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UBERON:0002048

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Name:lung
Definition:"Respiration organ present in all air-breathing animals whose principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere[WP]. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax[GO]." [BTO:0000763, Wikipedia:Lung]
Xrefs:
links:

AAO:0000275
AAO:0010567
BTO:0000763
EFO:0000934
EHDAA:1554
EHDAA:2205
EHDAA2:0001042
EMAPA:16728
EV:0100042
FMA:7195
GAID:345
galen:Lung
MA:0000415
MAT:0000135
MESH:A.04.411
MIAA:0000135
ncithesaurus:Lung
OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA
SCTID:181216001

XAO:0000119
Comments:respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi // Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]
Alt_id: UBERON:FMA_68877-FMA_7195-MA_0000415-MIAA_0000135-XAO_0000119
Subset: major_organ
organ_slim
uberon_slim

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000077(mixed endoderm/mesoderm-derived structure),UBERON:0000117(respiratory tube),UBERON:0000171(respiration organ),UBERON:0005178(thoracic cavity element)
develops_from:UBERON:0000118(lung bud)
part_of:UBERON:0000170(pair of lungs),UBERON:0002224(thoracic cavity)



Children

is a:UBERON:0002167 (right lung)
derives from:FF:0010019 (human lung - adult sample),FF:0010068 (human lung - fetal sample),FF:0011307 (mouse lung- adult sample),FF:0011319 (mouse lung- embryo E12 sample),FF:0011338 (mouse lung- embryo E14 sample),FF:0011348 (mouse lung- embryo E15 sample),FF:0011357 (mouse lung- embryo E16 sample),FF:0011368 (mouse lung- embryo E17 sample),FF:0011394 (mouse lung- neonate N00 sample),FF:0011402 (mouse lung- neonate N06 sample),FF:0011408 (mouse lung- neonate N07 sample),FF:0011415 (mouse lung- neonate N10 sample),FF:0011428 (mouse lung- neonate N20 sample),FF:0011488 (mouse lung- neonate N25 sample),FF:0011489 (mouse lung- neonate N30 sample),FF:0011513 (mouse lung- embryo E18 sample),FF:0100353 (lung cell line sample)
part of:CL:0000082 (epithelial cell of lung),UBERON:0000101 (lobe of lung),UBERON:0000115 (lung epithelium),UBERON:0002173 (alveolar duct),UBERON:0002186 (bronchiole),UBERON:0002299 (alveolus of lung),CL:0002553 (lung fibroblast),UBERON:0006524 (alveolar system),UBERON:0008874 (pulmonary acinus),UBERON:0010368 (pulmonary lobule)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002048 (lung), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.5e-81FFCP PHASE1:Mm9::chr11:85703335..85703350,+#_219ec111849cbff5792f352d28b3b951p4@Tbx4
3.5e-81FFCP PHASE2:Mm9::chr11:85703335..85703350,+#_219ec111849cbff5792f352d28b3b951p4@Tbx4
1.94e-76FFCP PHASE1:Mm9::chr11:85589157..85589190,-#_728abddb49b1e53cc00a266460b676bap1@ENSMUST00000134305
