MCL coexpression mm9:402
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0005524 | ATP binding | 0.00865956442285859 |
| GO:0032559 | adenyl ribonucleotide binding | 0.00865956442285859 |
| GO:0030554 | adenyl nucleotide binding | 0.00865956442285859 |
| GO:0032553 | ribonucleotide binding | 0.00865956442285859 |
| GO:0032555 | purine ribonucleotide binding | 0.00865956442285859 |
| GO:0017076 | purine nucleotide binding | 0.00865956442285859 |
| GO:0000166 | nucleotide binding | 0.0107813422052218 |
| GO:0004674 | protein serine/threonine kinase activity | 0.0141489964699634 |
| GO:0032982 | myosin filament | 0.0156774074596713 |
| GO:0005863 | striated muscle thick filament | 0.0156774074596713 |
| GO:0005859 | muscle myosin complex | 0.0156774074596713 |
| GO:0016460 | myosin II complex | 0.0162142769304795 |
| GO:0004672 | protein kinase activity | 0.0162142769304795 |
| GO:0006468 | protein amino acid phosphorylation | 0.0165141795883867 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.017971366889255 |
| GO:0016310 | phosphorylation | 0.017971366889255 |
| GO:0006941 | striated muscle contraction | 0.0200360524631142 |
| GO:0009791 | post-embryonic development | 0.0200360524631142 |
| GO:0006793 | phosphorus metabolic process | 0.0200360524631142 |
| GO:0006796 | phosphate metabolic process | 0.0200360524631142 |
| GO:0016301 | kinase activity | 0.0222815721268089 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 0.0277214315621512 |
| GO:0016459 | myosin complex | 0.0304552447940586 |
| GO:0030017 | sarcomere | 0.0337779570497254 |
| GO:0044449 | contractile fiber part | 0.0338952074532296 |
| GO:0030016 | myofibril | 0.0339509920293152 |
| GO:0043292 | contractile fiber | 0.0339509920293152 |
| GO:0043687 | post-translational protein modification | 0.0339509920293152 |
| GO:0003012 | muscle system process | 0.0339509920293152 |
| GO:0006936 | muscle contraction | 0.0339509920293152 |
| GO:0005516 | calmodulin binding | 0.0411566028369654 |
| GO:0006464 | protein modification process | 0.0411566028369654 |
| GO:0043412 | biopolymer modification | 0.0429372073283632 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| lung | 4.16e-20 | 14 |
| respiratory tube | 4.16e-20 | 14 |
| respiration organ | 4.16e-20 | 14 |
| pair of lungs | 4.16e-20 | 14 |
| lung primordium | 4.16e-20 | 14 |
| lung bud | 4.16e-20 | 14 |
| epithelial bud | 4.07e-16 | 17 |
| thoracic cavity element | 4.07e-16 | 17 |
| thoracic segment organ | 4.07e-16 | 17 |
| thoracic cavity | 4.07e-16 | 17 |
| thoracic segment of trunk | 4.07e-16 | 17 |
| respiratory primordium | 4.07e-16 | 17 |
| endoderm of foregut | 4.07e-16 | 17 |
| epithelial fold | 2.52e-13 | 20 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.000948649 |
| MA0004.1 | 0.527785 |
| MA0006.1 | 0.0769247 |
| MA0007.1 | 0.168178 |
| MA0009.1 | 0.535932 |
