Novel motif:5

name:	motif5_CAGTGT

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

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GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

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GO ID	GO Term	p-value
GO:0050896	response to stimulus	1.814043e-63
GO:0007154	cell communication	4.636408e-38
GO:0051716	cellular response to stimulus	1.068107e-37
GO:0032501	multicellular organismal process	2.327455e-37
GO:0023052	signaling	5.923166e-36
GO:0007165	signal transduction	2.238033e-34
GO:0042221	response to chemical stimulus	1.295737e-31
GO:0006950	response to stress	1.252895e-29
GO:0002376	immune system process	3.548655e-29
GO:0065008	regulation of biological quality	3.150602e-28
GO:0065007	biological regulation	2.339961e-27
GO:0048731	system development	2.721959e-26
GO:0048583	regulation of response to stimulus	3.098974e-26
GO:0007275	multicellular organismal development	4.659915e-25
GO:0007166	cell surface receptor linked signaling pathway	9.399209e-25
GO:0050789	regulation of biological process	1.872122e-24
GO:0048856	anatomical structure development	9.220623e-24
GO:0032502	developmental process	1.234185e-23
GO:0048513	organ development	1.429874e-23
GO:0050794	regulation of cellular process	1.446890e-23
GO:0007599	hemostasis	3.512400e-23
GO:0007596	blood coagulation	3.897710e-22
GO:0048518	positive regulation of biological process	1.722087e-21
GO:0051179	localization	1.897332e-21
GO:0007155	cell adhesion	2.385915e-21
GO:0042060	wound healing	3.313101e-21
GO:0009611	response to wounding	6.008197e-21
GO:0050878	regulation of body fluid levels	2.055651e-20
GO:0001775	cell activation	4.085209e-20
GO:0006955	immune response	2.420162e-19
GO:0006952	defense response	3.845173e-19
GO:0032879	regulation of localization	5.407646e-19
GO:0016043	cellular component organization	4.566711e-18
GO:0071840	cellular component organization or biogenesis	1.464841e-17
GO:0048584	positive regulation of response to stimulus	2.117043e-17
GO:0050790	regulation of catalytic activity	3.298545e-17
GO:0051239	regulation of multicellular organismal process	4.652585e-17
GO:0023051	regulation of signaling	7.258577e-17
GO:0048522	positive regulation of cellular process	9.530013e-17
GO:0006810	transport	9.700152e-17
GO:0051234	establishment of localization	1.772869e-16
GO:0030334	regulation of cell migration	2.006072e-16
GO:0065009	regulation of molecular function	2.316307e-16
GO:0010646	regulation of cell communication	3.321814e-16
GO:0009607	response to biotic stimulus	4.611095e-16
GO:0040012	regulation of locomotion	5.092791e-16
GO:2000145	regulation of cell motility	2.468381e-15
GO:0009966	regulation of signal transduction	2.915379e-15
GO:0009617	response to bacterium	5.424221e-15
GO:0051707	response to other organism	7.226502e-15
GO:0051270	regulation of cellular component movement	1.178968e-14
GO:0002682	regulation of immune system process	1.836690e-14
GO:0010033	response to organic substance	2.391756e-14
GO:0050793	regulation of developmental process	3.431165e-14
GO:0040011	locomotion	4.148896e-14
GO:0030168	platelet activation	1.846905e-13
GO:0071842	cellular component organization at cellular level	3.556849e-13
GO:0032101	regulation of response to external stimulus	4.034108e-13
GO:0031399	regulation of protein modification process	4.360889e-13
GO:0044093	positive regulation of molecular function	4.751091e-13
GO:0051336	regulation of hydrolase activity	5.256532e-13
GO:0010647	positive regulation of cell communication	1.444091e-12
GO:0048870	cell motility	1.749874e-12
GO:0071841	cellular component organization or biogenesis at cellular level	2.579786e-12
GO:0051246	regulation of protein metabolic process	2.611725e-12
GO:0023056	positive regulation of signaling	2.816944e-12
GO:0030154	cell differentiation	2.991146e-12
GO:0010941	regulation of cell death	4.044076e-12
GO:0042981	regulation of apoptosis	4.411235e-12
GO:0043269	regulation of ion transport	4.641973e-12
GO:0009987	cellular process	5.522636e-12
GO:0070887	cellular response to chemical stimulus	6.247181e-12
GO:2000147	positive regulation of cell motility	6.812566e-12
GO:0030335	positive regulation of cell migration	6.913193e-12
GO:0040017	positive regulation of locomotion	1.113800e-11
GO:0043067	regulation of programmed cell death	1.324462e-11
GO:0032268	regulation of cellular protein metabolic process	1.325237e-11
GO:0002684	positive regulation of immune system process	1.413817e-11
GO:0043412	macromolecule modification	1.901581e-11
GO:0048869	cellular developmental process	2.127014e-11
GO:0019538	protein metabolic process	2.254894e-11
GO:0035556	intracellular signal transduction	2.785954e-11
GO:0006629	lipid metabolic process	2.847137e-11
GO:0050900	leukocyte migration	2.895600e-11
GO:0051272	positive regulation of cellular component movement	2.976039e-11
GO:0019220	regulation of phosphate metabolic process	3.028577e-11
GO:0010035	response to inorganic substance	3.051001e-11
GO:0006464	protein modification process	3.202731e-11
GO:0003008	system process	3.221357e-11
GO:0042325	regulation of phosphorylation	3.424411e-11
GO:0006915	apoptosis	3.682446e-11
GO:0002253	activation of immune response	3.802063e-11
GO:0016477	cell migration	4.265517e-11
GO:0012501	programmed cell death	6.188853e-11
GO:0001819	positive regulation of cytokine production	6.456944e-11
GO:0048519	negative regulation of biological process	7.568600e-11
GO:0006928	cellular component movement	8.099751e-11
GO:0001932	regulation of protein phosphorylation	9.016737e-11
GO:0051704	multi-organism process	9.363168e-11
GO:0043085	positive regulation of catalytic activity	1.369995e-10
GO:0051240	positive regulation of multicellular organismal process	1.439308e-10
GO:0010038	response to metal ion	1.598245e-10
GO:0050778	positive regulation of immune response	1.986707e-10
GO:0001817	regulation of cytokine production	2.241819e-10
GO:0051049	regulation of transport	2.903676e-10
GO:0002443	leukocyte mediated immunity	3.031260e-10
GO:0032496	response to lipopolysaccharide	3.157522e-10
GO:0002237	response to molecule of bacterial origin	3.508036e-10
GO:2000026	regulation of multicellular organismal development	3.609657e-10
GO:0043086	negative regulation of catalytic activity	4.090928e-10
GO:0045785	positive regulation of cell adhesion	4.138582e-10
GO:0006968	cellular defense response	6.538450e-10
GO:0006468	protein phosphorylation	6.563745e-10
GO:0034329	cell junction assembly	6.627682e-10
GO:0001816	cytokine production	8.373348e-10
GO:0044241	lipid digestion	9.595270e-10
GO:0009605	response to external stimulus	1.165260e-9
GO:0030007	cellular potassium ion homeostasis	1.180381e-9
GO:0042742	defense response to bacterium	1.375008e-9
GO:0006725	cellular aromatic compound metabolic process	1.504228e-9
GO:0006684	sphingomyelin metabolic process	1.511555e-9
GO:0009967	positive regulation of signal transduction	1.558992e-9
GO:0007186	G-protein coupled receptor protein signaling pathway	1.674484e-9
GO:0052547	regulation of peptidase activity	1.713954e-9
GO:0060415	muscle tissue morphogenesis	2.000818e-9
GO:0051592	response to calcium ion	2.362896e-9
GO:0030509	BMP signaling pathway	2.508656e-9
GO:0048660	regulation of smooth muscle cell proliferation	2.640267e-9