1.94e-76FFCP PHASE2:Mm9::chr11:85589157..85589190,-#_728abddb49b1e53cc00a266460b676bap1@ENSMUST00000134305
6.06e-75FFCP PHASE1:Mm9::chr11:85533239..85533252,-#_bdb69024b7792d06938403e5ab8c2e95p1@ENSMUST00000146806, p1@ENSMUST00000151652, p1@uc007krv.1, p1@uc007krw.1
6.06e-75FFCP PHASE2:Mm9::chr11:85533239..85533252,-#_bdb69024b7792d06938403e5ab8c2e95p1@ENSMUST00000146806, p1@ENSMUST00000151652, p1@uc007krv.1, p1@uc007krw.1
7.98e-75FFCP PHASE2:Mm9::chr11:85699562..85699575,+#_26099c5b79e5951186e3f10ac8607db3p6@Tbx4
7.98e-75FFCP PHASE1:Mm9::chr11:85699562..85699575,+#_26099c5b79e5951186e3f10ac8607db3p6@Tbx4
3.64e-74FFCP PHASE2:Mm9::chr4:138812977..138812992,+#_9564d34bec03a78a2521740dde0ec5f4p@chr4:138812977..138812992, +
3.64e-74FFCP PHASE2:Mm9::chr8:94878479..94878503,-#_9564d34bec03a78a2521740dde0ec5f4p@chr8:94878479..94878503, -
3.64e-74FFCP PHASE1:Mm9::chr4:138812977..138812992,+#_9564d34bec03a78a2521740dde0ec5f4p@chr4:138812977..138812992, +
3.64e-74FFCP PHASE2:Mm9::chr11:59457994..59457997,-#_9564d34bec03a78a2521740dde0ec5f4p@chr11:59457994..59457997, -
3.64e-74FFCP PHASE2:Mm9::chr12:57636003..57636017,-#_9564d34bec03a78a2521740dde0ec5f4p@chr12:57636003..57636017, -
3.64e-74FFCP PHASE1:Mm9::chr12:57636003..57636017,-#_9564d34bec03a78a2521740dde0ec5f4p@chr12:57636003..57636017, -
3.64e-74FFCP PHASE1:Mm9::chr11:59457994..59457997,-#_9564d34bec03a78a2521740dde0ec5f4p@chr11:59457994..59457997, -
3.64e-74FFCP PHASE1:Mm9::chr12:57598716..57598720,-#_9564d34bec03a78a2521740dde0ec5f4p@chr12:57598716..57598720, -
3.64e-74FFCP PHASE2:Mm9::chr12:57598716..57598720,-#_9564d34bec03a78a2521740dde0ec5f4p@chr12:57598716..57598720, -
3.64e-74FFCP PHASE1:Mm9::chr8:94878479..94878503,-#_9564d34bec03a78a2521740dde0ec5f4p@chr8:94878479..94878503, -
3.06e-70FFCP PHASE1:Mm9::chr12:57637649..57637665,-#_16157ceef2bf7b42c042c76b33042366p8@Nkx2-1
3.06e-70FFCP PHASE2:Mm9::chr12:57637649..57637665,-#_16157ceef2bf7b42c042c76b33042366p8@Nkx2-1
3.48e-70FFCP PHASE2:Mm9::chr12:57630487..57630498,-#_6dbeae56c1d4f8c119ef65927c6dc7aap2@E030019B13Rik
3.48e-70FFCP PHASE1:Mm9::chr12:57630487..57630498,-#_6dbeae56c1d4f8c119ef65927c6dc7aap2@E030019B13Rik
3.96e-70FFCP PHASE1:Mm9::chr2:17653019..17653038,-#_d90e8765ec106ab3d94f54f750ed7cccp10@Nebl
3.96e-70FFCP PHASE2:Mm9::chr2:17653019..17653038,-#_d90e8765ec106ab3d94f54f750ed7cccp10@Nebl
4.5e-70FFCP PHASE2:Mm9::chr12:57637700..57637717,-#_38b1fd967c6444dc97bd3a3c8b03cd3ep9@Nkx2-1
4.5e-70FFCP PHASE1:Mm9::chr12:57637700..57637717,-#_38b1fd967c6444dc97bd3a3c8b03cd3ep9@Nkx2-1
9.69e-69FFCP PHASE1:Mm9::chr19:18833097..18833135,+#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p3@Trpm6
9.69e-69FFCP PHASE1:Mm9::chr12:57598537..57598547,-#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p@chr12:57598537..57598547, -
