MCL coexpression mm9:2107

Phase1 CAGE Peaks

	Short description
Mm9::chr14:51710846..51710867,+	p3@Ang p3@Rnase4
Mm9::chr2:84614953..84614964,-	p5@Serping1
Mm9::chr2:84614966..84615017,-	p1@Serping1
Mm9::chr2:84615020..84615033,-	p4@Serping1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004522	pancreatic ribonuclease activity	0.0249339931844607
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	0.0249339931844607
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	0.0249339931844607
GO:0006958	complement activation, classical pathway	0.0249339931844607
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.0249339931844607
GO:0004521	endoribonuclease activity	0.0249339931844607
GO:0002541	activation of plasma proteins during acute inflammatory response	0.0249339931844607
GO:0006956	complement activation	0.0249339931844607
GO:0007596	blood coagulation	0.0249339931844607
GO:0007599	hemostasis	0.0249339931844607
GO:0050817	coagulation	0.0249339931844607
GO:0004540	ribonuclease activity	0.0249339931844607
GO:0050878	regulation of body fluid levels	0.0249339931844607
GO:0016064	immunoglobulin mediated immune response	0.0249339931844607
GO:0019724	B cell mediated immunity	0.0249339931844607
GO:0002526	acute inflammatory response	0.0249339931844607
GO:0002253	activation of immune response	0.0249339931844607
GO:0042060	wound healing	0.0249339931844607
GO:0004519	endonuclease activity	0.0249339931844607
GO:0045087	innate immune response	0.0249339931844607
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0249339931844607
GO:0002250	adaptive immune response	0.0249339931844607
GO:0002449	lymphocyte mediated immunity	0.0249339931844607
GO:0050778	positive regulation of immune response	0.0249339931844607
GO:0002684	positive regulation of immune system process	0.0249339931844607
GO:0002443	leukocyte mediated immunity	0.0249339931844607
GO:0004867	serine-type endopeptidase inhibitor activity	0.0249339931844607
GO:0050776	regulation of immune response	0.0259639934272105
GO:0002682	regulation of immune system process	0.0259639934272105
GO:0051240	positive regulation of multicellular organismal process	0.0259841140737432
GO:0004518	nuclease activity	0.027443623303524
GO:0002252	immune effector process	0.027443623303524
GO:0006959	humoral immune response	0.027443623303524
GO:0004866	endopeptidase inhibitor activity	0.0277703825651687
GO:0030414	protease inhibitor activity	0.0277703825651687
GO:0004857	enzyme inhibitor activity	0.0373609115185842
GO:0006954	inflammatory response	0.0373609115185842
GO:0051239	regulation of multicellular organismal process	0.0485264690248685
GO:0009611	response to wounding	0.0489694780402281

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk	1.81e-12	90
trunk region element	3.40e-11	79
immaterial anatomical entity	2.65e-10	79
multi-cellular organism	1.48e-09	333
subdivision of trunk	1.29e-08	66
mesenchyme	6.68e-08	61
entire embryonic mesenchyme	6.68e-08	61
trunk mesenchyme	1.04e-07	45
anatomical space	1.18e-07	57
epithelial tube	2.53e-07	47
tissue	2.65e-07	349
organism subdivision	2.68e-07	150

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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