.1 | 0.264042 |
MA0103.1 | 0.430377 |
MA0105.1 | 0.0123576 |
MA0106.1 | 0.0448166 |
MA0107.1 | 0.823476 |
MA0108.2 | 0.0729594 |
MA0109.1 | 0 |
MA0111.1 | 0.0356451 |
MA0113.1 | 0.0371177 |
MA0114.1 | 0.00146654 |
MA0115.1 | 0.204748 |
MA0116.1 | 0.00448519 |
MA0117.1 | 0.185022 |
MA0119.1 | 12.194 |
MA0122.1 | 0.197057 |
MA0124.1 | 0.894982 |
MA0125.1 | 0.77351 |
MA0130.1 | 0 |
MA0131.1 | 0.489255 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.226158 |
MA0136.1 | 0.795564 |
MA0139.1 | 0.000277496 |
MA0140.1 | 0.0882846 |
MA0141.1 | 0.19095 |
MA0142.1 | 0.643059 |
MA0143.1 | 0.3673 |
MA0144.1 | 2.91993 |
MA0145.1 | 0.00340254 |
MA0146.1 | 7.42518e-12 |
MA0147.1 | 0.0269572 |
MA0148.1 | 0.485531 |
MA0149.1 | 0.00346699 |
MA0062.2 | 0.000430175 |
MA0035.2 | 0.0207358 |
MA0039.2 | 7.39782e-10 |
MA0138.2 | 0.0601936 |
MA0002.2 | 1.43317 |
MA0137.2 | 1.92504 |
MA0104.2 | 0.00244373 |
MA0047.2 | 0.128932 |
MA0112.2 | 0.0495811 |
MA0065.2 | 0.00781621 |
MA0150.1 | 0.228441 |
MA0151.1 | 0 |
MA0152.1 | 0.305216 |
MA0153.1 | 0.237058 |
MA0154.1 | 0.0996113 |
MA0155.1 | 7.01026e-05 |
MA0156.1 | 0.0340626 |
MA0157.1 | 0.274456 |
MA0158.1 | 0 |
MA0159.1 | 0.234303 |
MA0160.1 | 0.0518289 |
MA0161.1 | 0 |
MA0162.1 | 0.000112584 |
MA0163.1 | 2.21698e-09 |
MA0164.1 | 1.15952 |
MA0080.2 | 0.073143 |
MA0018.2 | 0.0280116 |
MA0099.2 | 0.211271 |
MA0079.2 | 0 |
MA0102.2 | 0.700669 |
MA0258.1 | 0.0804071 |
MA0259.1 | 0.596925 |
MA0442.1 | 0 |