9.69e-69FFCP PHASE2:Mm9::chr19:18833097..18833135,+#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p3@Trpm6
9.69e-69FFCP PHASE2:Mm9::chr12:57598537..57598547,-#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p@chr12:57598537..57598547, -
9.69e-69FFCP PHASE1:Mm9::chr12:57630364..57630373,-#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p3@E030019B13Rik
9.69e-69FFCP PHASE2:Mm9::chr12:57630364..57630373,-#_30b80d1b1f5fd4bd0f5956d9e0b04fd0p3@E030019B13Rik
1.11e-68FFCP PHASE1:Mm9::chr14:115241755..115241762,-#_789e7f56eae9c96f0b2d9a25f52fb734p@chr14:115241755..115241762, -
1.11e-68FFCP PHASE2:Mm9::chr14:115241755..115241762,-#_789e7f56eae9c96f0b2d9a25f52fb734p@chr14:115241755..115241762, -
1.27e-68FFCP PHASE2:Mm9::chr4:138812999..138813015,+#_d0f5fca9765aff09dc056f1e56acdf4bp@chr4:138812999..138813015, +
1.27e-68FFCP PHASE1:Mm9::chr4:138812999..138813015,+#_d0f5fca9765aff09dc056f1e56acdf4bp@chr4:138812999..138813015, +
4.47e-68FFCP PHASE2:Mm9::chr5:120282691..120282701,+#_0656af5a30499007d23183f04bea31cdp@chr5:120282691..120282701, +
4.47e-68FFCP PHASE1:Mm9::chr5:120282691..120282701,+#_0656af5a30499007d23183f04bea31cdp@chr5:120282691..120282701, +
5.44e-68FFCP PHASE1:Mm9::chr14:70922576..70922589,-#_78f8eb39883610a9976b03a984ecc6e9p@chr14:70922576..70922589, -
5.44e-68FFCP PHASE1:Mm9::chr6:72256828..72256859,+#_78f8eb39883610a9976b03a984ecc6e9p3@Sftpb
5.44e-68FFCP PHASE2:Mm9::chr2:66524237..66524246,-#_78f8eb39883610a9976b03a984ecc6e9p@chr2:66524237..66524246, -
5.44e-68FFCP PHASE1:Mm9::chr1:184610062..184610074,+#_78f8eb39883610a9976b03a984ecc6e9p@chr1:184610062..184610074, +
5.44e-68FFCP PHASE1:Mm9::chr14:70921265..70921285,-#_78f8eb39883610a9976b03a984ecc6e9p@chr14:70921265..70921285, -
5.44e-68FFCP PHASE1:Mm9::chr6:72255924..72255936,+#_78f8eb39883610a9976b03a984ecc6e9p4@Sftpb
5.44e-68FFCP PHASE2:Mm9::chr1:184610062..184610074,+#_78f8eb39883610a9976b03a984ecc6e9p@chr1:184610062..184610074, +
5.44e-68FFCP PHASE2:Mm9::chr14:70922576..70922589,-#_78f8eb39883610a9976b03a984ecc6e9p@chr14:70922576..70922589, -
5.44e-68FFCP PHASE1:Mm9::chr2:66524237..66524246,-#_78f8eb39883610a9976b03a984ecc6e9p@chr2:66524237..66524246, -
5.44e-68FFCP PHASE2:Mm9::chr14:70921265..70921285,-#_78f8eb39883610a9976b03a984ecc6e9p@chr14:70921265..70921285, -
5.44e-68FFCP PHASE2:Mm9::chr6:72255924..72255936,+#_78f8eb39883610a9976b03a984ecc6e9p4@Sftpb
5.44e-68FFCP PHASE2:Mm9::chr6:72256828..72256859,+#_78f8eb39883610a9976b03a984ecc6e9p3@Sftpb
5.08e-66FFCP PHASE2:Mm9::chr12:57630443..57630450,-#_67baccf18c7082ef5164dc24a9d7eafap4@E030019B13Rik
5.08e-66FFCP PHASE1:Mm9::chr12:57630443..57630450,-#_67baccf18c7082ef5164dc24a9d7eafap4@E030019B13Rik
