Coexpression cluster:C329
From FANTOM5_SSTAR
Full id: C329_Neutrophils_CD14_Monocytederived_Whole_Peripheral_CD14CD16_Eosinophils
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0030595 | leukocyte chemotaxis | 0.00186465716784662 |
GO:0050900 | leukocyte migration | 0.00186465716784662 |
GO:0006928 | cell motility | 0.0026585079724821 |
GO:0051674 | localization of cell | 0.0026585079724821 |
GO:0042330 | taxis | 0.0136104827067435 |
GO:0006935 | chemotaxis | 0.0136104827067435 |
GO:0007626 | locomotory behavior | 0.0183273441445966 |
GO:0051179 | localization | 0.0183273441445966 |
GO:0048247 | lymphocyte chemotaxis | 0.0194971231181372 |
GO:0016477 | cell migration | 0.0194971231181372 |
GO:0007610 | behavior | 0.0194971231181372 |
GO:0015629 | actin cytoskeleton | 0.0194971231181372 |
GO:0005031 | tumor necrosis factor receptor activity | 0.0194971231181372 |
GO:0043531 | ADP binding | 0.0194971231181372 |
GO:0043120 | tumor necrosis factor binding | 0.0194971231181372 |
GO:0042994 | cytoplasmic sequestering of transcription factor | 0.0194971231181372 |
GO:0005515 | protein binding | 0.0194971231181372 |
GO:0005035 | death receptor activity | 0.0194971231181372 |
GO:0031941 | filamentous actin | 0.0194971231181372 |
GO:0051220 | cytoplasmic sequestering of protein | 0.0194971231181372 |
GO:0007159 | leukocyte adhesion | 0.0194971231181372 |
GO:0042308 | negative regulation of protein import into nucleus | 0.0194971231181372 |
GO:0005041 | low-density lipoprotein receptor activity | 0.0194971231181372 |
GO:0042992 | negative regulation of transcription factor import into nucleus | 0.0194971231181372 |
GO:0030228 | lipoprotein receptor activity | 0.0194971231181372 |
GO:0016043 | cellular component organization and biogenesis | 0.0194971231181372 |
GO:0030593 | neutrophil chemotaxis | 0.0194971231181372 |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 0.0194971231181372 |
GO:0051224 | negative regulation of protein transport | 0.020391741800133 |
GO:0000146 | microfilament motor activity | 0.0227406185699572 |
GO:0030048 | actin filament-based movement | 0.0230444884246312 |
GO:0003779 | actin binding | 0.0230444884246312 |
GO:0030169 | low-density lipoprotein binding | 0.0234255908084133 |
GO:0004871 | signal transducer activity | 0.0239176684604469 |
GO:0060089 | molecular transducer activity | 0.0239176684604469 |
GO:0005886 | plasma membrane | 0.024999223672671 |
GO:0042990 | regulation of transcription factor import into nucleus | 0.024999223672671 |
GO:0042991 | transcription factor import into nucleus | 0.024999223672671 |
GO:0042306 | regulation of protein import into nucleus | 0.024999223672671 |
GO:0033157 | regulation of intracellular protein transport | 0.024999223672671 |
GO:0005100 | Rho GTPase activator activity | 0.025245053130864 |
GO:0032507 | maintenance of cellular protein localization | 0.025245053130864 |
GO:0051651 | maintenance of cellular localization | 0.025245053130864 |
GO:0005884 | actin filament | 0.025245053130864 |
GO:0032386 | regulation of intracellular transport | 0.025245053130864 |
