Coexpression cluster:C601

Full id: C601_endometrial_clear_thyroid_kidney_Renal_serous_endometrioid

Phase1 CAGE Peaks

Hg19::chr18:43233616..43233624,+	p@chr18:43233616..43233624 +
Hg19::chr18:43233914..43233930,+	p@chr18:43233914..43233930 +
Hg19::chr19:12758382..12758427,-	p3@MAN2B1
Hg19::chr1:197927638..197927639,-	p@chr1:197927638..197927639 -
Hg19::chr1:81428697..81428704,-	p@chr1:81428697..81428704 -
Hg19::chr21:30550414..30550419,+	p@chr21:30550414..30550419 +
Hg19::chr2:191709136..191709144,-	p@chr2:191709136..191709144 -
Hg19::chr3:190105820..190105829,+	p3@CLDN16
Hg19::chr3:190105935..190105966,+	p1@CLDN16
Hg19::chr3:190106002..190106011,+	p4@CLDN16
Hg19::chr3:190106022..190106042,+	p2@CLDN16
Hg19::chr3:190109013..190109017,+	p@chr3:190109013..190109017 +
Hg19::chr4:56458309..56458322,-	p3@PDCL2
Hg19::chr5:13407920..13407929,-	p@chr5:13407920..13407929 -
Hg19::chr6:122974486..122974510,+	p@chr6:122974486..122974510 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015095	magnesium ion transmembrane transporter activity	0.00553388769969308
GO:0006517	protein deglycosylation	0.00553388769969308
GO:0004559	alpha-mannosidase activity	0.01844412029571
GO:0006013	mannose metabolic process	0.0199173041198385
GO:0006516	glycoprotein catabolic process	0.0199173041198385
GO:0016338	calcium-independent cell-cell adhesion	0.0202849484648906
GO:0015923	mannosidase activity	0.0270378374055664
GO:0007588	excretion	0.0270378374055664
GO:0007611	learning and/or memory	0.0270378374055664
GO:0015082	di-, tri-valent inorganic cation transmembrane transporter activity	0.0298601220329419
GO:0005923	tight junction	0.0428867924004245
GO:0043296	apical junction complex	0.0428867924004245
GO:0016327	apicolateral plasma membrane	0.0428867924004245
GO:0006875	cellular metal ion homeostasis	0.0428867924004245
GO:0055065	metal ion homeostasis	0.0428867924004245
GO:0050954	sensory perception of mechanical stimulus	0.0428867924004245
GO:0007605	sensory perception of sound	0.0428867924004245
GO:0005911	intercellular junction	0.0466783910941187
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	0.0466783910941187
GO:0030003	cellular cation homeostasis	0.0466783910941187
GO:0005764	lysosome	0.0466783910941187
GO:0000323	lytic vacuole	0.0466783910941187
GO:0055080	cation homeostasis	0.0466783910941187
GO:0009100	glycoprotein metabolic process	0.0466783910941187
GO:0016798	hydrolase activity, acting on glycosyl bonds	0.0466783910941187
GO:0005773	vacuole	0.0466783910941187
GO:0055082	cellular chemical homeostasis	0.0466783910941187
GO:0006873	cellular ion homeostasis	0.0466783910941187
GO:0050801	ion homeostasis	0.0471942131820465
GO:0019318	hexose metabolic process	0.0471942131820465
GO:0022890	inorganic cation transmembrane transporter activity	0.0471942131820465
GO:0005996	monosaccharide metabolic process	0.0471942131820465
GO:0007610	behavior	0.0489368997340565
GO:0048878	chemical homeostasis	0.0489368997340565

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell of uterus	2.19e-12	6
stromal cell of endometrium	2.19e-12	6

Disease

Ontology term	p-value	n
female reproductive endometrioid cancer	2.19e-12	6

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.