Coexpression cluster:C532

Full id: C532_Mast_CD14_Eosinophils_seminal_ductus_Neutrophils_Smooth

Phase1 CAGE Peaks

Hg19::chr11:5705095..5705101,+	p@chr11:5705095..5705101 +
Hg19::chr17:32580142..32580147,+	p@chr17:32580142..32580147 +
Hg19::chr17:7747016..7747035,+	p@chr17:7747016..7747035 +
Hg19::chr17:7748946..7748974,+	p1@AB383855
Hg19::chr17:7749478..7749496,+	p@chr17:7749478..7749496 +
Hg19::chr17:7750261..7750276,+	p@chr17:7750261..7750276 +
Hg19::chr17:7750417..7750437,+	p10@KDM6B
Hg19::chr1:186649543..186649563,-	p1@PTGS2
Hg19::chr1:31205338..31205351,-	p5@LAPTM5
Hg19::chr2:9695787..9695813,-	p3@ADAM17
Hg19::chr2:9695820..9695831,-	p5@ADAM17
Hg19::chr3:10291107..10291123,-	p1@BC009749
Hg19::chr5:148206163..148206201,+	p1@ADRB2
Hg19::chr5:75839007..75839024,+	p@chr5:75839007..75839024 +
Hg19::chr6:144127704..144127730,+	p1@ENST00000545614
Hg19::chr6:2889928..2889934,-	p@chr6:2889928..2889934 -
Hg19::chrX:110924878..110924902,+	p3@ALG13