GO:0006796	phosphate-containing compound metabolic process	2.681721e-9
GO:0032680	regulation of tumor necrosis factor production	2.898950e-9
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	3.034203e-9
GO:0071844	cellular component assembly at cellular level	3.150467e-9
GO:0052548	regulation of endopeptidase activity	3.250166e-9
GO:0006958	complement activation, classical pathway	3.717974e-9
GO:0048523	negative regulation of cellular process	3.809948e-9
GO:0010743	regulation of macrophage derived foam cell differentiation	3.839277e-9
GO:0042592	homeostatic process	5.091208e-9
GO:0009894	regulation of catabolic process	5.415466e-9
GO:0032026	response to magnesium ion	6.155078e-9
GO:0055008	cardiac muscle tissue morphogenesis	6.361761e-9
GO:0010755	regulation of plasminogen activation	7.261046e-9
GO:0071466	cellular response to xenobiotic stimulus	7.278817e-9
GO:0050865	regulation of cell activation	7.764676e-9
GO:0044092	negative regulation of molecular function	7.933918e-9
GO:0051649	establishment of localization in cell	8.426187e-9
GO:0009410	response to xenobiotic stimulus	8.917894e-9
GO:0051222	positive regulation of protein transport	1.184235e-8
GO:0006875	cellular metal ion homeostasis	1.187608e-8
GO:0009888	tissue development	1.296479e-8
GO:0019932	second-messenger-mediated signaling	1.411042e-8
GO:0048585	negative regulation of response to stimulus	1.464172e-8
GO:0009653	anatomical structure morphogenesis	1.535696e-8
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	1.553119e-8
GO:0010466	negative regulation of peptidase activity	1.660989e-8
GO:0006954	inflammatory response	1.701443e-8
GO:0006686	sphingomyelin biosynthetic process	1.894178e-8
GO:0046903	secretion	1.961392e-8
GO:0010757	negative regulation of plasminogen activation	1.961814e-8
GO:0050727	regulation of inflammatory response	2.313907e-8
GO:0021683	cerebellar granular layer morphogenesis	2.415686e-8
GO:0007167	enzyme linked receptor protein signaling pathway	2.477756e-8
GO:0050776	regulation of immune response	2.540034e-8
GO:0060083	smooth muscle contraction involved in micturition	2.596809e-8
GO:0045321	leukocyte activation	3.162514e-8
GO:0048646	anatomical structure formation involved in morphogenesis	3.316057e-8
GO:0048514	blood vessel morphogenesis	3.346110e-8
GO:0045595	regulation of cell differentiation	3.424573e-8
GO:0051128	regulation of cellular component organization	3.572707e-8
GO:0032651	regulation of interleukin-1 beta production	3.664267e-8
GO:0034330	cell junction organization	3.746620e-8
GO:0006811	ion transport	4.162004e-8
GO:0090331	negative regulation of platelet aggregation	4.235024e-8
GO:0061110	dense core granule biogenesis	4.235024e-8
GO:0061108	seminal vesicle epithelium development	4.235024e-8
GO:0042628	mating plug formation	4.235024e-8
GO:0055065	metal ion homeostasis	4.336049e-8
GO:0009191	ribonucleoside diphosphate catabolic process	4.588974e-8
GO:0031581	hemidesmosome assembly	4.843788e-8
GO:0014067	negative regulation of phosphatidylinositol 3-kinase cascade	4.893870e-8
GO:0031589	cell-substrate adhesion	5.135525e-8
GO:0051050	positive regulation of transport	5.140321e-8
GO:0072358	cardiovascular system development	5.550745e-8
GO:0032844	regulation of homeostatic process	5.816238e-8
GO:0015872	dopamine transport	5.944000e-8
GO:0051248	negative regulation of protein metabolic process	6.024362e-8
GO:2000021	regulation of ion homeostasis	6.174932e-8
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	6.520547e-8
GO:0006805	xenobiotic metabolic process	6.664947e-8
GO:0030155	regulation of cell adhesion	7.133226e-8
GO:0009820	alkaloid metabolic process	7.164352e-8
GO:0045214	sarcomere organization	7.210597e-8
GO:0032103	positive regulation of response to external stimulus	7.466299e-8
GO:0044057	regulation of system process	7.659299e-8
GO:0006959	humoral immune response	8.055750e-8
GO:0042403	thyroid hormone metabolic process	8.056213e-8
GO:0044267	cellular protein metabolic process	8.234462e-8
GO:0034121	regulation of toll-like receptor signaling pathway	8.561163e-8
GO:0042127	regulation of cell proliferation	8.625445e-8
GO:0050729	positive regulation of inflammatory response	8.828004e-8
GO:0032652	regulation of interleukin-1 production	9.084026e-8
GO:0051094	positive regulation of developmental process	9.335386e-8
GO:0048662	negative regulation of smooth muscle cell proliferation	9.533642e-8
GO:0009449	gamma-aminobutyric acid biosynthetic process	1.005911e-7
GO:0030003	cellular cation homeostasis	1.014460e-7
GO:0051971	positive regulation of transmission of nerve impulse	1.041675e-7
GO:0045794	negative regulation of cell volume	1.079108e-7
GO:0048729	tissue morphogenesis	1.173312e-7
GO:0032989	cellular component morphogenesis	1.181722e-7
GO:0002757	immune response-activating signal transduction	1.196149e-7
GO:0044087	regulation of cellular component biogenesis	1.200077e-7
GO:0072376	protein activation cascade	1.281375e-7
GO:0019933	cAMP-mediated signaling	1.319055e-7
GO:0014832	urinary bladder smooth muscle contraction	1.340369e-7
GO:0046709	IDP catabolic process	1.424009e-7
GO:0046032	ADP catabolic process	1.424009e-7
GO:0045332	phospholipid translocation	1.516083e-7
GO:0031646	positive regulation of neurological system process	1.609925e-7
GO:0051769	regulation of nitric-oxide synthase biosynthetic process	1.626186e-7
GO:0010955	negative regulation of protein processing	1.650044e-7
GO:0051249	regulation of lymphocyte activation	1.693331e-7
GO:0009268	response to pH	1.725712e-7
GO:0002455	humoral immune response mediated by circulating immunoglobulin	1.742745e-7
GO:0042493	response to drug	1.791035e-7
GO:0002694	regulation of leukocyte activation	1.849438e-7
GO:0016310	phosphorylation	1.935849e-7
GO:0050877	neurological system process	1.960429e-7
GO:2000116	regulation of cysteine-type endopeptidase activity	1.962934e-7
GO:0006935	chemotaxis	1.991874e-7
GO:0032836	glomerular basement membrane development	2.014927e-7
GO:0051641	cellular localization	2.109581e-7
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	2.326032e-7
GO:0009181	purine ribonucleoside diphosphate catabolic process	2.379203e-7
GO:0007602	phototransduction	2.394011e-7
GO:0048732	gland development	2.420792e-7
GO:0070373	negative regulation of ERK1 and ERK2 cascade	2.459639e-7
GO:0071310	cellular response to organic substance	2.476720e-7
GO:0051131	chaperone-mediated protein complex assembly	2.478175e-7
GO:0009581	detection of external stimulus	2.490687e-7
GO:0006644	phospholipid metabolic process	2.504548e-7
GO:0046486	glycerolipid metabolic process	2.514586e-7
GO:0021696	cerebellar cortex morphogenesis	2.613757e-7
GO:0007250	activation of NF-kappaB-inducing kinase activity	2.642398e-7
GO:0044255	cellular lipid metabolic process	2.646349e-7
GO:0032940	secretion by cell	2.696842e-7
GO:0030299	intestinal cholesterol absorption	2.841653e-7
GO:0022607	cellular component assembly	3.248227e-7
GO:0061041	regulation of wound healing	3.262156e-7
GO:0002520	immune system development	3.454926e-7
GO:0043065	positive regulation of apoptosis	3.547679e-7
GO:0008219	cell death	3.593606e-7
GO:0051960	regulation of nervous system development	3.707400e-7
GO:0050867	positive regulation of cell activation	3.716660e-7
GO:0006769	nicotinamide metabolic process	3.948162e-7