| MA0014.1 | 9.60776e-05 |
| MA0017.1 | 0.0906268 |
| MA0019.1 | 0.376509 |
| MA0024.1 | 0.496718 |
| MA0025.1 | 0.751694 |
| MA0027.1 | 2.14278 |
| MA0028.1 | 0.0821841 |
| MA0029.1 | 1.20119 |
| MA0030.1 | 2.1054 |
| MA0031.1 | 1.14633 |
| MA0038.1 | 0.285714 |
| MA0040.1 | 0.547233 |
| MA0041.1 | 0.129017 |
| MA0042.1 | 0.770017 |
| MA0043.1 | 0.624178 |
| MA0046.1 | 0.568473 |
| MA0048.1 | 0.295216 |
| MA0050.1 | 0.593445 |
| MA0051.1 | 0.2928 |
| MA0052.1 | 0.554531 |
| MA0055.1 | 0.19426 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0454221 |
| MA0058.1 | 0.751937 |
| MA0059.1 | 0.784716 |
| MA0060.1 | 0.0417645 |
| MA0061.1 | 0.766585 |
| MA0063.1 | 0 |
| MA0066.1 | 0.277072 |
| MA0067.1 | 0.857286 |
| MA0068.1 | 0.0481248 |
| MA0069.1 | 0.554839 |
| MA0070.1 | 0.54606 |
| MA0071.1 | 0.592012 |
| MA0072.1 | 0.538403 |
| MA0073.1 | 0.00024077 |
| MA0074.1 | 0.249359 |
| MA0076.1 | 0.101055 |
| MA0077.1 | 0.518913 |
| MA0078.1 | 0.319336 |
| MA0081.1 | 0.138626 |
| MA0083.1 | 0.623446 |
| MA0084.1 | 1.1752 |
| MA0087.1 | 0.583879 |
| MA0088.1 | 0.159731 |
| MA0089.1 | 0 |
| MA0090.1 | 2.8213 |
| MA0091.1 | 1.04884 |
| MA0092.1 | 0.918727 |
| MA0093.1 | 0.609251 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.2406 |
| MA0101.1 | 2.56607 |
| MA0103.1 | 0.657254 |
| MA0105.1 | 0.213264 |
| MA0106.1 | 0.325663 |
| MA0107.1 | 2.80635 |
| MA0108.2 | 0.395878 |
| MA0109.1 | 0 |
| MA0111.1 | 0.164756 |
| MA0113.1 | 0.818211 |
| MA0114.1 | 0.0527257 |
| MA0115.1 | 0.626759 |
| MA0116.1 | 0.265278 |
| MA0117.1 | 0.597086 |
| MA0119.1 | 0.130171 |
| MA0122.1 | 0.615314 |
| MA0124.1 | 0.80652 |
| MA0125.1 | 0.736412 |
| MA0130.1 | 0 |
| MA0131.1 | 0.372683 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.657882 |
| MA0136.1 | 0.731186 |
| MA0139.1 | 0.0308792 |
| MA0140.1 | 1.25438 |
| MA0141.1 | 0.10748 |
| MA0142.1 | 1.11899 |
| MA0143.1 | 0.31603 |
| MA0144.1 | 0.0540242 |
| MA0145.1 | 0.0816911 |
| MA0146.1 | 0.00163181 |
| MA0147.1 | 0.215066 |
| MA0148.1 | 2.36723 |
| MA0149.1 | 0.133214 |
| MA0062.2 | 0.0890335 |
| MA0035.2 | 0.244063 |
| MA0039.2 | 0.0241624 |
| MA0138.2 | 0.366012 |
| MA0002.2 | 0.886864 |
| MA0137.2 | 0.3443 |
| MA0104.2 | 0.145321 |
| MA0047.2 | 1.41968 |
| MA0112.2 | 0.0816855 |
| MA0065.2 | 0.027137 |
| MA0150.1 | 0.970484 |
| MA0151.1 | 0 |
| MA0152.1 | 0.285194 |
| MA0153.1 | 0.67335 |
| MA0154.1 | 0.0518625 |
| MA0155.1 | 0.034627 |
| MA0156.1 | 0.676622 |
| MA0157.1 | 1.05883 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0638985 |
| MA0160.1 | 0.560136 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0315479 |
| MA0163.1 | 0.0259833 |
| MA0164.1 | 0.73183 |
| MA0080.2 | 1.07311 |
| MA0018.2 | 0.272436 |
| MA0099.2 | 0.947425 |
| MA0079.2 | 0.00302608 |
| MA0102.2 | 1.22663 |
| MA0258.1 | 0.0472094 |
| MA0259.1 | 0.444163 |
| MA0442.1 | 0 |