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0031347	regulation of defense response	0.000978689551586044
GO:0050727	regulation of inflammatory response	0.000978689551586044
GO:0048583	regulation of response to stimulus	0.00108557781968457
GO:0048589	developmental growth	0.00108557781968457
GO:0008217	regulation of blood pressure	0.00193438366969393
GO:0044459	plasma membrane part	0.00308260397451496
GO:0048636	positive regulation of muscle development	0.00308260397451496
GO:0048631	regulation of skeletal muscle growth	0.00308260397451496
GO:0004941	beta2-adrenergic receptor activity	0.00308260397451496
GO:0002032	arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway	0.00308260397451496
GO:0004577	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	0.00308260397451496
GO:0048638	regulation of developmental growth	0.00308260397451496
GO:0019371	cyclooxygenase pathway	0.00308260397451496
GO:0051927	negative regulation of calcium ion transport via voltage-gated calcium channel	0.00308260397451496
GO:0048630	skeletal muscle growth	0.00308260397451496
GO:0048639	positive regulation of developmental growth	0.00308260397451496
GO:0048643	positive regulation of skeletal muscle development	0.00308260397451496
GO:0048633	positive regulation of skeletal muscle growth	0.00308260397451496
GO:0008015	blood circulation	0.00382645550491927
GO:0003013	circulatory system process	0.00382645550491927
GO:0002021	response to dietary excess	0.00382645550491927
GO:0048641	regulation of skeletal muscle development	0.00382645550491927
GO:0051930	regulation of sensory perception of pain	0.00382645550491927
GO:0051380	norepinephrine binding	0.00382645550491927
GO:0044246	regulation of multicellular organismal metabolic process	0.00382645550491927
GO:0002025	norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure	0.00382645550491927
GO:0044253	positive regulation of multicellular organismal metabolic process	0.00382645550491927
GO:0002024	diet induced thermogenesis	0.00382645550491927
GO:0051931	regulation of sensory perception	0.00382645550491927
GO:0005764	lysosome	0.0040595369483209
GO:0000323	lytic vacuole	0.0040595369483209
GO:0007171	transmembrane receptor protein tyrosine kinase activation (dimerization)	0.0040595369483209
GO:0004666	prostaglandin-endoperoxide synthase activity	0.0040595369483209
GO:0051926	negative regulation of calcium ion transport	0.0040595369483209
GO:0022401	adaptation of signaling pathway	0.0040595369483209
GO:0051925	regulation of calcium ion transport via voltage-gated calcium channel	0.0040595369483209
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway	0.0040595369483209
GO:0045932	negative regulation of muscle contraction	0.0040595369483209
GO:0048634	regulation of muscle development	0.0040595369483209
GO:0045986	negative regulation of smooth muscle contraction	0.0040595369483209
GO:0030501	positive regulation of bone mineralization	0.0040595369483209
GO:0005773	vacuole	0.00414753281572236
GO:0005737	cytoplasm	0.0041869488270513
GO:0005887	integral to plasma membrane	0.0041869488270513
GO:0031226	intrinsic to plasma membrane	0.0041869488270513
GO:0002028	regulation of sodium ion transport	0.0041869488270513
GO:0031649	heat generation	0.0041869488270513
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	0.0041869488270513
GO:0043271	negative regulation of ion transport	0.0041869488270513
GO:0040015	negative regulation of multicellular organism growth	0.0041869488270513
GO:0045909	positive regulation of vasodilation	0.0041869488270513
GO:0019369	arachidonic acid metabolic process	0.0041869488270513
GO:0004939	beta-adrenergic receptor activity	0.0041869488270513
GO:0006954	inflammatory response	0.00454703326356174
GO:0005886	plasma membrane	0.00454703326356174
GO:0042640	anagen	0.00454703326356174
GO:0003085	negative regulation of systemic arterial blood pressure	0.00454703326356174
GO:0030259	lipid glycosylation	0.00454703326356174
GO:0045823	positive regulation of heart contraction	0.00454703326356174
GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	0.00454703326356174
GO:0050873	brown fat cell differentiation	0.00454703326356174
GO:0009888	tissue development	0.00479875604839804
GO:0008333	endosome to lysosome transport	0.0051203575259798
GO:0042312	regulation of vasodilation	0.0051203575259798
GO:0045778	positive regulation of ossification	0.0051203575259798
GO:0048820	hair follicle maturation	0.00570986645212989
GO:0046852	positive regulation of bone remodeling	0.00570986645212989
GO:0001659	thermoregulation	0.00570986645212989
GO:0009409	response to cold	0.00616266761559062
GO:0045776	negative regulation of blood pressure	0.00616266761559062
GO:0043410	positive regulation of MAPKKK cascade	0.00616266761559062
GO:0030279	negative regulation of ossification	0.00616266761559062
GO:0031348	negative regulation of defense response	0.00674522552025061
GO:0050728	negative regulation of inflammatory response	0.00674522552025061
GO:0001516	prostaglandin biosynthetic process	0.00728100014777047
GO:0046457	prostanoid biosynthetic process	0.00728100014777047
GO:0044444	cytoplasmic part	0.00728100014777047
GO:0009611	response to wounding	0.00729242213697446
GO:0030500	regulation of bone mineralization	0.00762495428690688
GO:0046851	negative regulation of bone remodeling	0.00762495428690688
GO:0051924	regulation of calcium ion transport	0.00811477290712111
GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal	0.00811477290712111
GO:0042127	regulation of cell proliferation	0.00840369474061683
GO:0043393	regulation of protein binding	0.00848023396141709
GO:0045453	bone resorption	0.00848023396141709
GO:0007041	lysosomal transport	0.00902583568068267
GO:0043408	regulation of MAPKKK cascade	0.00934401488107085
GO:0004935	adrenoceptor activity	0.00934401488107085
GO:0019233	sensory perception of pain	0.00934401488107085
GO:0042383	sarcolemma	0.00964137233616056
GO:0003073	regulation of systemic arterial blood pressure	0.00964137233616056
GO:0045444	fat cell differentiation	0.00964137233616056
GO:0043269	regulation of ion transport	0.00991988063841718
GO:0006693	prostaglandin metabolic process	0.00991988063841718
GO:0006692	prostanoid metabolic process	0.00991988063841718
GO:0022404	molting cycle process	0.00997764542160359
GO:0001942	hair follicle development	0.00997764542160359
GO:0022405	hair cycle process	0.00997764542160359
GO:0042633	hair cycle	0.00997764542160359
GO:0042303	molting cycle	0.00997764542160359
GO:0042311	vasodilation	0.0101262875003404
GO:0048871	multicellular organismal homeostasis	0.0101262875003404
GO:0001894	tissue homeostasis	0.0101262875003404
GO:0030278	regulation of ossification	0.0101262875003404
GO:0006952	defense response	0.0102343075644826
GO:0030282	bone mineralization	0.0102638586560294
GO:0008144	drug binding	0.0102638586560294
GO:0006940	regulation of smooth muscle contraction	0.0102638586560294
GO:0040014	regulation of multicellular organism growth	0.0106775508915968
GO:0045927	positive regulation of growth	0.0110836621600943
GO:0009605	response to external stimulus	0.0112791690858978
GO:0044236	multicellular organismal metabolic process	0.0112791690858978
GO:0007190	adenylate cyclase activation	0.0112791690858978