GO:0009435	NAD biosynthetic process	3.963690e-7
GO:0030036	actin cytoskeleton organization	3.990110e-7
GO:0051338	regulation of transferase activity	4.144899e-7
GO:0070482	response to oxygen levels	4.361810e-7
GO:0071216	cellular response to biotic stimulus	4.534823e-7
GO:0032731	positive regulation of interleukin-1 beta production	4.554287e-7
GO:0055080	cation homeostasis	4.699146e-7
GO:0050663	cytokine secretion	4.704932e-7
GO:0033363	secretory granule organization	4.750862e-7
GO:0002449	lymphocyte mediated immunity	4.869792e-7
GO:0050806	positive regulation of synaptic transmission	4.913233e-7
GO:0019222	regulation of metabolic process	4.948890e-7
GO:0002764	immune response-regulating signaling pathway	5.257975e-7
GO:0050801	ion homeostasis	5.317247e-7
GO:0050851	antigen receptor-mediated signaling pathway	5.318077e-7
GO:0006873	cellular ion homeostasis	5.400454e-7
GO:0071219	cellular response to molecule of bacterial origin	5.553036e-7
GO:0051345	positive regulation of hydrolase activity	5.620933e-7
GO:0007015	actin filament organization	5.773705e-7
GO:0071345	cellular response to cytokine stimulus	6.001285e-7
GO:0010942	positive regulation of cell death	6.346250e-7
GO:0034465	response to carbon monoxide	6.607534e-7
GO:0007417	central nervous system development	6.759914e-7
GO:0060073	micturition	7.372635e-7
GO:0071222	cellular response to lipopolysaccharide	7.515907e-7
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	7.530449e-7
GO:0007160	cell-matrix adhesion	7.654062e-7
GO:0006140	regulation of nucleotide metabolic process	8.286370e-7
GO:0002252	immune effector process	8.427128e-7
GO:0019359	nicotinamide nucleotide biosynthetic process	8.443420e-7
GO:0007267	cell-cell signaling	8.460111e-7
GO:0016265	death	9.008119e-7
GO:0051346	negative regulation of hydrolase activity	9.040272e-7
GO:0010959	regulation of metal ion transport	9.092591e-7
GO:0043068	positive regulation of programmed cell death	9.148586e-7
GO:0048644	muscle organ morphogenesis	9.463452e-7
GO:0071805	potassium ion transmembrane transport	9.590327e-7
GO:0008610	lipid biosynthetic process	1.023573e-6
GO:0008037	cell recognition	1.040816e-6
GO:0051606	detection of stimulus	1.053290e-6
GO:0009719	response to endogenous stimulus	1.110064e-6
GO:0030595	leukocyte chemotaxis	1.113575e-6
GO:0042446	hormone biosynthetic process	1.117662e-6
GO:0007399	nervous system development	1.166112e-6
GO:0040018	positive regulation of multicellular organism growth	1.214213e-6
GO:0044085	cellular component biogenesis	1.256626e-6
GO:0009306	protein secretion	1.270368e-6
GO:0070972	protein localization in endoplasmic reticulum	1.343722e-6
GO:0007243	intracellular protein kinase cascade	1.352168e-6
GO:0007600	sensory perception	1.354031e-6
GO:0032509	endosome transport via multivesicular body sorting pathway	1.379024e-6
GO:0019221	cytokine-mediated signaling pathway	1.382170e-6
GO:0032655	regulation of interleukin-12 production	1.387799e-6
GO:0071954	chemokine (C-C motif) ligand 11 production	1.410996e-6
GO:0035712	T-helper 2 cell activation	1.410996e-6
GO:2000525	positive regulation of T cell costimulation	1.410996e-6
GO:0002215	defense response to nematode	1.410996e-6
GO:0035708	interleukin-4-dependent isotype switching to IgE isotypes	1.410996e-6
GO:0035709	memory T cell activation	1.410996e-6
GO:0033160	positive regulation of protein import into nucleus, translocation	1.419742e-6
GO:0043549	regulation of kinase activity	1.454514e-6
GO:0090361	regulation of platelet-derived growth factor production	1.512789e-6
GO:0019935	cyclic-nucleotide-mediated signaling	1.556755e-6
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	1.613886e-6
GO:0010883	regulation of lipid storage	1.660522e-6
GO:0071360	cellular response to exogenous dsRNA	1.666011e-6
GO:0006228	UTP biosynthetic process	1.666011e-6
GO:0006183	GTP biosynthetic process	1.666011e-6
GO:0006165	nucleoside diphosphate phosphorylation	1.666011e-6
GO:0043687	post-translational protein modification	1.684671e-6
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	1.692984e-6
GO:0032431	activation of phospholipase A2 activity	1.696096e-6
GO:0002832	negative regulation of response to biotic stimulus	1.698652e-6
GO:0042113	B cell activation	1.699628e-6
GO:0032675	regulation of interleukin-6 production	1.712848e-6
GO:0032732	positive regulation of interleukin-1 production	1.742157e-6
GO:0035587	purinergic receptor signaling pathway	1.754506e-6
GO:0032430	positive regulation of phospholipase A2 activity	1.951484e-6
GO:0010627	regulation of intracellular protein kinase cascade	1.995084e-6
GO:0002429	immune response-activating cell surface receptor signaling pathway	2.005860e-6
GO:0030029	actin filament-based process	2.119163e-6
GO:0019725	cellular homeostasis	2.204166e-6
GO:0009615	response to virus	2.208478e-6
GO:0015698	inorganic anion transport	2.212968e-6
GO:0001525	angiogenesis	2.241031e-6
GO:0010888	negative regulation of lipid storage	2.265446e-6
GO:0060326	cell chemotaxis	2.267910e-6
GO:0007044	cell-substrate junction assembly	2.323987e-6
GO:0023057	negative regulation of signaling	2.379864e-6
GO:0050853	B cell receptor signaling pathway	2.439444e-6
GO:0070874	negative regulation of glycogen metabolic process	2.541414e-6
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	2.609078e-6
GO:0002696	positive regulation of leukocyte activation	2.639682e-6
GO:0009628	response to abiotic stimulus	2.713888e-6
GO:0021983	pituitary gland development	2.813698e-6
GO:0006144	purine base metabolic process	2.830346e-6
GO:0051969	regulation of transmission of nerve impulse	2.909207e-6
GO:0060537	muscle tissue development	2.919727e-6
GO:0070613	regulation of protein processing	2.924019e-6
GO:0032269	negative regulation of cellular protein metabolic process	3.053717e-6
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	3.059861e-6
GO:0032252	secretory granule localization	3.061555e-6
GO:0010740	positive regulation of intracellular protein kinase cascade	3.088557e-6
GO:0042537	benzene-containing compound metabolic process	3.105830e-6
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	3.106250e-6
GO:0048609	multicellular organismal reproductive process	3.177947e-6
GO:0010811	positive regulation of cell-substrate adhesion	3.285481e-6
GO:0010648	negative regulation of cell communication	3.297789e-6
GO:0031057	negative regulation of histone modification	3.390165e-6
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	3.401545e-6
GO:0010766	negative regulation of sodium ion transport	3.776563e-6
GO:0060795	cell fate commitment involved in formation of primary germ layers	3.801751e-6
GO:0050920	regulation of chemotaxis	3.892691e-6
GO:0051093	negative regulation of developmental process	3.914701e-6
GO:0019674	NAD metabolic process	4.064603e-6
GO:0090116	C-5 methylation of cytosine	4.229023e-6
GO:0006879	cellular iron ion homeostasis	4.350823e-6
GO:0045087	innate immune response	4.398832e-6
GO:0042789	mRNA transcription from RNA polymerase II promoter	4.462788e-6
GO:0009156	ribonucleoside monophosphate biosynthetic process	4.465187e-6
GO:0007194	negative regulation of adenylate cyclase activity	4.658238e-6
GO:0019724	B cell mediated immunity	4.859934e-6
GO:0001568	blood vessel development	4.904714e-6
GO:0030814	regulation of cAMP metabolic process	4.948433e-6
