MCL coexpression mm9:331
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 8.11094323245837e-05 |
| GO:0007242 | intracellular signaling cascade | 0.00196897682908386 |
| GO:0004713 | protein-tyrosine kinase activity | 0.00196897682908386 |
| GO:0007165 | signal transduction | 0.00713790286926552 |
| GO:0007154 | cell communication | 0.00854678678617675 |
| GO:0016299 | regulator of G-protein signaling activity | 0.0192255013928163 |
| GO:0004672 | protein kinase activity | 0.032023213734179 |
| GO:0007250 | activation of NF-kappaB-inducing kinase | 0.032023213734179 |
| GO:0006468 | protein amino acid phosphorylation | 0.032023213734179 |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 0.033607780848479 |
| GO:0016310 | phosphorylation | 0.033607780848479 |
| GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 0.033607780848479 |
| GO:0006793 | phosphorus metabolic process | 0.0452943172759087 |
| GO:0006796 | phosphate metabolic process | 0.0452943172759087 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| intestinal crypt stem cell | 1.12e-10 | 3 |
| transporting cell | 3.09e-10 | 3 |
| M cell of gut | 3.09e-10 | 3 |
| intestinal epithelial cell | 2.33e-09 | 9 |
| epithelial cell of alimentary canal | 2.33e-09 | 9 |
| epithelial cell | 2.34e-07 | 25 |
| Ontology term | p-value | n |
|---|---|---|
| gastrointestinal system | 1.16e-20 | 47 |
| intestine | 1.66e-20 | 31 |
| mucosa | 5.55e-17 | 15 |
| intestinal mucosa | 5.82e-12 | 13 |
| anatomical wall | 5.82e-12 | 13 |
| wall of intestine | 5.82e-12 | 13 |
| gastrointestinal system mucosa | 5.82e-12 | 13 |
| digestive system | 4.11e-11 | 116 |
| digestive tract | 4.11e-11 | 116 |
| primitive gut | 4.11e-11 | 116 |
| endoderm-derived structure | 7.64e-11 | 118 |
| endoderm | 7.64e-11 | 118 |
| presumptive endoderm | 7.64e-11 | 118 |
| organ component layer | 5.34e-10 | 24 |
| epithelium of mucosa | 2.33e-09 | 9 |
| gastrointestinal system epithelium | 2.33e-09 | 9 |
| intestinal epithelium | 2.33e-09 | 9 |
| subdivision of digestive tract | 5.97e-09 | 114 |
| gut-associated lymphoid tissue | 6.90e-08 | 2 |
| mucosa-associated lymphoid tissue | 6.90e-08 | 2 |
| lymphoid tissue | 6.90e-08 | 2 |
| simple columnar epithelium | 1.37e-07 | 11 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.000310914 |
| MA0004.1 | 0.126659 |
| MA0006.1 | 0.0460466 |
| MA0007.1 | 0.376537 |
| MA0009.1 | 0.452863 |
| MA0014.1 | 0.000122002 |
| MA0017.1 | 0.205754 |
| MA0019.1 | 0.818593 |
| MA0024.1 | 0.415603 |
| MA0025.1 | 0.660968 |
| MA0027.1 | 2.04174 |
| MA0028.1 | 0.0499059 |
| MA0029.1 | 0.397373 |