GO:0045185 | maintenance of protein localization | 0.0253332009963072 |
GO:0051223 | regulation of protein transport | 0.0253332009963072 |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 0.0253332009963072 |
GO:0006952 | defense response | 0.0253332009963072 |
GO:0042221 | response to chemical stimulus | 0.0253332009963072 |
GO:0046822 | regulation of nucleocytoplasmic transport | 0.0253332009963072 |
GO:0008034 | lipoprotein binding | 0.0253332009963072 |
GO:0008092 | cytoskeletal protein binding | 0.0259616498663089 |
GO:0051051 | negative regulation of transport | 0.026072739236562 |
GO:0009605 | response to external stimulus | 0.0274894677450028 |
GO:0051235 | maintenance of localization | 0.031240388662317 |
GO:0006898 | receptor-mediated endocytosis | 0.031240388662317 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 0.031240388662317 |
GO:0022603 | regulation of anatomical structure morphogenesis | 0.031240388662317 |
GO:0022604 | regulation of cell morphogenesis | 0.031240388662317 |
GO:0008360 | regulation of cell shape | 0.031240388662317 |
GO:0018212 | peptidyl-tyrosine modification | 0.032098748068781 |
GO:0001932 | regulation of protein amino acid phosphorylation | 0.032098748068781 |
GO:0033238 | regulation of amine metabolic process | 0.032098748068781 |
GO:0006521 | regulation of amino acid metabolic process | 0.032098748068781 |
GO:0008305 | integrin complex | 0.0377674227227657 |
GO:0019992 | diacylglycerol binding | 0.0397003874994354 |
GO:0006915 | apoptosis | 0.0397003874994354 |
GO:0012501 | programmed cell death | 0.0397411315633756 |
GO:0042325 | regulation of phosphorylation | 0.0402532619818485 |
GO:0048471 | perinuclear region of cytoplasm | 0.0402532619818485 |
GO:0005938 | cell cortex | 0.0402532619818485 |
GO:0008219 | cell death | 0.0405564525700531 |
GO:0016265 | death | 0.0405564525700531 |
GO:0046907 | intracellular transport | 0.0405564525700531 |
GO:0051174 | regulation of phosphorus metabolic process | 0.0405620894408165 |
GO:0019220 | regulation of phosphate metabolic process | 0.0405620894408165 |
GO:0006968 | cellular defense response | 0.041771960764272 |
GO:0005044 | scavenger receptor activity | 0.0418123338046793 |
GO:0008009 | chemokine activity | 0.0429751365009146 |
GO:0042379 | chemokine receptor binding | 0.0429992657534742 |
GO:0019901 | protein kinase binding | 0.0457603802830525 |
GO:0007229 | integrin-mediated signaling pathway | 0.0468307135085685 |
GO:0006606 | protein import into nucleus | 0.0496597971651375 |
GO:0051649 | establishment of cellular localization | 0.0496597971651375 |
GO:0004872 | receptor activity | 0.0496597971651375 |
GO:0051170 | nuclear import | 0.0496597971651375 |
GO:0019955 | cytokine binding | 0.0496597971651375 |
GO:0007160 | cell-matrix adhesion | 0.0496597971651375 |
GO:0019900 | kinase binding | 0.0496597971651375 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 3.61e-66 | 98 |
blood island | 3.61e-66 | 98 |
hemolymphoid system | 1.65e-61 | 108 |
bone marrow | 6.16e-57 | 76 |
immune system | 4.36e-53 | 93 |
bone element | 2.33e-51 | 82 |
skeletal element | 4.40e-45 | 90 |