4.92e-64FFCP PHASE1:Mm9::chr12:57623172..57623185,-#_7933a6201f3794ee85536fe649c0532ap@chr12:57623172..57623185, -
4.92e-64FFCP PHASE2:Mm9::chr14:70922007..70922052,+#_7933a6201f3794ee85536fe649c0532ap@chr14:70922007..70922052, +
4.92e-64FFCP PHASE2:Mm9::chr12:57623172..57623185,-#_7933a6201f3794ee85536fe649c0532ap@chr12:57623172..57623185, -
4.92e-64FFCP PHASE1:Mm9::chr14:70922007..70922052,+#_7933a6201f3794ee85536fe649c0532ap@chr14:70922007..70922052, +
5.59e-64FFCP PHASE2:Mm9::chr5:28785436..28785450,-#_345de06ed93652e7662302ba35fdb2ecp@chr5:28785436..28785450, -
5.59e-64FFCP PHASE1:Mm9::chr5:28785436..28785450,-#_345de06ed93652e7662302ba35fdb2ecp@chr5:28785436..28785450, -
6.35e-64FFCP PHASE1:Mm9::chr14:70922459..70922482,-#_c4555753bcb6cf24ffe0d903ba4ccb2ep@chr14:70922459..70922482, -
6.35e-64FFCP PHASE2:Mm9::chr14:70922459..70922482,-#_c4555753bcb6cf24ffe0d903ba4ccb2ep@chr14:70922459..70922482, -
2.55e-63FFCP PHASE2:Mm9::chr16:22439804..22439806,-#_b9e9cb28beb1e24c68a3f6ff3e34b735p4@Etv5
2.55e-63FFCP PHASE1:Mm9::chr16:22439804..22439806,-#_b9e9cb28beb1e24c68a3f6ff3e34b735p4@Etv5
1.43e-62FFCP PHASE1:Mm9::chr6:72259797..72259814,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72259797..72259814, +
1.43e-62FFCP PHASE2:Mm9::chr6:72259797..72259814,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72259797..72259814, +
1.43e-62FFCP PHASE2:Mm9::chr14:70922486..70922510,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr14:70922486..70922510, -
1.43e-62FFCP PHASE1:Mm9::chr6:72264890..72264911,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72264890..72264911, +
1.43e-62FFCP PHASE1:Mm9::chr12:57376690..57376716,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr12:57376690..57376716, -
1.43e-62FFCP PHASE2:Mm9::chr6:72264890..72264911,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72264890..72264911, +
1.43e-62FFCP PHASE1:Mm9::chr6:72263977..72263993,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72263977..72263993, +
1.43e-62FFCP PHASE2:Mm9::chr6:72264418..72264441,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72264418..72264441, +
1.43e-62FFCP PHASE1:Mm9::chr14:70923240..70923251,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr14:70923240..70923251, -
1.43e-62FFCP PHASE1:Mm9::chr6:72264418..72264441,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72264418..72264441, +
1.43e-62FFCP PHASE1:Mm9::chr16:19706386..19706390,-#_4743efbf66078b2a62e1e5ad24a3a4c0p4@Lamp3
1.43e-62FFCP PHASE1:Mm9::chr14:70922486..70922510,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr14:70922486..70922510, -
1.43e-62FFCP PHASE2:Mm9::chr16:19706386..19706390,-#_4743efbf66078b2a62e1e5ad24a3a4c0p4@Lamp3
1.43e-62FFCP PHASE2:Mm9::chr6:72263977..72263993,+#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr6:72263977..72263993, +