GO:0046498	S-adenosylhomocysteine metabolic process	4.950659e-6
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	5.005526e-6
GO:0006956	complement activation	5.252475e-6
GO:0032776	DNA methylation on cytosine	5.396157e-6
GO:0032735	positive regulation of interleukin-12 production	5.441388e-6
GO:0010869	regulation of receptor biosynthetic process	5.508814e-6
GO:0030097	hemopoiesis	5.529709e-6
GO:0033993	response to lipid	5.621464e-6
GO:0048878	chemical homeostasis	5.653298e-6
GO:0045165	cell fate commitment	5.671487e-6
GO:0031400	negative regulation of protein modification process	5.861566e-6
GO:0016064	immunoglobulin mediated immune response	6.187167e-6
GO:0048738	cardiac muscle tissue development	6.188953e-6
GO:0043502	regulation of muscle adaptation	6.313662e-6
GO:0003013	circulatory system process	6.361678e-6
GO:0046131	pyrimidine ribonucleoside metabolic process	6.374145e-6
GO:0048468	cell development	6.412135e-6
GO:0018958	phenol-containing compound metabolic process	6.526155e-6
GO:0030183	B cell differentiation	6.552528e-6
GO:0046467	membrane lipid biosynthetic process	6.653898e-6
GO:0006590	thyroid hormone generation	6.660907e-6
GO:0045666	positive regulation of neuron differentiation	7.148182e-6
GO:0040007	growth	7.190945e-6
GO:0043154	negative regulation of caspase activity	7.273177e-6
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	7.375919e-6
GO:0040013	negative regulation of locomotion	7.382718e-6
GO:0051350	negative regulation of lyase activity	7.543054e-6
GO:0030035	microspike assembly	7.833049e-6
GO:0000902	cell morphogenesis	7.978897e-6
GO:0007420	brain development	8.072887e-6
GO:0043434	response to peptide hormone stimulus	8.179948e-6
GO:0048009	insulin-like growth factor receptor signaling pathway	8.217153e-6
GO:0007517	muscle organ development	8.232226e-6
GO:0002768	immune response-regulating cell surface receptor signaling pathway	8.366819e-6
GO:0090291	negative regulation of osteoclast proliferation	8.555318e-6
GO:2000347	positive regulation of hepatocyte proliferation	8.555318e-6
GO:0072573	tolerance induction to lipopolysaccharide	8.555318e-6
GO:2000349	negative regulation of CD40 signaling pathway	8.555318e-6
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	8.555318e-6
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	8.555318e-6
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	8.555318e-6
GO:0048534	hemopoietic or lymphoid organ development	8.746138e-6
GO:0055010	ventricular cardiac muscle tissue morphogenesis	8.836307e-6
GO:0030817	regulation of cAMP biosynthetic process	8.987423e-6
GO:0031644	regulation of neurological system process	9.450781e-6
GO:0014848	urinary tract smooth muscle contraction	9.535323e-6
GO:0035270	endocrine system development	9.606140e-6
GO:0009167	purine ribonucleoside monophosphate metabolic process	9.965164e-6
GO:0021854	hypothalamus development	1.005388e-5
GO:0009968	negative regulation of signal transduction	1.009531e-5
GO:0021681	cerebellar granular layer development	1.053103e-5
GO:0019226	transmission of nerve impulse	1.067140e-5
GO:0045859	regulation of protein kinase activity	1.106887e-5
GO:0045637	regulation of myeloid cell differentiation	1.118155e-5
GO:0050869	negative regulation of B cell activation	1.138495e-5
GO:0006241	CTP biosynthetic process	1.181882e-5
GO:0080134	regulation of response to stress	1.191716e-5
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	1.203598e-5
GO:0032463	negative regulation of protein homooligomerization	1.208408e-5
GO:0001944	vasculature development	1.228761e-5
GO:0009112	nucleobase metabolic process	1.239274e-5
GO:0003229	ventricular cardiac muscle tissue development	1.247879e-5
GO:0045719	negative regulation of glycogen biosynthetic process	1.303064e-5
GO:0007268	synaptic transmission	1.310882e-5
GO:0045596	negative regulation of cell differentiation	1.344256e-5
GO:0010745	negative regulation of macrophage derived foam cell differentiation	1.378997e-5
GO:0060600	dichotomous subdivision of an epithelial terminal unit	1.384685e-5
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1.418056e-5
GO:0055082	cellular chemical homeostasis	1.422182e-5
GO:0044238	primary metabolic process	1.428230e-5
GO:0010810	regulation of cell-substrate adhesion	1.449476e-5
GO:0045124	regulation of bone resorption	1.452716e-5
GO:0019637	organophosphate metabolic process	1.456980e-5
GO:0040008	regulation of growth	1.492793e-5
GO:0035590	purinergic nucleotide receptor signaling pathway	1.501480e-5
GO:0006704	glucocorticoid biosynthetic process	1.545331e-5
GO:0046847	filopodium assembly	1.545558e-5
GO:0045056	transcytosis	1.547332e-5
GO:0010614	negative regulation of cardiac muscle hypertrophy	1.592659e-5
GO:0009161	ribonucleoside monophosphate metabolic process	1.604337e-5
GO:0008015	blood circulation	1.613153e-5
GO:0051937	catecholamine transport	1.639569e-5
GO:0051241	negative regulation of multicellular organismal process	1.744657e-5
GO:0071634	regulation of transforming growth factor beta production	1.771572e-5
GO:0055015	ventricular cardiac muscle cell development	1.797044e-5
GO:0007588	excretion	1.863804e-5
GO:0016192	vesicle-mediated transport	1.869037e-5
GO:0010524	positive regulation of calcium ion transport into cytosol	1.901545e-5
GO:0016044	cellular membrane organization	1.959990e-5
GO:0051788	response to misfolded protein	1.962144e-5
GO:0032755	positive regulation of interleukin-6 production	1.967508e-5
GO:0046649	lymphocyte activation	1.976044e-5
GO:0006812	cation transport	1.984311e-5
GO:0009880	embryonic pattern specification	1.987544e-5
GO:0032102	negative regulation of response to external stimulus	2.024714e-5
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	2.034916e-5
GO:0034762	regulation of transmembrane transport	2.120271e-5
GO:0030030	cell projection organization	2.130299e-5
GO:0055009	atrial cardiac muscle tissue morphogenesis	2.170914e-5
GO:0031032	actomyosin structure organization	2.201941e-5
GO:0000904	cell morphogenesis involved in differentiation	2.244829e-5
GO:0080090	regulation of primary metabolic process	2.253334e-5
GO:0030239	myofibril assembly	2.265797e-5
GO:0034123	positive regulation of toll-like receptor signaling pathway	2.293067e-5
GO:0001666	response to hypoxia	2.446887e-5
GO:0061024	membrane organization	2.460859e-5
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	2.529476e-5
GO:0045765	regulation of angiogenesis	2.540070e-5
GO:0002446	neutrophil mediated immunity	2.650284e-5
GO:0010677	negative regulation of cellular carbohydrate metabolic process	2.695011e-5
GO:0014706	striated muscle tissue development	2.894171e-5
GO:0050852	T cell receptor signaling pathway	2.922231e-5
GO:0050864	regulation of B cell activation	2.955007e-5
GO:0097035	regulation of membrane lipid distribution	2.964128e-5
GO:0048596	embryonic camera-type eye morphogenesis	2.967838e-5
GO:0009582	detection of abiotic stimulus	2.971276e-5
GO:0007162	negative regulation of cell adhesion	2.995066e-5
GO:0000165	MAPKKK cascade	3.144456e-5
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	3.197442e-5
GO:0009896	positive regulation of catabolic process	3.212515e-5
GO:0060402	calcium ion transport into cytosol	3.258147e-5
GO:0033121	regulation of purine nucleotide catabolic process	3.270153e-5