GO:0046850	regulation of bone remodeling	0.0115641987395527
GO:0035264	multicellular organism growth	0.0115641987395527
GO:0051241	negative regulation of multicellular organismal process	0.0117116812339498
GO:0031644	regulation of neurological process	0.0117116812339498
GO:0007034	vacuolar transport	0.0117116812339498
GO:0051349	positive regulation of lyase activity	0.0117116812339498
GO:0042562	hormone binding	0.0117116812339498
GO:0045762	positive regulation of adenylate cyclase activity	0.0117116812339498
GO:0031281	positive regulation of cyclase activity	0.0117116812339498
GO:0016599	caveolar membrane	0.0117116812339498
GO:0005624	membrane fraction	0.0117867676968731
GO:0051098	regulation of binding	0.0124093172192136
GO:0005901	caveola	0.0126493606741491
GO:0009266	response to temperature stimulus	0.0126493606741491
GO:0051051	negative regulation of transport	0.0134145121932217
GO:0008283	cell proliferation	0.0134322515493759
GO:0046456	icosanoid biosynthetic process	0.0140378287728118
GO:0044255	cellular lipid metabolic process	0.0140378287728118
GO:0030424	axon	0.0142643319981669
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	0.014988085910246
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.0152885631121562
GO:0030425	dendrite	0.0155845405578184
GO:0006937	regulation of muscle contraction	0.0157602334413733
GO:0006939	smooth muscle contraction	0.0157602334413733
GO:0016197	endosome transport	0.0160333098829645
GO:0045761	regulation of adenylate cyclase activity	0.0160333098829645
GO:0006898	receptor-mediated endocytosis	0.0160333098829645
GO:0031279	regulation of cyclase activity	0.0160333098829645
GO:0035150	regulation of tube size	0.0160333098829645
GO:0050880	regulation of blood vessel size	0.0160333098829645
GO:0051339	regulation of lyase activity	0.0160333098829645
GO:0008016	regulation of heart contraction	0.0160333098829645
GO:0003018	vascular process in circulatory system	0.0163016636746157
GO:0043176	amine binding	0.0165663221137575
GO:0008375	acetylglucosaminyltransferase activity	0.0168273601100729
GO:0000267	cell fraction	0.0168923916912742
GO:0005783	endoplasmic reticulum	0.0169249719079181
GO:0003015	heart process	0.0171107214720378
GO:0060047	heart contraction	0.0171107214720378
GO:0006629	lipid metabolic process	0.0178474284798399
GO:0006690	icosanoid metabolic process	0.0178474284798399
GO:0007219	Notch signaling pathway	0.0178474284798399
GO:0065008	regulation of biological quality	0.0179568193605684
GO:0005765	lysosomal membrane	0.0179714160513918
GO:0030258	lipid modification	0.0182067513995556
GO:0021700	developmental maturation	0.0184390856486435
GO:0044424	intracellular part	0.0190150870897525
GO:0000187	activation of MAPK activity	0.0195797588639124
GO:0045926	negative regulation of growth	0.0208195291182241
GO:0005774	vacuolar membrane	0.0210297736412811
GO:0044437	vacuolar part	0.0215732462313401
GO:0043406	positive regulation of MAP kinase activity	0.0219124412563559
GO:0008227	amine receptor activity	0.0219124412563559
GO:0007519	skeletal muscle development	0.0219124412563559
GO:0004601	peroxidase activity	0.0219124412563559
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	0.0219124412563559
GO:0051094	positive regulation of developmental process	0.0219780875876593
GO:0016324	apical plasma membrane	0.0219780875876593
GO:0043623	cellular protein complex assembly	0.0221703307430152
GO:0048523	negative regulation of cellular process	0.0228002364767809
GO:0048513	organ development	0.0228235872070181
GO:0006633	fatty acid biosynthetic process	0.0230480433826354
GO:0044425	membrane part	0.0234259517225252
GO:0048519	negative regulation of biological process	0.0240198556243217
GO:0051213	dioxygenase activity	0.0243764184368213
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.0243764184368213
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0245463966944457
GO:0043005	neuron projection	0.0247144608941831
GO:0006950	response to stress	0.0249086842099581
GO:0016053	organic acid biosynthetic process	0.0249088586627779
GO:0046394	carboxylic acid biosynthetic process	0.0249088586627779
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0249364330664341
GO:0035239	tube morphogenesis	0.0249364330664341
GO:0045177	apical part of cell	0.025390642816825
GO:0019933	cAMP-mediated signaling	0.0254340205500935
GO:0014706	striated muscle development	0.0254340205500935
GO:0001503	ossification	0.0254340205500935
GO:0031214	biomineral formation	0.0254340205500935
GO:0043405	regulation of MAP kinase activity	0.0267312696456385
GO:0046849	bone remodeling	0.0274457487539909
GO:0032403	protein complex binding	0.0287179184066142
GO:0009968	negative regulation of signal transduction	0.0293936900008597
GO:0051240	positive regulation of multicellular organismal process	0.0293936900008597
GO:0048771	tissue remodeling	0.0293936900008597
GO:0043235	receptor complex	0.0304749358152983
GO:0051049	regulation of transport	0.0304749358152983
GO:0005622	intracellular	0.0306441670925344
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.031919692513808
GO:0035295	tube development	0.031919692513808
GO:0006979	response to oxidative stress	0.0325711211180107
GO:0019935	cyclic-nucleotide-mediated signaling	0.0329477699037435
GO:0043231	intracellular membrane-bound organelle	0.0330240936432405
GO:0043227	membrane-bound organelle	0.0330240936432405
GO:0051179	localization	0.0339231025257245
GO:0003008	system process	0.0339231025257245
GO:0008544	epidermis development	0.0355591560521856
GO:0008194	UDP-glycosyltransferase activity	0.0360861562817729
GO:0048731	system development	0.0360861562817729
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.0360861562817729
GO:0045860	positive regulation of protein kinase activity	0.0364292355072501
GO:0033674	positive regulation of kinase activity	0.037023933710286
GO:0042165	neurotransmitter binding	0.0371054595085623
GO:0007398	ectoderm development	0.0371862005739715
GO:0051347	positive regulation of transferase activity	0.0372661677579912
GO:0000165	MAPKKK cascade	0.0378455823254122
GO:0009967	positive regulation of signal transduction	0.0384194404557652
GO:0042803	protein homodimerization activity	0.0394830124228228
GO:0005792	microsome	0.0402899138883853
GO:0003012	muscle system process	0.0404792835458063
GO:0006936	muscle contraction	0.0404792835458063
GO:0009628	response to abiotic stimulus	0.0404792835458063
GO:0042598	vesicular fraction	0.041266610787076
GO:0007517	muscle development	0.041805932616859
GO:0006814	sodium ion transport	0.0418612878776171
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.042445128009613
GO:0043413	biopolymer glycosylation	0.042445128009613
GO:0016020	membrane	0.042774578519125
GO:0006816	calcium ion transport	0.0434886333429926
GO:0006631	fatty acid metabolic process	0.0451728489267306
GO:0005768	endosome	0.0454446066848645
GO:0010324	membrane invagination	0.0459808557273375
GO:0006897	endocytosis	0.0459808557273375
GO:0004222	metalloendopeptidase activity	0.0460157287143691
GO:0040008	regulation of growth	0.0465076206679614
GO:0001501	skeletal development	0.0481328068956095
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0481579159595137
GO:0048856	anatomical structure development	0.0485216815438028

