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Coexpression cluster:C1888

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Full id: C1888_hairy_migratory_immature_cord_mycosis_xeroderma_splenic



Phase1 CAGE Peaks

Hg19::chr2:201994490..201994538,+p7@CFLAR
Hg19::chr2:201994552..201994568,+p12@CFLAR
Hg19::chr2:201994569..201994583,+p18@CFLAR
Hg19::chr2:201994602..201994615,+p28@CFLAR
Hg19::chr7:141286151..141286162,+p@chr7:141286151..141286162
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm1.43e-1783
artery5.96e-1742
arterial blood vessel5.96e-1742
arterial system5.96e-1742
circulatory system6.11e-17112
vessel1.28e-1668
cardiovascular system4.35e-16109
vasculature6.64e-1678
vascular system6.64e-1678
epithelial tube open at both ends5.74e-1559
blood vessel5.74e-1559
blood vasculature5.74e-1559
vascular cord5.74e-1559
systemic artery3.04e-1433
systemic arterial system3.04e-1433
lateral plate mesoderm7.88e-14203
epithelial tube3.50e-11117
mesoderm3.43e-10315
mesoderm-derived structure3.43e-10315
presumptive mesoderm3.43e-10315
aorta1.07e-0821
aortic system1.07e-0821
skeletal muscle tissue3.45e-0862
striated muscle tissue3.45e-0862
myotome3.45e-0862
muscle tissue1.37e-0764
musculature1.37e-0764
musculature of body1.37e-0764
blood vessel smooth muscle6.26e-0710
arterial system smooth muscle6.26e-0710
artery smooth muscle tissue6.26e-0710
aorta smooth muscle tissue6.26e-0710
Disease
Ontology termp-valuen
ovarian cancer7.66e-1014


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
NFKB1#479055.488063424193840.0002008162847462320.00239199953953144
YY1#752843.928936599883080.007193866269917620.0298498291364293



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.