GO:0050771	negative regulation of axonogenesis	3.297066e-5

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0006952	defense response	2.421913e-22
GO:0050896	response to stimulus	4.041977e-17
GO:0006953	acute-phase response	4.818643e-17
GO:0006954	inflammatory response	5.478882e-17
GO:0030488	tRNA methylation	7.492852e-17
GO:0002526	acute inflammatory response	3.557300e-16
GO:0002376	immune system process	4.646896e-15
GO:0031347	regulation of defense response	2.137543e-14
GO:0050727	regulation of inflammatory response	3.989350e-13
GO:0006810	transport	5.476544e-13
GO:0051234	establishment of localization	8.971222e-13
GO:0032101	regulation of response to external stimulus	2.106576e-12
GO:0009611	response to wounding	3.045614e-12
GO:0002684	positive regulation of immune system process	5.918266e-12
GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis	7.102654e-12
GO:0030502	negative regulation of bone mineralization	1.239297e-11
GO:0030157	pancreatic juice secretion	1.722668e-11
GO:0001817	regulation of cytokine production	1.876661e-11
GO:0045780	positive regulation of bone resorption	2.010632e-11
GO:0021987	cerebral cortex development	2.850901e-11
GO:0070168	negative regulation of biomineral tissue development	3.039814e-11
GO:0051179	localization	3.481377e-11
GO:0006950	response to stress	6.198257e-11
GO:0046466	membrane lipid catabolic process	7.091018e-11
GO:0034097	response to cytokine stimulus	7.156340e-11
GO:0042221	response to chemical stimulus	7.648311e-11
GO:0030149	sphingolipid catabolic process	8.760356e-11
GO:0045124	regulation of bone resorption	1.200740e-10
GO:0046627	negative regulation of insulin receptor signaling pathway	1.335561e-10
GO:0009617	response to bacterium	1.685766e-10
GO:0016192	vesicle-mediated transport	1.993061e-10
GO:0071345	cellular response to cytokine stimulus	3.089335e-10
GO:0044242	cellular lipid catabolic process	3.434642e-10
GO:0002682	regulation of immune system process	4.013654e-10
GO:0045807	positive regulation of endocytosis	4.662456e-10
GO:0008033	tRNA processing	7.139225e-10
GO:0032846	positive regulation of homeostatic process	1.211684e-9
GO:0006507	GPI anchor release	1.423442e-9
GO:0050766	positive regulation of phagocytosis	2.826442e-9
GO:0042742	defense response to bacterium	3.775688e-9
GO:0046850	regulation of bone remodeling	5.655093e-9
GO:0007050	cell cycle arrest	7.167826e-9
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	7.371268e-9
GO:0009607	response to biotic stimulus	7.384314e-9
GO:0001819	positive regulation of cytokine production	7.878907e-9
GO:0034105	positive regulation of tissue remodeling	1.252977e-8
GO:0006400	tRNA modification	1.544006e-8
GO:0051249	regulation of lymphocyte activation	1.742319e-8
GO:0042269	regulation of natural killer cell mediated cytotoxicity	1.868252e-8
GO:0065008	regulation of biological quality	1.899858e-8
GO:0044281	small molecule metabolic process	1.954736e-8
GO:0051707	response to other organism	2.041075e-8
GO:0080134	regulation of response to stress	2.063406e-8
GO:0050776	regulation of immune response	2.292193e-8
GO:0032501	multicellular organismal process	2.321767e-8
GO:0034391	regulation of smooth muscle cell apoptosis	3.923975e-8
GO:0006955	immune response	3.967808e-8
GO:0006399	tRNA metabolic process	5.247929e-8
GO:0060509	Type I pneumocyte differentiation	5.605307e-8
GO:0051704	multi-organism process	6.345552e-8
GO:0050863	regulation of T cell activation	7.062818e-8
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	7.230121e-8
GO:0006110	regulation of glycolysis	8.275198e-8
GO:0040011	locomotion	8.888130e-8
GO:0046514	ceramide catabolic process	1.118363e-7
GO:0010743	regulation of macrophage derived foam cell differentiation	1.318025e-7
GO:0051050	positive regulation of transport	1.634370e-7
GO:0032663	regulation of interleukin-2 production	1.897050e-7
GO:0046626	regulation of insulin receptor signaling pathway	2.070675e-7
GO:0002694	regulation of leukocyte activation	2.338950e-7
GO:0051240	positive regulation of multicellular organismal process	2.398980e-7
GO:0030001	metal ion transport	2.749317e-7
GO:0035630	bone mineralization involved in bone maturation	2.857029e-7
GO:0045088	regulation of innate immune response	2.930223e-7
GO:0050764	regulation of phagocytosis	2.965231e-7
GO:0044341	sodium-dependent phosphate transport	3.406175e-7
GO:0048583	regulation of response to stimulus	3.493964e-7
GO:0006811	ion transport	3.526615e-7
GO:0045786	negative regulation of cell cycle	3.622381e-7
GO:0050865	regulation of cell activation	3.784971e-7
GO:0006812	cation transport	3.816778e-7
GO:0032102	negative regulation of response to external stimulus	4.031662e-7
GO:0048193	Golgi vesicle transport	4.771281e-7
GO:0050778	positive regulation of immune response	4.843118e-7
GO:0051716	cellular response to stimulus	6.183591e-7
GO:0034103	regulation of tissue remodeling	6.878240e-7
GO:0097035	regulation of membrane lipid distribution	6.887204e-7
GO:0010906	regulation of glucose metabolic process	7.324276e-7
GO:0008045	motor axon guidance	7.959000e-7
GO:0019752	carboxylic acid metabolic process	8.068602e-7
GO:0010827	regulation of glucose transport	8.488246e-7
GO:0043931	ossification involved in bone maturation	9.376300e-7
GO:0014834	satellite cell maintenance involved in skeletal muscle regeneration	9.727143e-7
GO:0060510	Type II pneumocyte differentiation	9.946467e-7
GO:0006518	peptide metabolic process	9.954705e-7
GO:0009056	catabolic process	1.069135e-6
GO:0016042	lipid catabolic process	1.135352e-6
GO:0001887	selenium compound metabolic process	1.239304e-6
GO:0014706	striated muscle tissue development	1.241562e-6
GO:0010575	positive regulation vascular endothelial growth factor production	1.247954e-6
GO:0048513	organ development	1.254989e-6
GO:0046903	secretion	1.282181e-6
GO:0006082	organic acid metabolic process	1.291651e-6
GO:0042180	cellular ketone metabolic process	1.438855e-6
GO:0021543	pallium development	1.460334e-6
GO:0045329	carnitine biosynthetic process	1.634052e-6
GO:0048660	regulation of smooth muscle cell proliferation	1.804492e-6
GO:0009791	post-embryonic development	1.847059e-6
GO:0000003	reproduction	1.857321e-6
GO:0006749	glutathione metabolic process	1.923656e-6
GO:0070977	bone maturation	1.941054e-6
GO:0009451	RNA modification	2.022508e-6
GO:0050870	positive regulation of T cell activation	2.035655e-6
GO:0021960	anterior commissure morphogenesis	2.038453e-6
GO:0031349	positive regulation of defense response	2.070181e-6
GO:0010033	response to organic substance	2.254588e-6
GO:0006678	glucosylceramide metabolic process	2.284004e-6
GO:0007186	G-protein coupled receptor protein signaling pathway	2.374167e-6
GO:0031348	negative regulation of defense response	2.391955e-6
GO:0030154	cell differentiation	2.504915e-6
GO:0014904	myotube cell development	2.576338e-6
GO:0060537	muscle tissue development	2.588180e-6
GO:0002706	regulation of lymphocyte mediated immunity	2.667902e-6
GO:0042592	homeostatic process	2.732779e-6
GO:0032844	regulation of homeostatic process	2.735369e-6
GO:0006813	potassium ion transport	2.864949e-6
GO:0021799	cerebral cortex radially oriented cell migration	2.963539e-6
GO:0007010	cytoskeleton organization	2.997863e-6
GO:0050901	leukocyte tethering or rolling	3.038597e-6