skeletal system | 1.15e-38 | 100 |
lateral plate mesoderm | 4.49e-22 | 203 |
musculoskeletal system | 1.23e-16 | 167 |
connective tissue | 2.57e-12 | 371 |
mesoderm | 7.67e-09 | 315 |
mesoderm-derived structure | 7.67e-09 | 315 |
presumptive mesoderm | 7.67e-09 | 315 |
blood | 1.64e-08 | 15 |
haemolymphatic fluid | 1.64e-08 | 15 |
organism substance | 1.64e-08 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.145782 |
MA0004.1 | 0.250106 |
MA0006.1 | 0.0931752 |
MA0007.1 | 1.2868 |
MA0009.1 | 0.366503 |
MA0014.1 | 0.157527 |
MA0017.1 | 1.25224 |
MA0019.1 | 0.145319 |
MA0024.1 | 0.77938 |
MA0025.1 | 0.47683 |
MA0027.1 | 1.89328 |
MA0028.1 | 0.483716 |
MA0029.1 | 0.812088 |
MA0030.1 | 0.291553 |
MA0031.1 | 0.24472 |
MA0038.1 | 0.120244 |
MA0040.1 | 0.304553 |
MA0041.1 | 0.970425 |
MA0042.1 | 0.867824 |
MA0043.1 | 0.366755 |
MA0046.1 | 0.357837 |
MA0048.1 | 0.547696 |
MA0050.1 | 0.507351 |
MA0051.1 | 0.376278 |
MA0052.1 | 0.828653 |
MA0055.1 | 1.64945 |
MA0056.1 | 0 |
MA0057.1 | 0.0701724 |
MA0058.1 | 0.148161 |
MA0059.1 | 0.340565 |
MA0060.1 | 0.0046941 |
MA0061.1 | 0.0571069 |
MA0063.1 | 0 |
MA0066.1 | 1.82484 |
MA0067.1 | 0.638784 |
MA0068.1 | 0.0795413 |
MA0069.1 | 0.354782 |
MA0070.1 | 0.345954 |
MA0071.1 | 0.675927 |
MA0072.1 | 0.342425 |
MA0073.1 | 0.405206 |
MA0074.1 | 0.754649 |
MA0076.1 | 0.16355 |
MA0077.1 | 0.336397 |
MA0078.1 | 0.520188 |
MA0081.1 | 0.147095 |
MA0083.1 | 0.372513 |
MA0084.1 | 0.811454 |
MA0087.1 | 0.340509 |
MA0088.1 | 0.335716 |
MA0089.1 | 0 |
MA0090.1 | 1.09175 |
MA0091.1 | 0.539562 |
MA0092.1 | 0.209949 |
MA0093.1 | 0.236964 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.40142 |
MA0101.1 | 0.0226238 |
MA0103.1 | 1.39112 |
MA0105.1 | 0.18719 |
MA0106.1 | 2.01161 |
MA0107.1 | 0.0495017 |
MA0108.2 | 0.242565 |
MA0109.1 | 0 |
MA0111.1 | 2.14027 |
MA0113.1 | 0.152632 |
MA0114.1 | 1.01377 |
MA0115.1 | 0.570409 |
MA0116.1 | 0.286939 |
MA0117.1 | 0.396851 |
MA0119.1 | 0.569091 |
MA0122.1 | 0.418111 |
MA0124.1 | 0.533912 |
MA0125.1 | 0.461632 |
MA0130.1 | 0 |
MA0131.1 | 0.548008 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.390959 |
MA0136.1 | 0.391883 |
MA0139.1 | 0.79031 |
MA0140.1 | 0.326417 |
MA0141.1 | 0.609947 |
MA0142.1 | 0.222682 |
MA0143.1 | 1.45411 |
MA0144.1 | 0.932046 |
MA0145.1 | 0.180161 |
MA0146.1 | 0.487922 |
MA0147.1 | 0.145252 |
MA0148.1 | 0.280213 |
MA0149.1 | 0.0944562 |
MA0062.2 | 0.236276 |
MA0035.2 | 0.325494 |
MA0039.2 | 0.0240301 |
MA0138.2 | 1.59073 |
MA0002.2 | 0.472005 |
MA0137.2 | 0.50116 |
MA0104.2 | 0.176968 |
MA0047.2 | 0.422993 |
MA0112.2 | 0.67359 |
MA0065.2 | 0.760568 |
MA0150.1 | 0.172115 |
MA0151.1 | 0 |
MA0152.1 | 0.102351 |
MA0153.1 | 0.447419 |
MA0154.1 | 0.17951 |
MA0155.1 | 1.01122 |
MA0156.1 | 0.507342 |
MA0157.1 | 0.204296 |
MA0158.1 | 0 |
MA0159.1 | 1.08772 |
MA0160.1 | 0.621983 |
MA0161.1 | 0 |
MA0162.1 | 0.00480139 |
MA0163.1 | 0.667329 |
MA0164.1 | 0.482782 |
MA0080.2 | 1.07037 |
MA0018.2 | 0.143876 |
MA0099.2 | 0.335524 |
MA0079.2 | 0.00143571 |
MA0102.2 | 0.846442 |
MA0258.1 | 0.387384 |
MA0259.1 | 0.531383 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.