MCL coexpression mm9:1418

Phase1 CAGE Peaks

	Short description
Mm9::chr19:34953822..34953888,-	p3@Pank1
Mm9::chr1:166829711..166829727,-	p@chr1:166829711..166829727 -
Mm9::chr1:189432857..189432870,+	p7@Esrrg
Mm9::chr1:189432881..189432903,+	p2@Esrrg
Mm9::chr1:189432907..189432926,+	p3@Esrrg
Mm9::chr4:120488308..120488366,-	p1@Nfyc

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050682	AF-2 domain binding	0.00437322249490112
GO:0045893	positive regulation of transcription, DNA-dependent	0.00437322249490112
GO:0045941	positive regulation of transcription	0.00437322249490112
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00437322249490112
GO:0031325	positive regulation of cellular metabolic process	0.00479707233637392
GO:0009893	positive regulation of metabolic process	0.00479707233637392
GO:0043565	sequence-specific DNA binding	0.00556400150565914
GO:0016439	tRNA-pseudouridine synthase activity	0.012219825711145
GO:0048522	positive regulation of cellular process	0.012219825711145
GO:0003700	transcription factor activity	0.012219825711145
GO:0009982	pseudouridine synthase activity	0.012219825711145
GO:0048518	positive regulation of biological process	0.012219825711145
GO:0016866	intramolecular transferase activity	0.0173410538729427
GO:0005496	steroid binding	0.0260841264964928
GO:0019904	protein domain specific binding	0.0274485626190369
GO:0006355	regulation of transcription, DNA-dependent	0.035536894862443
GO:0006351	transcription, DNA-dependent	0.035536894862443
GO:0032774	RNA biosynthetic process	0.035536894862443
GO:0003677	DNA binding	0.035536894862443
GO:0045449	regulation of transcription	0.035536894862443
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.035536894862443
GO:0006350	transcription	0.035536894862443
GO:0005516	calmodulin binding	0.035536894862443
GO:0010468	regulation of gene expression	0.035536894862443
GO:0031323	regulation of cellular metabolic process	0.0369695037747075
GO:0019222	regulation of metabolic process	0.0382249283767296
GO:0016070	RNA metabolic process	0.0387779922786696
GO:0016853	isomerase activity	0.0420571120835355
GO:0016563	transcription activator activity	0.047518768087866
GO:0010467	gene expression	0.049980793853034

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
compound organ	2.05e-09	43
primary circulatory organ	1.15e-08	18
heart	1.15e-08	18
primitive heart tube	1.15e-08	18
primary heart field	1.15e-08	18
anterior lateral plate mesoderm	1.15e-08	18
heart tube	1.15e-08	18
heart primordium	1.15e-08	18
cardiac mesoderm	1.15e-08	18
cardiogenic plate	1.15e-08	18
heart rudiment	1.15e-08	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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