GO:0048585	negative regulation of response to stimulus	3.300951e-6
GO:0001910	regulation of leukocyte mediated cytotoxicity	3.313007e-6
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	3.369525e-6
GO:0010269	response to selenium ion	3.626165e-6
GO:0055114	oxidation-reduction process	4.077208e-6
GO:0019722	calcium-mediated signaling	4.186519e-6
GO:0031341	regulation of cell killing	4.400456e-6
GO:0010744	positive regulation of macrophage derived foam cell differentiation	4.940850e-6
GO:0006968	cellular defense response	5.075743e-6
GO:0048240	sperm capacitation	5.227123e-6
GO:0046324	regulation of glucose import	5.309397e-6
GO:0044248	cellular catabolic process	5.381994e-6
GO:0007165	signal transduction	5.482316e-6
GO:0048869	cellular developmental process	5.521199e-6
GO:0045089	positive regulation of innate immune response	5.621166e-6
GO:0051649	establishment of localization in cell	6.035406e-6
GO:0065007	biological regulation	6.208586e-6
GO:0051251	positive regulation of lymphocyte activation	6.651546e-6
GO:0051241	negative regulation of multicellular organismal process	6.913873e-6
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	6.952114e-6
GO:0009605	response to external stimulus	7.582009e-6
GO:0014894	response to denervation involved in regulation of muscle adaptation	7.739251e-6
GO:0070587	regulation of cell-cell adhesion involved in gastrulation	8.384767e-6
GO:0034114	regulation of heterotypic cell-cell adhesion	8.384767e-6
GO:0016074	snoRNA metabolic process	8.423291e-6
GO:0034383	low-density lipoprotein particle clearance	8.918775e-6
GO:0032649	regulation of interferon-gamma production	8.951417e-6
GO:0030029	actin filament-based process	9.063085e-6
GO:0002673	regulation of acute inflammatory response	9.333556e-6
GO:0046032	ADP catabolic process	9.477534e-6
GO:0046709	IDP catabolic process	9.477534e-6
GO:0044282	small molecule catabolic process	9.507120e-6
GO:0072329	monocarboxylic acid catabolic process	9.522490e-6
GO:0009750	response to fructose stimulus	9.772235e-6
GO:0032879	regulation of localization	9.883701e-6
GO:0032655	regulation of interleukin-12 production	1.014317e-5
GO:0022414	reproductive process	1.108890e-5
GO:0021537	telencephalon development	1.111955e-5
GO:0044255	cellular lipid metabolic process	1.166564e-5
GO:0009062	fatty acid catabolic process	1.216160e-5
GO:0010675	regulation of cellular carbohydrate metabolic process	1.222096e-5
GO:0045076	regulation of interleukin-2 biosynthetic process	1.266403e-5
GO:0001660	fever generation	1.270547e-5
GO:0033152	immunoglobulin V(D)J recombination	1.283381e-5
GO:0032502	developmental process	1.292872e-5
GO:0048305	immunoglobulin secretion	1.383693e-5
GO:0003006	developmental process involved in reproduction	1.403979e-5
GO:0006629	lipid metabolic process	1.410842e-5
GO:0007154	cell communication	1.438954e-5
GO:0034392	negative regulation of smooth muscle cell apoptosis	1.449326e-5
GO:0010574	regulation of vascular endothelial growth factor production	1.539160e-5
GO:0031032	actomyosin structure organization	1.539709e-5
GO:0060741	prostate gland stromal morphogenesis	1.545878e-5
GO:0000212	meiotic spindle organization	1.545878e-5
GO:0007565	female pregnancy	1.555734e-5
GO:0006109	regulation of carbohydrate metabolic process	1.580654e-5
GO:0006725	cellular aromatic compound metabolic process	1.596919e-5
GO:0050867	positive regulation of cell activation	1.662327e-5
GO:0032729	positive regulation of interferon-gamma production	1.664733e-5
GO:0048009	insulin-like growth factor receptor signaling pathway	1.736664e-5
GO:0048518	positive regulation of biological process	1.783276e-5
GO:0045907	positive regulation of vasoconstriction	2.105456e-5
GO:0009306	protein secretion	2.116235e-5
GO:0046425	regulation of JAK-STAT cascade	2.127986e-5
GO:0000038	very long-chain fatty acid metabolic process	2.142196e-5
GO:0002237	response to molecule of bacterial origin	2.217632e-5
GO:0032940	secretion by cell	2.233622e-5
GO:0008203	cholesterol metabolic process	2.236089e-5
GO:0023052	signaling	2.303387e-5
GO:0010886	positive regulation of cholesterol storage	2.327291e-5
GO:0051239	regulation of multicellular organismal process	2.393622e-5
GO:0030036	actin cytoskeleton organization	2.424187e-5
GO:0030100	regulation of endocytosis	2.441027e-5
GO:0030239	myofibril assembly	2.613211e-5
GO:0001818	negative regulation of cytokine production	2.715280e-5
GO:0046395	carboxylic acid catabolic process	2.797484e-5
GO:0050810	regulation of steroid biosynthetic process	2.839402e-5
GO:0042953	lipoprotein transport	2.846807e-5
GO:0043043	peptide biosynthetic process	2.863584e-5
GO:0050830	defense response to Gram-positive bacterium	2.896488e-5
GO:0010828	positive regulation of glucose transport	2.902907e-5
GO:0034766	negative regulation of ion transmembrane transport	2.988134e-5
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	2.988134e-5
GO:0021758	putamen development	2.988134e-5
GO:0021757	caudate nucleus development	2.988134e-5
GO:0017121	phospholipid scrambling	2.988134e-5
GO:0021615	glossopharyngeal nerve morphogenesis	2.988134e-5
GO:0042035	regulation of cytokine biosynthetic process	3.081201e-5
GO:0007166	cell surface receptor linked signaling pathway	3.188020e-5
GO:0006787	porphyrin-containing compound catabolic process	3.448410e-5
GO:0006928	cellular component movement	3.457987e-5
GO:0006707	cholesterol catabolic process	3.480925e-5
GO:0002703	regulation of leukocyte mediated immunity	3.563380e-5
GO:0030900	forebrain development	3.605248e-5
GO:0043467	regulation of generation of precursor metabolites and energy	3.619836e-5
GO:0002696	positive regulation of leukocyte activation	3.685693e-5
GO:0030279	negative regulation of ossification	3.885604e-5
GO:0010464	regulation of mesenchymal cell proliferation	4.074130e-5
GO:0032496	response to lipopolysaccharide	4.397541e-5
GO:0006089	lactate metabolic process	4.453833e-5
GO:0045086	positive regulation of interleukin-2 biosynthetic process	4.459483e-5
GO:0070887	cellular response to chemical stimulus	4.530549e-5
GO:0048584	positive regulation of response to stimulus	4.574235e-5
GO:0048662	negative regulation of smooth muscle cell proliferation	4.579248e-5
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	4.694681e-5
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	4.767520e-5
GO:0016044	cellular membrane organization	4.811857e-5
GO:0006892	post-Golgi vesicle-mediated transport	4.951370e-5
GO:0032787	monocarboxylic acid metabolic process	5.166087e-5
GO:0016554	cytidine to uridine editing	5.244725e-5
GO:0035556	intracellular signal transduction	5.296190e-5
GO:0010042	response to manganese ion	5.370067e-5
GO:0042346	positive regulation of NF-kappaB import into nucleus	5.476424e-5
GO:0002675	positive regulation of acute inflammatory response	5.642407e-5
GO:0070373	negative regulation of ERK1 and ERK2 cascade	5.642407e-5
GO:0030258	lipid modification	5.692262e-5
GO:0002708	positive regulation of lymphocyte mediated immunity	5.710623e-5
GO:0032869	cellular response to insulin stimulus	5.769376e-5
GO:0070741	response to interleukin-6	5.853794e-5
GO:0031343	positive regulation of cell killing	6.054349e-5
GO:0061024	membrane organization	6.157894e-5
GO:0045821	positive regulation of glycolysis	6.264569e-5
GO:0050728	negative regulation of inflammatory response	6.545311e-5
