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Coexpression cluster:C3456

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Full id: C3456_Basophils_Eosinophils_Mast_CD14_CD34_Natural_CD8



Phase1 CAGE Peaks

Hg19::chr14:75744049..75744066,+p@chr14:75744049..75744066
+
Hg19::chr1:110438789..110438831,+p1@BC015716
Hg19::chr20:4795556..4795568,+p@chr20:4795556..4795568
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
myeloid leukocyte2.34e-8372
classical monocyte7.67e-7942
CD14-positive, CD16-negative classical monocyte7.67e-7942
leukocyte1.07e-75136
defensive cell1.60e-6748
phagocyte1.60e-6748
granulocyte monocyte progenitor cell1.70e-6467
hematopoietic stem cell8.31e-64168
angioblastic mesenchymal cell8.31e-64168
myeloid lineage restricted progenitor cell1.01e-6266
hematopoietic cell1.13e-59177
macrophage dendritic cell progenitor5.71e-5861
monopoietic cell2.34e-5759
monocyte2.34e-5759
monoblast2.34e-5759
promonocyte2.34e-5759
myeloid cell2.60e-57108
common myeloid progenitor2.60e-57108
hematopoietic oligopotent progenitor cell5.98e-55161
hematopoietic multipotent progenitor cell5.98e-55161
hematopoietic lineage restricted progenitor cell6.21e-54120
nongranular leukocyte6.09e-52115
stuff accumulating cell4.05e-3287
mesenchymal cell5.87e-21354
granulocyte7.98e-218
connective tissue cell3.31e-20361
motile cell1.46e-17386
intermediate monocyte2.83e-169
CD14-positive, CD16-positive monocyte2.83e-169
blood cell1.12e-1411
multi fate stem cell2.45e-14427
stem cell4.98e-14441
somatic stem cell6.81e-14433
basophil3.52e-093
histamine secreting cell4.55e-095
biogenic amine secreting cell4.55e-095
granulocytopoietic cell4.55e-095
mast cell4.55e-095
mast cell progenitor4.55e-095
basophil mast progenitor cell4.55e-095
natural killer cell8.47e-093
pro-NK cell8.47e-093
neutrophil2.43e-083
single nucleate cell5.44e-083
mononuclear cell5.44e-083
mature alpha-beta T cell2.97e-0718
alpha-beta T cell2.97e-0718
immature T cell2.97e-0718
mature T cell2.97e-0718
immature alpha-beta T cell2.97e-0718
plasmacytoid dendritic cell3.08e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.54e-5898
blood island2.54e-5898
bone marrow4.16e-5876
bone element6.24e-5382
hemolymphoid system1.34e-51108
immune system2.46e-4793
skeletal element4.27e-4790
skeletal system4.13e-41100
lateral plate mesoderm8.62e-21203
musculoskeletal system1.50e-19167
connective tissue3.51e-19371
mesoderm1.15e-08315
mesoderm-derived structure1.15e-08315
presumptive mesoderm1.15e-08315


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195834.988179094810140.008056488137383440.0319794597157155
ELF1#199734.258097958807540.01295179875054610.0461112292383938
FOXA2#3170216.42030916844350.004810682352105480.0225838474478152



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.