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Coexpression cluster:C2992

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Full id: C2992_Mast_CD4_immature_CD8_Natural_CD19_Basophils



Phase1 CAGE Peaks

Hg19::chr10:135121488..135121501,+p8@ZNF511
Hg19::chr11:66386629..66386638,-p@chr11:66386629..66386638
-
Hg19::chr1:6419175..6419204,+p@chr1:6419175..6419204
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.15e-22136
hematopoietic stem cell6.85e-22168
angioblastic mesenchymal cell6.85e-22168
hematopoietic cell2.56e-20177
hematopoietic oligopotent progenitor cell2.72e-20161
hematopoietic multipotent progenitor cell2.72e-20161
hematopoietic lineage restricted progenitor cell4.37e-18120
CD4-positive, alpha-beta T cell6.08e-166
mature alpha-beta T cell1.47e-1518
alpha-beta T cell1.47e-1518
immature T cell1.47e-1518
mature T cell1.47e-1518
immature alpha-beta T cell1.47e-1518
lymphoid lineage restricted progenitor cell2.69e-1452
lymphocyte5.92e-1453
common lymphoid progenitor5.92e-1453
nucleate cell2.63e-1355
nongranular leukocyte3.85e-13115
basophil8.25e-123
natural killer cell1.37e-113
pro-NK cell1.37e-113
T cell1.05e-1025
pro-T cell1.05e-1025
intermediate monocyte1.01e-099
CD14-positive, CD16-positive monocyte1.01e-099
CD1a-positive Langerhans cell1.39e-082
immature CD1a-positive Langerhans cell1.39e-082
myeloid cell2.99e-08108
common myeloid progenitor2.99e-08108
mesenchymal cell3.19e-08354
connective tissue cell6.97e-08361
histamine secreting cell1.08e-075
biogenic amine secreting cell1.08e-075
granulocytopoietic cell1.08e-075
mast cell1.08e-075
mast cell progenitor1.08e-075
basophil mast progenitor cell1.08e-075
Langerhans cell4.76e-075
Uber Anatomy
Ontology termp-valuen
connective tissue4.83e-08371
bone marrow4.81e-0776


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.