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Coexpression cluster:C3114

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Full id: C3114_ductus_CD14_Monocytederived_pituitary_seminal_Macrophage_small



Phase1 CAGE Peaks

Hg19::chr11:128761220..128761257,+p1@KCNJ5
Hg19::chr11:128761363..128761382,+p2@KCNJ5
Hg19::chr11:128761387..128761409,+p3@KCNJ5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
respiratory epithelial cell2.69e-1013
macrophage5.75e-106
endocrine cell6.84e-079
Uber Anatomy
Ontology termp-valuen
adult organism9.32e-40114
neural tube1.02e-1756
neural rod1.02e-1756
future spinal cord1.02e-1756
neural keel1.02e-1756
neural plate5.32e-1682
presumptive neural plate5.32e-1682
regional part of nervous system3.89e-1553
regional part of brain3.89e-1553
neurectoderm1.02e-1486
ecto-epithelium2.63e-14104
structure with developmental contribution from neural crest8.57e-13132
regional part of forebrain4.49e-1241
forebrain4.49e-1241
anterior neural tube4.49e-1241
future forebrain4.49e-1241
organ6.80e-12503
central nervous system1.29e-1181
brain2.17e-1168
future brain2.17e-1168
brain grey matter3.14e-1134
gray matter3.14e-1134
telencephalon3.68e-1134
organ system subdivision5.79e-10223
regional part of telencephalon1.14e-0932
pre-chordal neural plate1.55e-0961
nervous system1.60e-0989
cerebral hemisphere1.80e-0932
organ part7.24e-09218
anatomical system9.31e-09624
anatomical group1.09e-08625
multi-cellular organism1.68e-08656
embryo2.26e-08592
developing anatomical structure2.92e-08581
neural nucleus3.40e-089
nucleus of brain3.40e-089
embryonic structure1.07e-07564
germ layer1.36e-07560
germ layer / neural crest1.36e-07560
embryonic tissue1.36e-07560
presumptive structure1.36e-07560
germ layer / neural crest derived structure1.36e-07560
epiblast (generic)1.36e-07560
posterior neural tube4.49e-0715
chordal neural plate4.49e-0715
regional part of cerebral cortex5.01e-0722
neocortex7.29e-0720
ectoderm-derived structure9.27e-07171
ectoderm9.27e-07171
presumptive ectoderm9.27e-07171
anatomical cluster9.40e-07373


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ZZZ3#260093239.4132124352337.25894005043406e-084.37458995918801e-06



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.