GO:0022610	biological adhesion	6.603925e-5
GO:0032653	regulation of interleukin-10 production	6.654592e-5
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	7.318446e-5
GO:0032868	response to insulin stimulus	7.574712e-5
GO:0051260	protein homooligomerization	7.665413e-5
GO:0032703	negative regulation of interleukin-2 production	7.994819e-5
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	8.543639e-5
GO:0006959	humoral immune response	8.571372e-5
GO:0002318	myeloid progenitor cell differentiation	8.581593e-5
GO:0045540	regulation of cholesterol biosynthetic process	8.587494e-5
GO:0046459	short-chain fatty acid metabolic process	8.644731e-5
GO:0002377	immunoglobulin production	8.768346e-5
GO:0032753	positive regulation of interleukin-4 production	8.868755e-5
GO:0051056	regulation of small GTPase mediated signal transduction	8.909462e-5
GO:0048738	cardiac muscle tissue development	8.997136e-5
GO:0010885	regulation of cholesterol storage	9.346304e-5
GO:0019221	cytokine-mediated signaling pathway	9.353249e-5
GO:0006508	proteolysis	9.946701e-5
GO:0006750	glutathione biosynthetic process	9.963846e-5
GO:0001510	RNA methylation	1.010327e-4
GO:0046326	positive regulation of glucose import	1.012907e-4
GO:0000041	transition metal ion transport	1.025335e-4
GO:0007155	cell adhesion	1.035331e-4
GO:0010741	negative regulation of intracellular protein kinase cascade	1.039588e-4
GO:0043471	regulation of cellular carbohydrate catabolic process	1.050428e-4
GO:0060948	cardiac vascular smooth muscle cell development	1.059627e-4
GO:0031295	T cell costimulation	1.100295e-4
GO:0031622	positive regulation of fever generation	1.115870e-4
GO:0048856	anatomical structure development	1.233639e-4
GO:0060479	lung cell differentiation	1.252200e-4
GO:0060486	Clara cell differentiation	1.280568e-4
GO:0002699	positive regulation of immune effector process	1.357677e-4
GO:0048870	cell motility	1.363038e-4
GO:0048840	otolith development	1.385800e-4
GO:0045321	leukocyte activation	1.396186e-4
GO:0021559	trigeminal nerve development	1.424407e-4
GO:0050789	regulation of biological process	1.458487e-4
GO:0045428	regulation of nitric oxide biosynthetic process	1.473776e-4
GO:0009308	amine metabolic process	1.500160e-4
GO:0002858	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	1.546070e-4
GO:0006520	cellular amino acid metabolic process	1.627768e-4
GO:0010660	regulation of muscle cell apoptosis	1.634269e-4
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	1.656679e-4
GO:0022406	membrane docking	1.658265e-4
GO:0002252	immune effector process	1.683329e-4
GO:0051262	protein tetramerization	1.696101e-4
GO:0031620	regulation of fever generation	1.729930e-4
GO:0060487	lung epithelial cell differentiation	1.734760e-4
GO:0012501	programmed cell death	1.744735e-4
GO:0019371	cyclooxygenase pathway	1.779943e-4
GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis	1.813199e-4
GO:2000791	negative regulation of mesenchymal cell proliferation involved in lung development	1.813199e-4
GO:0061141	lung ciliated cell differentiation	1.813199e-4
GO:0021740	principal sensory nucleus of trigeminal nerve development	1.813199e-4
GO:0051049	regulation of transport	1.817368e-4
GO:0048015	phosphatidylinositol-mediated signaling	1.870734e-4
GO:0070633	transepithelial transport	1.928074e-4
GO:0010951	negative regulation of endopeptidase activity	1.946517e-4
GO:0032108	negative regulation of response to nutrient levels	2.058940e-4
GO:0071356	cellular response to tumor necrosis factor	2.090935e-4
GO:0060992	response to fungicide	2.100005e-4
GO:0006893	Golgi to plasma membrane transport	2.110388e-4
GO:0042127	regulation of cell proliferation	2.139144e-4
GO:0090181	regulation of cholesterol metabolic process	2.150666e-4
GO:0035690	cellular response to drug	2.322415e-4
GO:0050900	leukocyte migration	2.383458e-4
GO:0006422	aspartyl-tRNA aminoacylation	2.434569e-4
GO:0003029	detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	2.492824e-4
GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	2.516881e-4
GO:0009991	response to extracellular stimulus	2.517141e-4
GO:0002248	connective tissue replacement involved in inflammatory response wound healing	2.544698e-4
GO:0042421	norepinephrine biosynthetic process	2.564250e-4
GO:0010627	regulation of intracellular protein kinase cascade	2.692058e-4
GO:0019374	galactolipid metabolic process	2.702813e-4
GO:0046578	regulation of Ras protein signal transduction	2.724537e-4
GO:0033273	response to vitamin	2.749141e-4
GO:0030282	bone mineralization	2.757249e-4
GO:0006904	vesicle docking involved in exocytosis	2.809490e-4
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	2.813455e-4
GO:0033197	response to vitamin E	2.821742e-4
GO:0010661	positive regulation of muscle cell apoptosis	2.832932e-4
GO:0006583	melanin biosynthetic process from tyrosine	2.836437e-4
GO:0006575	cellular modified amino acid metabolic process	2.846628e-4
GO:0021602	cranial nerve morphogenesis	2.849699e-4
GO:0032814	regulation of natural killer cell activation	2.938093e-4
GO:0032944	regulation of mononuclear cell proliferation	2.946228e-4
GO:0032107	regulation of response to nutrient levels	2.970824e-4
GO:0010912	positive regulation of isomerase activity	3.051872e-4
GO:0023021	termination of signal transduction	3.098544e-4
GO:0016125	sterol metabolic process	3.160489e-4
GO:0006935	chemotaxis	3.182549e-4
GO:0042993	positive regulation of transcription factor import into nucleus	3.225299e-4
GO:0009566	fertilization	3.226293e-4
GO:0051454	intracellular pH elevation	3.297246e-4
GO:0021636	trigeminal nerve morphogenesis	3.303277e-4
GO:0003348	cardiac endothelial cell differentiation	3.303277e-4
GO:0031667	response to nutrient levels	3.371195e-4
GO:0010459	negative regulation of heart rate	3.375682e-4
GO:0007017	microtubule-based process	3.387443e-4
GO:0050670	regulation of lymphocyte proliferation	3.407714e-4
GO:0006685	sphingomyelin catabolic process	3.420077e-4
GO:0051898	negative regulation of protein kinase B signaling cascade	3.425722e-4
GO:0071316	cellular response to nicotine	3.453557e-4
GO:0002439	chronic inflammatory response to antigenic stimulus	3.453557e-4
GO:2000351	regulation of endothelial cell apoptosis	3.458380e-4
GO:0002697	regulation of immune effector process	3.482741e-4
GO:0002683	negative regulation of immune system process	3.565854e-4
GO:0007275	multicellular organismal development	3.575756e-4
GO:0032418	lysosome localization	3.600871e-4
GO:0007493	endodermal cell fate determination	3.611268e-4
GO:0048878	chemical homeostasis	3.642746e-4
GO:0048821	erythrocyte development	3.686546e-4
GO:0043001	Golgi to plasma membrane protein transport	3.730775e-4
GO:0070663	regulation of leukocyte proliferation	3.736347e-4
GO:0031581	hemidesmosome assembly	3.766732e-4
GO:0071375	cellular response to peptide hormone stimulus	3.783723e-4
GO:0048286	lung alveolus development	4.047864e-4
GO:0031649	heat generation	4.065213e-4
GO:0009052	pentose-phosphate shunt, non-oxidative branch	4.068253e-4
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	4.089885e-4
GO:0042330	taxis	4.211132e-4
GO:0045075	regulation of interleukin-12 biosynthetic process	4.228337e-4
GO:0019852	L-ascorbic acid metabolic process	4.271203e-4
GO:0008219	cell death	4.288590e-4
