Coexpression cluster:C1998

Full id: C1998_liver_chorionic_placenta_tubular_Hepatocyte_lung_hepatocellular

Phase1 CAGE Peaks

Hg19::chr7:45928057..45928065,+	p8@IGFBP1
Hg19::chr7:45928079..45928095,+	p1@IGFBP1
Hg19::chr7:45928116..45928125,+	p5@IGFBP1
Hg19::chr7:45928178..45928184,+	p10@IGFBP1
Hg19::chr7:45928188..45928195,+	p6@IGFBP1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
metabolising cell	1.61e-16	12
endopolyploid cell	1.61e-16	12
parenchymal cell	1.61e-16	12
polyploid cell	1.61e-16	12
hepatocyte	1.61e-16	12
GAG secreting cell	1.31e-10	9
carbohydrate secreting cell	1.31e-10	9
extracellular matrix secreting cell	1.98e-09	15
collagen secreting cell	2.04e-09	6
chondroblast	2.04e-09	6
chondrocyte	2.04e-09	6
chorionic membrane mesenchymal stem cell	5.26e-09	3
meningothelial cell	3.40e-07	1

Uber Anatomy

Ontology term	p-value	n
liver	2.63e-18	19
digestive gland	2.63e-18	19
liver bud	2.63e-18	19
hepatic diverticulum	1.20e-15	22
liver primordium	1.20e-15	22
digestive tract diverticulum	6.45e-15	23
epithelial sac	1.25e-13	25
epithelium of foregut-midgut junction	1.25e-13	25
anatomical boundary	1.25e-13	25
hepatobiliary system	1.25e-13	25
foregut-midgut junction	1.25e-13	25
septum transversum	1.25e-13	25
sac	4.66e-13	26
endocrine gland	7.67e-12	35
endocrine system	4.34e-11	45
exocrine gland	9.25e-11	31
exocrine system	9.25e-11	31
acellular anatomical structure	5.26e-09	3
egg chorion	5.26e-09	3
chorion	2.34e-08	7
abdominal segment of trunk	9.45e-08	60
abdomen	9.45e-08	60
gut epithelium	3.68e-07	54
abdomen element	3.93e-07	54
abdominal segment element	3.93e-07	54

Disease

Ontology term	p-value	n
central nervous system cancer	3.40e-07	1
meningioma	3.40e-07	1
papillary adenocarcinoma	6.12e-07	1

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	5	4.90738921487932	0.000351281809925646	0.00353512439264064
EP300#2033	5	6.7739417262232	7.00901578206049e-05	0.00111045904014353
FOXA1#3169	5	11.0814197493855	5.98116883436141e-06	0.000179296008005704
FOXA2#3170	5	24.6304637526652	1.10174651693954e-07	6.41032336950688e-06
HEY1#23462	5	4.04011104310571	0.000928885220517799	0.00675005869368622
HNF4A#3172	5	23.1322903629537	1.50794906621644e-07	8.48538214044065e-06
MAFF#23764	5	56.3153564899452	1.76021388477016e-09	1.54094700680227e-07
NR3C1#2908	5	14.973023331173	1.32777388277837e-06	5.25867942902882e-05
SIN3A#25942	5	5.40888472681514	0.000215952267165727	0.00248362942743325
SP1#6667	5	5.6983813781409	0.00016639184371255	0.00204540934151307
TBP#6908	5	3.70677068709639	0.00142875510672112	0.00920472238546957
TCF7L2#6934	5	10.7701765631373	6.89693748574565e-06	0.000200197124534127
USF2#7392	4	10.3937579080557	0.000164617972868753	0.0020279000316631

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.