MCL coexpression mm9:3219

Phase1 CAGE Peaks

	Short description
Mm9::chr1:107560446..107560497,+	p1@2310035C23Rik
Mm9::chr3:152009429..152009495,+	p1@Usp33
Mm9::chr9:64880220..64880273,+	p1@Dpp8

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004274	dipeptidyl-peptidase IV activity	0.011527492729213
GO:0008239	dipeptidyl-peptidase activity	0.011527492729213
GO:0016806	dipeptidyl-peptidase and tripeptidyl-peptidase activity	0.011527492729213
GO:0008233	peptidase activity	0.011527492729213
GO:0004177	aminopeptidase activity	0.0283509095421994
GO:0004221	ubiquitin thiolesterase activity	0.0325375515202056
GO:0004843	ubiquitin-specific protease activity	0.0325375515202056
GO:0019783	small conjugating protein-specific protease activity	0.0325375515202056
GO:0016790	thiolester hydrolase activity	0.0359570282017172
GO:0008238	exopeptidase activity	0.0359570282017172
GO:0016787	hydrolase activity	0.0394152488012717
GO:0008234	cysteine-type peptidase activity	0.0429744633852751
GO:0004252	serine-type endopeptidase activity	0.0429744633852751
GO:0044267	cellular protein metabolic process	0.0429744633852751
GO:0044260	cellular macromolecule metabolic process	0.0429744633852751
GO:0008236	serine-type peptidase activity	0.0429744633852751
GO:0017171	serine hydrolase activity	0.0429744633852751
GO:0019538	protein metabolic process	0.0429744633852751

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	2.51e-07	23
neuroblast (sensu Vertebrata)	2.51e-07	23

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	1.04e-11	54
gray matter	1.28e-11	34
neural tube	1.21e-10	52
neural rod	1.21e-10	52
future spinal cord	1.21e-10	52
neural keel	1.21e-10	52
brain grey matter	1.96e-09	29
regional part of telencephalon	1.96e-09	29
telencephalon	1.96e-09	29
central nervous system	4.35e-09	73
neurectoderm	8.36e-09	64
neural plate	8.36e-09	64
presumptive neural plate	8.36e-09	64
nervous system	9.69e-09	75
brain	1.28e-08	47
future brain	1.28e-08	47
ecto-epithelium	1.44e-08	73
ectoderm-derived structure	2.32e-08	95
ectoderm	2.32e-08	95
presumptive ectoderm	2.32e-08	95
regional part of brain	3.47e-08	46
occipital lobe	5.94e-08	10
visual cortex	5.94e-08	10
neocortex	5.94e-08	10
anterior neural tube	8.36e-08	40
organ system subdivision	1.14e-07	194
regional part of forebrain	2.25e-07	39
forebrain	2.25e-07	39
future forebrain	2.25e-07	39
pre-chordal neural plate	3.68e-07	49

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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