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Coexpression cluster:C2442

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Full id: C2442_Adipocyte_Cardiac_Mesenchymal_heart_mature_Hair_Smooth



Phase1 CAGE Peaks

Hg19::chr17:77020224..77020262,+p1@C1QTNF1
Hg19::chr17:77020273..77020288,+p4@C1QTNF1
Hg19::chr17:77020303..77020314,+p5@C1QTNF1
Hg19::chr17:77020325..77020348,+p2@C1QTNF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
multi-tissue structure1.34e-23342
multi-cellular organism1.21e-20656
anatomical cluster1.41e-20373
multilaminar epithelium7.37e-2083
cell layer2.72e-19309
epithelium3.34e-19306
dense mesenchyme tissue4.27e-1873
paraxial mesoderm4.87e-1872
presumptive paraxial mesoderm4.87e-1872
somite4.95e-1871
presomitic mesoderm4.95e-1871
presumptive segmental plate4.95e-1871
dermomyotome4.95e-1871
trunk paraxial mesoderm4.95e-1871
splanchnic layer of lateral plate mesoderm8.90e-1883
mesenchyme1.59e-17160
entire embryonic mesenchyme1.59e-17160
anatomical system1.92e-17624
anatomical group3.94e-17625
muscle tissue4.01e-1764
musculature4.01e-1764
musculature of body4.01e-1764
anatomical conduit9.72e-17240
skeletal muscle tissue1.05e-1662
striated muscle tissue1.05e-1662
myotome1.05e-1662
trunk mesenchyme1.24e-16122
organism subdivision1.57e-16264
epithelial vesicle4.77e-1678
primary circulatory organ1.84e-1527
embryonic structure3.43e-14564
embryo9.16e-14592
developing anatomical structure1.17e-13581
heart1.31e-1324
primitive heart tube1.31e-1324
primary heart field1.31e-1324
anterior lateral plate mesoderm1.31e-1324
heart tube1.31e-1324
heart primordium1.31e-1324
cardiac mesoderm1.31e-1324
cardiogenic plate1.31e-1324
heart rudiment1.31e-1324
germ layer2.25e-13560
germ layer / neural crest2.25e-13560
embryonic tissue2.25e-13560
presumptive structure2.25e-13560
germ layer / neural crest derived structure2.25e-13560
epiblast (generic)2.25e-13560
epithelial tube3.48e-13117
adult organism4.58e-13114
trunk6.32e-13199
circulatory system4.74e-12112
artery9.97e-1242
arterial blood vessel9.97e-1242
arterial system9.97e-1242
unilaminar epithelium1.04e-11148
vasculature1.42e-1178
vascular system1.42e-1178
structure with developmental contribution from neural crest2.31e-11132
systemic artery2.44e-1133
systemic arterial system2.44e-1133
tube2.66e-11192
epithelial tube open at both ends7.73e-1159
blood vessel7.73e-1159
blood vasculature7.73e-1159
vascular cord7.73e-1159
cardiovascular system8.18e-11109
vessel1.22e-1068
compound organ5.75e-1068
surface structure4.19e-0899
organ4.24e-08503
primordium4.79e-08160
smooth muscle tissue7.96e-0715
tissue8.69e-07773
Disease
Ontology termp-valuen
ovarian cancer3.99e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ZNF263#1012748.221841637010680.0002187871180958320.00248747091517642



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.