GO:0002024	diet induced thermogenesis	4.344793e-4
GO:0032088	negative regulation of NF-kappaB transcription factor activity	4.385078e-4
GO:0034393	positive regulation of smooth muscle cell apoptosis	4.453925e-4
GO:0009966	regulation of signal transduction	4.550869e-4
GO:0048771	tissue remodeling	4.646569e-4
GO:0032816	positive regulation of natural killer cell activation	4.694467e-4
GO:0030889	negative regulation of B cell proliferation	4.745940e-4
GO:0016265	death	4.880232e-4
GO:0042102	positive regulation of T cell proliferation	4.895972e-4
GO:0014874	response to stimulus involved in regulation of muscle adaptation	4.907301e-4
GO:0009181	purine ribonucleoside diphosphate catabolic process	5.093294e-4
GO:0051541	elastin metabolic process	5.123235e-4
GO:2000352	negative regulation of endothelial cell apoptosis	5.154018e-4
GO:0002520	immune system development	5.307434e-4
GO:0045123	cellular extravasation	5.336682e-4
GO:0042129	regulation of T cell proliferation	5.347337e-4
GO:0006704	glucocorticoid biosynthetic process	5.380071e-4
GO:0002444	myeloid leukocyte mediated immunity	5.385265e-4
GO:0019218	regulation of steroid metabolic process	5.432904e-4
GO:0033043	regulation of organelle organization	5.496695e-4
GO:0006833	water transport	5.572840e-4
GO:0010677	negative regulation of cellular carbohydrate metabolic process	5.592019e-4
GO:0043279	response to alkaloid	5.643875e-4
GO:0007519	skeletal muscle tissue development	5.671832e-4
GO:0042780	tRNA 3'-end processing	5.751221e-4
GO:0051893	regulation of focal adhesion assembly	5.834749e-4
GO:0034115	negative regulation of heterotypic cell-cell adhesion	5.921981e-4
GO:0031122	cytoplasmic microtubule organization	5.939960e-4
GO:0001711	endodermal cell fate commitment	5.939960e-4
GO:0042345	regulation of NF-kappaB import into nucleus	5.950980e-4
GO:0006700	C21-steroid hormone biosynthetic process	6.024582e-4
GO:0051259	protein oligomerization	6.105865e-4
GO:0043271	negative regulation of ion transport	6.176426e-4
GO:0000729	DNA double-strand break processing	6.186295e-4
GO:0043255	regulation of carbohydrate biosynthetic process	6.226755e-4
GO:0032911	negative regulation of transforming growth factor beta1 production	6.435178e-4
GO:0046006	regulation of activated T cell proliferation	6.435591e-4
GO:0048278	vesicle docking	6.438437e-4
GO:0060627	regulation of vesicle-mediated transport	6.486654e-4
GO:0046483	heterocycle metabolic process	6.523417e-4
GO:0046649	lymphocyte activation	6.552229e-4
GO:0048534	hemopoietic or lymphoid organ development	6.676902e-4
GO:0051462	regulation of cortisol secretion	6.687382e-4
GO:0002839	positive regulation of immune response to tumor cell	6.699403e-4
GO:0032095	regulation of response to food	6.716917e-4
GO:0006681	galactosylceramide metabolic process	6.768267e-4
GO:0002639	positive regulation of immunoglobulin production	6.772572e-4
GO:0010466	negative regulation of peptidase activity	6.947104e-4
GO:0006915	apoptosis	6.966089e-4
GO:0021502	neural fold elevation formation	7.042276e-4
GO:0048731	system development	7.083643e-4
GO:0046058	cAMP metabolic process	7.097074e-4
GO:0042044	fluid transport	7.132771e-4
GO:0015706	nitrate transport	7.256766e-4
GO:0002355	detection of tumor cell	7.256766e-4
GO:0009450	gamma-aminobutyric acid catabolic process	7.256766e-4
GO:0000920	cytokinetic cell separation	7.262046e-4
GO:0016553	base conversion or substitution editing	7.274090e-4
GO:0010883	regulation of lipid storage	7.376857e-4
GO:0002428	antigen processing and presentation of peptide antigen via MHC class Ib	7.396020e-4
GO:0006171	cAMP biosynthetic process	7.563040e-4
GO:0030097	hemopoiesis	7.589007e-4
GO:0010470	regulation of gastrulation	7.615435e-4
GO:0071732	cellular response to nitric oxide	7.742436e-4
GO:0032909	regulation of transforming growth factor beta2 production	7.933534e-4
GO:0002093	auditory receptor cell morphogenesis	7.933534e-4
GO:0032012	regulation of ARF protein signal transduction	7.989823e-4
GO:0015031	protein transport	8.142045e-4
GO:0045576	mast cell activation	8.420062e-4
GO:0010954	positive regulation of protein processing	8.523201e-4
GO:0002053	positive regulation of mesenchymal cell proliferation	8.526232e-4
GO:0042851	L-alanine metabolic process	8.616143e-4
GO:0032715	negative regulation of interleukin-6 production	8.690243e-4
GO:0046426	negative regulation of JAK-STAT cascade	8.881499e-4
GO:0001975	response to amphetamine	8.897654e-4
GO:0032675	regulation of interleukin-6 production	9.003551e-4
GO:0032621	interleukin-18 production	9.057868e-4
GO:0002638	negative regulation of immunoglobulin production	9.057868e-4
GO:0001811	negative regulation of type I hypersensitivity	9.057868e-4
GO:0050801	ion homeostasis	9.123216e-4
GO:0006467	protein thiol-disulfide exchange	9.151644e-4
GO:0002837	regulation of immune response to tumor cell	9.171187e-4
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	9.207778e-4
GO:0050756	fractalkine metabolic process	9.278433e-4
GO:0033595	response to genistein	9.278433e-4
GO:0006059	hexitol metabolic process	9.278433e-4
GO:0006701	progesterone biosynthetic process	9.278433e-4
GO:0021793	chemorepulsion of branchiomotor axon	9.278433e-4
GO:0001666	response to hypoxia	9.288762e-4
GO:0010884	positive regulation of lipid storage	9.451363e-4
GO:0009068	aspartate family amino acid catabolic process	9.631260e-4
GO:0008584	male gonad development	9.650958e-4
GO:0032908	regulation of transforming growth factor beta1 production	9.670333e-4
GO:0006635	fatty acid beta-oxidation	9.707149e-4
GO:0021610	facial nerve morphogenesis	9.910165e-4
GO:0005979	regulation of glycogen biosynthetic process	9.922648e-4
GO:0008285	negative regulation of cell proliferation	1.001338e-3
GO:0032693	negative regulation of interleukin-10 production	1.007102e-3
GO:0030220	platelet formation	1.017327e-3
GO:0001659	temperature homeostasis	1.022743e-3
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	1.033268e-3
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	1.042601e-3
GO:0042220	response to cocaine	1.052575e-3
GO:0001816	cytokine production	1.055464e-3
GO:0045184	establishment of protein localization	1.058384e-3
GO:0048522	positive regulation of cellular process	1.064195e-3
GO:0050798	activated T cell proliferation	1.068767e-3
GO:0021954	central nervous system neuron development	1.073493e-3
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	1.105281e-3
GO:0030098	lymphocyte differentiation	1.113814e-3
GO:0022029	telencephalon cell migration	1.125045e-3
GO:0015672	monovalent inorganic cation transport	1.155442e-3
GO:0071634	regulation of transforming growth factor beta production	1.173445e-3
GO:0002478	antigen processing and presentation of exogenous peptide antigen	1.173445e-3
GO:0019395	fatty acid oxidation	1.190371e-3
GO:0071805	potassium ion transmembrane transport	1.193404e-3
GO:0051900	regulation of mitochondrial depolarization	1.199306e-3
GO:0030850	prostate gland development	1.200758e-3
GO:0021884	forebrain neuron development	1.204657e-3
GO:0051295	establishment of meiotic spindle localization	1.207433e-3
GO:0050793	regulation of developmental process	1.236127e-3
GO:0009628	response to abiotic stimulus	1.240684e-3
GO:0042110	T cell activation	1.248228e-3
GO:0030500	regulation of bone mineralization	1.263502e-3