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MCL coexpression mm9:1321

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Phase1 CAGE Peaks

 Short description
Mm9::chr12:11303982..11303997,+p@chr12:11303982..11303997
+
Mm9::chr1:6239392..6239410,+p@chr1:6239392..6239410
+
Mm9::chr1:6239783..6239795,+p3@Rb1cc1
Mm9::chr1:93397379..93397436,+p@chr1:93397379..93397436
+
Mm9::chr4:32846086..32846098,+p@chr4:32846086..32846098
+
Mm9::chr4:83114536..83114556,-p@chr4:83114536..83114556
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0033238regulation of amine metabolic process0.000221879533604898
GO:0001932regulation of protein amino acid phosphorylation0.000221879533604898
GO:0006521regulation of amino acid metabolic process0.000221879533604898
GO:0042325regulation of phosphorylation0.000221879533604898
GO:0051174regulation of phosphorus metabolic process0.000221879533604898
GO:0019220regulation of phosphate metabolic process0.000221879533604898
GO:0042527negative regulation of tyrosine phosphorylation of Stat6 protein0.00175313647071714
GO:0042505tyrosine phosphorylation of Stat6 protein0.00175313647071714
GO:0042525regulation of tyrosine phosphorylation of Stat6 protein0.00175313647071714
GO:0006520amino acid metabolic process0.00187596919008826
GO:0007243protein kinase cascade0.00187596919008826
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation0.00242735323132255
GO:0042532negative regulation of tyrosine phosphorylation of STAT protein0.00242735323132255
GO:0006519amino acid and derivative metabolic process0.00244649972197393
GO:0009308amine metabolic process0.00262956062845648
GO:0046426negative regulation of JAK-STAT cascade0.00262956062845648
GO:0042326negative regulation of phosphorylation0.00262956062845648
GO:0045936negative regulation of phosphate metabolic process0.00262956062845648
GO:0006807nitrogen compound metabolic process0.002826711892783
GO:0045793positive regulation of cell size0.00393441923390635
GO:0019752carboxylic acid metabolic process0.00393441923390635
GO:0006082organic acid metabolic process0.00393441923390635
GO:0033239negative regulation of amine metabolic process0.00441717775500631
GO:0001933negative regulation of protein amino acid phosphorylation0.00441717775500631
GO:0045763negative regulation of amino acid metabolic process0.00441717775500631
GO:0042509regulation of tyrosine phosphorylation of STAT protein0.00546049743701293
GO:0006468protein amino acid phosphorylation0.00560096942145836
GO:0051101regulation of DNA binding0.00563369219311972
GO:0016310phosphorylation0.00630938947000794
GO:0007260tyrosine phosphorylation of STAT protein0.00630938947000794
GO:0046425regulation of JAK-STAT cascade0.006614501249939
GO:0006793phosphorus metabolic process0.00799947757455269
GO:0006796phosphate metabolic process0.00799947757455269
GO:0048523negative regulation of cellular process0.00849599447586067
GO:0051098regulation of binding0.00901143760694771
GO:0001889liver development0.00901569985682606
GO:0048519negative regulation of biological process0.00901569985682606
GO:0007242intracellular signaling cascade0.0101359222599567
GO:0001934positive regulation of protein amino acid phosphorylation0.0101359222599567
GO:0033240positive regulation of amine metabolic process0.0101359222599567
GO:0007259JAK-STAT cascade0.0101359222599567
GO:0045764positive regulation of amino acid metabolic process0.0101359222599567
GO:0050730regulation of peptidyl-tyrosine phosphorylation0.0124645301110032
GO:0043687post-translational protein modification0.0150596267028128
GO:0007254JNK cascade0.0150596267028128
GO:0031098stress-activated protein kinase signaling pathway0.0154234846140748
GO:0008017microtubule binding0.0154234846140748
GO:0015631tubulin binding0.017440087297816
GO:0018212peptidyl-tyrosine modification0.017440087297816
GO:0018108peptidyl-tyrosine phosphorylation0.017440087297816
GO:0006464protein modification process0.017440087297816
GO:0043412biopolymer modification0.0184414642376809
GO:0051248negative regulation of protein metabolic process0.0202066088147045
GO:0006355regulation of transcription, DNA-dependent0.0251870882483209
GO:0009968negative regulation of signal transduction0.0251870882483209
GO:0006351transcription, DNA-dependent0.0251870882483209
GO:0032774RNA biosynthetic process0.0251870882483209
GO:0018193peptidyl-amino acid modification0.0252358110631036
GO:0045449regulation of transcription0.0257142066931188
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0262942375471823
GO:0006350transcription0.0265444826573129
GO:0008361regulation of cell size0.0271510973585305
GO:0010468regulation of gene expression0.0274570777206803
GO:0045786negative regulation of progression through cell cycle0.0284016674325537
GO:0000165MAPKKK cascade0.0284016674325537
GO:0031323regulation of cellular metabolic process0.0284016674325537
GO:0019222regulation of metabolic process0.0300849551907664
GO:0016070RNA metabolic process0.0312280103520023
GO:0000122negative regulation of transcription from RNA polymerase II promoter0.0318918942274392
GO:0043066negative regulation of apoptosis0.0334186252039201
GO:0043069negative regulation of programmed cell death0.0334186252039201
GO:0007507heart development0.0370816770860599
GO:0000074regulation of progression through cell cycle0.0382863931188363
GO:0044267cellular protein metabolic process0.0391399300928187
GO:0045892negative regulation of transcription, DNA-dependent0.0391399300928187
GO:0044260cellular macromolecule metabolic process0.0394946093735333
GO:0010467gene expression0.0394946093735333
GO:0019538protein metabolic process0.040802127873492
GO:0051246regulation of protein metabolic process0.0456484403768468
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0460597258482257
GO:0016481negative regulation of transcription0.0460597258482257
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0487250302207857