| MA0030.1 | 0.402861 |
| MA0031.1 | 0.373333 |
| MA0038.1 | 0.62805 |
| MA0040.1 | 0.463641 |
| MA0041.1 | 0.290933 |
| MA0042.1 | 0.273359 |
| MA0043.1 | 0.53743 |
| MA0046.1 | 0.483941 |
| MA0048.1 | 0.023533 |
| MA0050.1 | 0.149886 |
| MA0051.1 | 0.226644 |
| MA0052.1 | 0.47061 |
| MA0055.1 | 0.232159 |
| MA0056.1 | 0 |
| MA0057.1 | 0.14014 |
| MA0058.1 | 0.0765185 |
| MA0059.1 | 0.0823381 |
| MA0060.1 | 0.0949887 |
| MA0061.1 | 0.537954 |
| MA0063.1 | 0 |
| MA0066.1 | 0.212546 |
| MA0067.1 | 0.764133 |
| MA0068.1 | 0.0650147 |
| MA0069.1 | 0.470904 |
| MA0070.1 | 0.462521 |
| MA0071.1 | 0.456242 |
| MA0072.1 | 0.455219 |
| MA0073.1 | 0.0007102 |
| MA0074.1 | 0.550954 |
| MA0076.1 | 0.064121 |
| MA0077.1 | 2.90324 |
| MA0078.1 | 0.250627 |
| MA0081.1 | 0.644573 |
| MA0083.1 | 0.536725 |
| MA0084.1 | 1.07765 |
| MA0087.1 | 0.4987 |
| MA0088.1 | 0.149641 |
| MA0089.1 | 0 |
| MA0090.1 | 0.708683 |
| MA0091.1 | 1.34177 |
| MA0092.1 | 0.107655 |
| MA0093.1 | 0.0530878 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.180237 |
| MA0101.1 | 0.292678 |
| MA0103.1 | 0.476679 |
| MA0105.1 | 0.118663 |
| MA0106.1 | 0.256379 |
| MA0107.1 | 0.462865 |
| MA0108.2 | 0.85894 |
| MA0109.1 | 0 |
| MA0111.1 | 0.369101 |
| MA0113.1 | 0.2357 |
| MA0114.1 | 0.530742 |
| MA0115.1 | 0.539917 |
| MA0116.1 | 0.174756 |
| MA0117.1 | 0.511373 |
| MA0119.1 | 0.293473 |
| MA0122.1 | 0.528896 |
| MA0124.1 | 1.7 |
| MA0125.1 | 0.646095 |
| MA0130.1 | 0 |
| MA0131.1 | 0.299487 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.569948 |
| MA0136.1 | 0.201456 |
| MA0139.1 | 0.0699025 |
| MA0140.1 | 0.532112 |
| MA0141.1 | 0.24332 |
| MA0142.1 | 1.69142 |
| MA0143.1 | 1.28115 |
| MA0144.1 | 0.540257 |
| MA0145.1 | 0.171363 |
| MA0146.1 | 0.0147284 |
| MA0147.1 | 0.0335355 |
| MA0148.1 | 0.836385 |
| MA0149.1 | 0.0894222 |
| MA0062.2 | 0.0449909 |
| MA0035.2 | 1.63216 |
| MA0039.2 | 0.0131673 |
| MA0138.2 | 0.796689 |
| MA0002.2 | 1.67165 |
| MA0137.2 | 0.0677978 |
| MA0104.2 | 0.0185242 |
| MA0047.2 | 1.17521 |
| MA0112.2 | 0.00977802 |
| MA0065.2 | 0.461871 |
| MA0150.1 | 0.376372 |
| MA0151.1 | 0 |
| MA0152.1 | 1.1755 |
| MA0153.1 | 0.584906 |
| MA0154.1 | 0.0704998 |
| MA0155.1 | 0.354426 |
| MA0156.1 | 0.227959 |
| MA0157.1 | 0.335532 |
| MA0158.1 | 0 |
| MA0159.1 | 0.036714 |
| MA0160.1 | 0.427566 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0223877 |
| MA0163.1 | 0.00646064 |
| MA0164.1 | 0.583987 |
| MA0080.2 | 0.806441 |
| MA0018.2 | 0.208409 |
| MA0099.2 | 0.288477 |
| MA0079.2 | 1.27548e-07 |
| MA0102.2 | 1.12863 |
| MA0258.1 | 0.107482 |
| MA0259.1 | 0.296386 |
| MA0442.1 | 0 |
