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Coexpression cluster:C1831

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Full id: C1831_testis_Eosinophils_CD14_Neutrophils_Basophils_Whole_Natural



Phase1 CAGE Peaks

Hg19::chr1:113162293..113162342,-p3@ST7L
Hg19::chr3:39194422..39194451,+p@chr3:39194422..39194451
+
Hg19::chr5:142388947..142388964,+p@chr5:142388947..142388964
+
Hg19::chr6:15248904..15248915,-p2@uc003nbk.2
Hg19::chr8:23386338..23386357,+p8@SLC25A37


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0048250mitochondrial iron ion transport0.0016484163428706
GO:0005381iron ion transmembrane transporter activity0.00494524902861179
GO:0046915transition metal ion transmembrane transporter activity0.0156599552572707
GO:0006839mitochondrial transport0.0156599552572707
GO:0015082di-, tri-valent inorganic cation transmembrane transporter activity0.0156599552572707
GO:0006826iron ion transport0.0156599552572707
GO:0007005mitochondrion organization and biogenesis0.0209584363593548
GO:0000041transition metal ion transport0.0210173083716001
GO:0015674di-, tri-valent inorganic cation transport0.0451666077946544
GO:0022890inorganic cation transmembrane transporter activity0.0451666077946544
GO:0005743mitochondrial inner membrane0.045468817457514
GO:0019866organelle inner membrane0.045468817457514



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte7.70e-5242
CD14-positive, CD16-negative classical monocyte7.70e-5242
myeloid leukocyte1.08e-4672
leukocyte6.45e-46136
defensive cell1.52e-4348
phagocyte1.52e-4348
hematopoietic stem cell1.21e-37168
angioblastic mesenchymal cell1.21e-37168
granulocyte monocyte progenitor cell2.29e-3767
hematopoietic cell1.35e-35177
nongranular leukocyte3.28e-35115
hematopoietic lineage restricted progenitor cell2.79e-34120
myeloid lineage restricted progenitor cell2.88e-3466
macrophage dendritic cell progenitor4.20e-3461
monopoietic cell8.40e-3459
monocyte8.40e-3459
monoblast8.40e-3459
promonocyte8.40e-3459
hematopoietic oligopotent progenitor cell1.30e-33161
hematopoietic multipotent progenitor cell1.30e-33161
myeloid cell1.07e-30108
common myeloid progenitor1.07e-30108
stuff accumulating cell5.01e-2087
granulocyte1.43e-138
mesenchymal cell9.76e-11354
connective tissue cell4.25e-10361
blood cell2.66e-0911
motile cell3.92e-09386
Uber Anatomy
Ontology termp-valuen
bone marrow7.95e-3376
hematopoietic system2.64e-3198
blood island2.64e-3198
bone element2.64e-2982
immune system4.38e-2993
hemolymphoid system6.60e-28108
skeletal element2.34e-2590
skeletal system2.43e-21100
connective tissue1.21e-09371
lateral plate mesoderm9.75e-08203
musculoskeletal system1.61e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672312.11053838593430.001127176470125940.00772803672050697
CCNT2#90545.068961261570110.002709998091280770.0148986413989194
CHD2#110636.206413700470110.007774550126275590.0319571095969024
CTCF#1066455.360256373075030.0002259278299937090.00249874792298135
E2F6#187644.013724585357910.006632118233933880.0283003798256924
FOS#235347.198364247115530.0006947858453382510.00559681750106298
JUN#3725410.01026335386910.0001908531347801070.00230540256110335
JUND#372756.994663941871035.97069468343598e-050.0009844859204979
RAD21#588548.284027116365060.0004011622639122450.00386717608277007
REST#597835.790017229676810.009468788694433940.0357033295710155
RFX5#599337.228746496317060.00502918278958660.0234671978090267
SMARCC1#6599217.46534372785260.005008037385199390.0233779294896902
SMC3#912639.02695970695970.002650964449467550.0146403720658845
SPI1#668846.563458806818180.0009957429636454020.00714198196416195
STAT3#677436.311678998292540.007411172122460540.030615275899757
TBP#690853.706770687096390.001428755106721120.00919168132258515
USF1#739145.089199421766370.00266867775360040.0147202934355272
YY1#752843.928936599883080.007193866269917620.0298450861747806
ZEB1#6935310.13305921052630.001895556924357070.0111639355790294



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.