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
tube7.13e-08114
occipital lobe6.01e-0710
visual cortex6.01e-0710
neocortex6.01e-0710


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.00973143
MA0004.10.536396
MA0006.10.359699
MA0007.10.52077
MA0009.10.987341
MA0014.10.0315641
MA0017.10.387481
MA0019.10.800946
MA0024.10.942716
MA0025.11.22395
MA0027.12.64231
MA0028.10.370592
MA0029.10.920529
MA0030.10.927235
MA0031.10.890871
MA0038.10.686534
MA0040.11.00009
MA0041.10.457338
MA0042.10.443591
MA0043.11.08567
MA0046.11.02391
MA0048.10.161427
MA0050.10.57678
MA0051.10.695779
MA0052.11.00829
MA0055.10.465302
MA0056.10
MA0057.10.149949
MA0058.10.436487
MA0059.10.449345
MA0060.10.275911
MA0061.10.307097
MA0063.10
MA0066.10.675169
MA0067.11.33603
MA0068.10.153907
MA0069.11.00864
MA0070.10.998765
MA0071.10.575909
MA0072.10.990133
MA0073.10.000157319
MA0074.10.638014
MA0076.10.407465
MA0077.10.968053
MA0078.11.73197
MA0081.10.473489
MA0083.11.08487
MA0084.11.66561
MA0087.11.04109
MA0088.10.111145
MA0089.10
MA0090.10.500693
MA0091.10.55008
MA0092.10.501022
MA0093.10.379257
MA0095.10
MA0098.10
MA0100.10.626021
MA0101.10.458688
MA0103.10.398766
MA0105.10.199622
MA0106.10.737893
MA0107.10.392331
MA0108.20.824407
MA0109.10
MA0111.10.515457
MA0113.10.708789
MA0114.10.304661
MA0115.11.08851
MA0116.10.359483
MA0117.11.05576
MA0119.10.459301
MA0122.11.07591
MA0124.11.28237
MA0125.11.20757
MA0130.10
MA0131.10.796279
MA0132.10
MA0133.10
MA0135.11.1226
MA0136.10.658622
MA0139.10.243463
MA0140.10.625902
MA0141.10.419361
MA0142.10.876028
MA0143.10.725672
MA0144.10.307873
MA0145.10.119202
MA0146.10.0392287
MA0147.10.320675
MA0148.10.553294
MA0149.10.464445
MA0062.20.204999
MA0035.20.630778
MA0039.20.00481054
MA0138.20.788113
MA0002.20.246463
MA0137.20.416331
MA0104.20.261255
MA0047.20.685741
MA0112.20.119197
MA0065.20.119561
MA0150.11.29346
MA0151.10
MA0152.10.685852
MA0153.11.13945
MA0154.10.159217
MA0155.10.132921
MA0156.10.406559
MA0157.10.843181
MA0158.10
MA0159.10.331229
MA0160.10.556423
MA0161.10
MA0162.10.0465447
MA0163.10.163321
MA0164.10.658997
MA0080.20.393257
MA0018.20.669032
MA0099.20.781628
MA0079.24.33609e-06
MA0102.21.7182
MA0258.10.290587
MA0259.10.309517
MA0442.10
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