MCL coexpression mm9:994

Phase1 CAGE Peaks

	Short description
Mm9::chr5:120020745..120020748,-	p@chr5:120020745..120020748 -
Mm9::chr5:120121262..120121282,+	p6@Tbx3
Mm9::chr5:120121369..120121378,-	p3@ENSMUST00000129108
Mm9::chr5:120121387..120121407,-	p1@ENSMUST00000129108
Mm9::chr5:120121507..120121519,-	p2@ENSMUST00000129108
Mm9::chr5:120121599..120121622,+	p@chr5:120121599..120121622 +
Mm9::chr5:120121661..120121671,+	p@chr5:120121661..120121671 +
Mm9::chr5:120121692..120121708,+	p@chr5:120121692..120121708 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0021761	limbic system development	0.0219142058839643
GO:0007569	cell aging	0.0219142058839643
GO:0035136	forelimb morphogenesis	0.0219142058839643
GO:0030879	mammary gland development	0.0241056264723607
GO:0007568	aging	0.02454391059004
GO:0003007	heart morphogenesis	0.0248361000018262
GO:0048754	branching morphogenesis of a tube	0.0266341886897412
GO:0001763	morphogenesis of a branching structure	0.0266341886897412
GO:0048732	gland development	0.0266341886897412
GO:0035107	appendage morphogenesis	0.0266341886897412
GO:0035108	limb morphogenesis	0.0266341886897412
GO:0048736	appendage development	0.0266341886897412
GO:0060173	limb development	0.0266341886897412
GO:0030900	forebrain development	0.0313060084056633
GO:0001701	in utero embryonic development	0.0347705400025567
GO:0035239	tube morphogenesis	0.0372541500027393
GO:0016564	transcription repressor activity	0.0372541500027393
GO:0007507	heart development	0.0372541500027393
GO:0007420	brain development	0.0372541500027393
GO:0045892	negative regulation of transcription, DNA-dependent	0.0372541500027393
GO:0035295	tube development	0.0372541500027393
GO:0001568	blood vessel development	0.0372541500027393
GO:0001944	vasculature development	0.0372541500027393
GO:0043009	chordate embryonic development	0.0372541500027393
GO:0009792	embryonic development ending in birth or egg hatching	0.0372541500027393
GO:0007417	central nervous system development	0.0372541500027393
GO:0045893	positive regulation of transcription, DNA-dependent	0.0372541500027393
GO:0016481	negative regulation of transcription	0.0372541500027393
GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0385387758649027
GO:0045941	positive regulation of transcription	0.0399934257382348
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0399934257382348
GO:0031324	negative regulation of cellular metabolic process	0.0399934257382348
GO:0009892	negative regulation of metabolic process	0.0438284117679286
GO:0031325	positive regulation of cellular metabolic process	0.0449885756088443
GO:0009893	positive regulation of metabolic process	0.0460824443731363

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
autonomic neuron	2.09e-07	9

Uber Anatomy

Ontology term	p-value	n
epithelial fold	7.70e-10	20
multi-cellular organism	3.25e-09	333
lung	4.67e-09	14
respiratory tube	4.67e-09	14
respiration organ	4.67e-09	14
pair of lungs	4.67e-09	14
lung primordium	4.67e-09	14
lung bud	4.67e-09	14
intermediate mesoderm	4.13e-08	14
epithelial bud	6.79e-08	17
embryo	1.41e-07	320
autonomic nervous system	2.09e-07	9
urinary system structure	3.33e-07	18
renal system	6.47e-07	19

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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