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Coexpression cluster:C3942

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Full id: C3942_Mast_CD14_CD4_CD8_Natural_Eosinophils_Basophils



Phase1 CAGE Peaks

Hg19::chr1:224033095..224033112,-p@chr1:224033095..224033112
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Hg19::chr1:224033119..224033129,-p@chr1:224033119..224033129
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Hg19::chr2:197127963..197127981,-p@chr2:197127963..197127981
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte3.92e-49136
hematopoietic cell1.67e-43177
hematopoietic stem cell1.59e-41168
angioblastic mesenchymal cell1.59e-41168
myeloid leukocyte1.70e-4172
granulocyte monocyte progenitor cell2.01e-3767
hematopoietic lineage restricted progenitor cell4.24e-35120
hematopoietic oligopotent progenitor cell4.14e-34161
hematopoietic multipotent progenitor cell4.14e-34161
myeloid lineage restricted progenitor cell1.76e-3366
classical monocyte4.85e-3342
CD14-positive, CD16-negative classical monocyte4.85e-3342
myeloid cell5.30e-32108
common myeloid progenitor5.30e-32108
nongranular leukocyte9.93e-30115
macrophage dendritic cell progenitor1.51e-2961
defensive cell6.02e-2848
phagocyte6.02e-2848
monopoietic cell1.78e-2659
monocyte1.78e-2659
monoblast1.78e-2659
promonocyte1.78e-2659
intermediate monocyte7.18e-239
CD14-positive, CD16-positive monocyte7.18e-239
mesenchymal cell3.53e-14354
circulating cell6.58e-146
connective tissue cell1.37e-13361
histamine secreting cell4.35e-135
biogenic amine secreting cell4.35e-135
granulocytopoietic cell4.35e-135
mast cell4.35e-135
mast cell progenitor4.35e-135
basophil mast progenitor cell4.35e-135
dendritic cell2.38e-1210
stuff accumulating cell3.68e-1287
motile cell1.56e-11386
CD4-positive, alpha-beta T cell7.78e-116
stem cell4.59e-10441
multi fate stem cell1.27e-09427
immature conventional dendritic cell1.63e-095
common dendritic progenitor1.63e-095
somatic stem cell2.86e-09433
natural killer cell8.47e-093
pro-NK cell8.47e-093
conventional dendritic cell1.35e-088
basophil1.51e-083
non-classical monocyte1.63e-083
CD14-low, CD16-positive monocyte1.63e-083
granulocyte5.77e-088
mature alpha-beta T cell5.89e-0818
alpha-beta T cell5.89e-0818
immature T cell5.89e-0818
mature T cell5.89e-0818
immature alpha-beta T cell5.89e-0818
blood cell7.27e-0811
plasmacytoid dendritic cell7.61e-083
single nucleate cell8.99e-083
mononuclear cell8.99e-083
endocrine cell4.71e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system5.24e-4098
blood island5.24e-4098
hemolymphoid system3.83e-35108
bone marrow7.78e-3476
immune system8.07e-3193
bone element1.30e-3082
skeletal element5.53e-2790
skeletal system2.86e-23100
lateral plate mesoderm1.34e-15203
connective tissue8.61e-13371
musculoskeletal system7.47e-11167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199734.258097958807540.01295179875054610.0462626255928138



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.