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
classical monocyte	8.61e-55	42
CD14-positive, CD16-negative classical monocyte	8.61e-55	42
defensive cell	8.75e-51	48
phagocyte	8.75e-51	48
myeloid leukocyte	1.12e-48	72
granulocyte monocyte progenitor cell	1.10e-46	67
myeloid lineage restricted progenitor cell	1.87e-45	66
macrophage dendritic cell progenitor	1.71e-41	61
monopoietic cell	3.11e-41	59
monocyte	3.11e-41	59
monoblast	3.11e-41	59
promonocyte	3.11e-41	59
leukocyte	1.94e-38	136
hematopoietic lineage restricted progenitor cell	4.26e-34	120
nongranular leukocyte	4.43e-32	115
myeloid cell	5.45e-30	108
common myeloid progenitor	5.45e-30	108
hematopoietic stem cell	1.38e-29	168
angioblastic mesenchymal cell	1.38e-29	168
hematopoietic cell	6.50e-29	177
hematopoietic oligopotent progenitor cell	3.03e-26	161
hematopoietic multipotent progenitor cell	3.03e-26	161
stuff accumulating cell	2.18e-25	87
mesenchymal cell	5.67e-10	354
connective tissue cell	9.71e-10	361
intermediate monocyte	1.56e-08	9
CD14-positive, CD16-positive monocyte	1.56e-08	9
histamine secreting cell	7.88e-08	5
biogenic amine secreting cell	7.88e-08	5
granulocytopoietic cell	7.88e-08	5
mast cell	7.88e-08	5
mast cell progenitor	7.88e-08	5
basophil mast progenitor cell	7.88e-08	5
motile cell	1.66e-07	386

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.69e-44	98
blood island	3.69e-44	98
bone marrow	2.20e-42	76
hemolymphoid system	1.81e-39	108
bone element	6.18e-38	82
immune system	5.53e-37	93
skeletal element	3.00e-34	90
skeletal system	5.35e-29	100
lateral plate mesoderm	2.05e-22	203
mesoderm	2.86e-14	315
mesoderm-derived structure	2.86e-14	315
presumptive mesoderm	2.86e-14	315
musculoskeletal system	2.95e-11	167
connective tissue	2.63e-09	371

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.