1.43e-62FFCP PHASE2:Mm9::chr12:57376690..57376716,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr12:57376690..57376716, -
1.43e-62FFCP PHASE2:Mm9::chr14:70923240..70923251,-#_4743efbf66078b2a62e1e5ad24a3a4c0p@chr14:70923240..70923251, -
1.63e-62FFCP PHASE1:Mm9::chr6:72264609..72264653,-#_af36b7cf71d497e01e8d9a4d381d5963p@chr6:72264609..72264653, -
1.63e-62FFCP PHASE2:Mm9::chr6:72264609..72264653,-#_af36b7cf71d497e01e8d9a4d381d5963p@chr6:72264609..72264653, -
1.87e-62FFCP PHASE1:Mm9::chr6:129378567..129378573,-#_f496c560db73a0374eccabe9a6f44525p@chr6:129378567..129378573, -
1.87e-62FFCP PHASE2:Mm9::chr6:129378567..129378573,-#_f496c560db73a0374eccabe9a6f44525p@chr6:129378567..129378573, -
1.91e-62FFCP PHASE2:Mm9::chr3:122432836..122432847,+#_3c249220c6d96947da7a80b212701bdcp16@Pde5a
1.91e-62FFCP PHASE1:Mm9::chr3:122432836..122432847,+#_3c249220c6d96947da7a80b212701bdcp16@Pde5a
3.02e-62FFCP PHASE1:Mm9::chr12:57637595..57637608,-#_bf0dd3b89dee6e7c35af37bb211e3688p7@Nkx2-1
3.02e-62FFCP PHASE2:Mm9::chr12:57637595..57637608,-#_bf0dd3b89dee6e7c35af37bb211e3688p7@Nkx2-1
5.06e-62FFCP PHASE1:Mm9::chr12:57636936..57636953,-#_f2282982ce082408699a2e7ffff3d411p@chr12:57636936..57636953, -
5.06e-62FFCP PHASE2:Mm9::chr12:57636936..57636953,-#_f2282982ce082408699a2e7ffff3d411p@chr12:57636936..57636953, -
7.58e-62FFCP PHASE1:Mm9::chr9:110959404..110959419,-#_d8b832e5201f56832e4fa4ec6435a795p9@Ccrl2
7.58e-62FFCP PHASE2:Mm9::chr16:19673260..19673277,-#_d8b832e5201f56832e4fa4ec6435a795p@chr16:19673260..19673277, -
7.58e-62FFCP PHASE1:Mm9::chr16:19673341..19673350,-#_d8b832e5201f56832e4fa4ec6435a795p@chr16:19673341..19673350, -
7.58e-62FFCP PHASE1:Mm9::chr9:14522825..14522837,-#_d8b832e5201f56832e4fa4ec6435a795p3@Piwil4
7.58e-62FFCP PHASE2:Mm9::chr12:57630433..57630438,-#_d8b832e5201f56832e4fa4ec6435a795p6@E030019B13Rik
7.58e-62FFCP PHASE2:Mm9::chr16:19673341..19673350,-#_d8b832e5201f56832e4fa4ec6435a795p@chr16:19673341..19673350, -
7.58e-62FFCP PHASE1:Mm9::chr17:67043399..67043410,-#_d8b832e5201f56832e4fa4ec6435a795p9@Ptprm
7.58e-62FFCP PHASE2:Mm9::chr14:41951096..41951112,+#_d8b832e5201f56832e4fa4ec6435a795p@chr14:41951096..41951112, +
7.58e-62FFCP PHASE1:Mm9::chr2:126950686..126950702,-#_d8b832e5201f56832e4fa4ec6435a795p@chr2:126950686..126950702, -
7.58e-62FFCP PHASE1:Mm9::chr6:72260761..72260774,-#_d8b832e5201f56832e4fa4ec6435a795p@chr6:72260761..72260774, -
7.58e-62FFCP PHASE2:Mm9::chr14:41949964..41949979,+#_d8b832e5201f56832e4fa4ec6435a795p@chr14:41949964..41949979, +
7.58e-62FFCP PHASE2:Mm9::chr5:28785382..28785394,-#_d8b832e5201f56832e4fa4ec6435a795p@chr5:28785382..28785394, -

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