Coexpression cluster:C2354

Full id: C2354_CD14_Eosinophils_CD19_Reticulocytes_CD4_Smooth_Neutrophils

Phase1 CAGE Peaks

Hg19::chr15:89182156..89182177,+	p6@ISG20
Hg19::chr15:89182178..89182202,+	p4@ISG20
Hg19::chr15:89182208..89182225,+	p5@ISG20
Hg19::chr15:89182240..89182265,+	p1@ISG20

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	2.87e-34	136
nongranular leukocyte	7.55e-32	115
hematopoietic lineage restricted progenitor cell	6.05e-28	120
nucleate cell	1.21e-21	55
hematopoietic cell	4.10e-21	177
hematopoietic stem cell	6.68e-21	168
angioblastic mesenchymal cell	6.68e-21	168
lymphocyte	2.25e-20	53
common lymphoid progenitor	2.25e-20	53
lymphoid lineage restricted progenitor cell	3.59e-20	52
classical monocyte	2.26e-19	42
CD14-positive, CD16-negative classical monocyte	2.26e-19	42
hematopoietic oligopotent progenitor cell	4.44e-19	161
hematopoietic multipotent progenitor cell	4.44e-19	161
defensive cell	2.45e-14	48
phagocyte	2.45e-14	48
lymphocyte of B lineage	2.48e-12	24
pro-B cell	2.48e-12	24
myeloid leukocyte	1.40e-11	72
macrophage dendritic cell progenitor	1.59e-11	61
monopoietic cell	3.61e-11	59
monocyte	3.61e-11	59
monoblast	3.61e-11	59
promonocyte	3.61e-11	59
mature alpha-beta T cell	4.88e-10	18
alpha-beta T cell	4.88e-10	18
immature T cell	4.88e-10	18
mature T cell	4.88e-10	18
immature alpha-beta T cell	4.88e-10	18
myeloid lineage restricted progenitor cell	2.79e-09	66
granulocyte monocyte progenitor cell	6.05e-09	67
B cell	1.46e-08	14
T cell	3.70e-08	25
pro-T cell	3.70e-08	25
CD8-positive, alpha-beta T cell	9.49e-07	11

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	2.26e-14	108
hematopoietic system	4.82e-14	98
blood island	4.82e-14	98
immune system	6.30e-09	93
blood	9.28e-09	15
haemolymphatic fluid	9.28e-09	15
organism substance	9.28e-09	15

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	4	22.4631745260087	3.92475754624726e-06	0.000127257917843067
BATF#10538	4	24.3578017923036	2.83869198020713e-06	9.7748154210634e-05
BCL11A#53335	4	28.3694551036071	1.542446414682e-06	5.88784945551804e-05
BCL3#602	4	34.5471028037383	7.01262157705428e-07	3.14601024435555e-05
BHLHE40#8553	4	44.8718135469774	2.46312701995675e-07	1.28238545781288e-05
BRCA1#672	4	20.1842306432238	6.02116732184487e-06	0.000179413607396906
CCNT2#905	4	6.33620157696263	0.000620310058721564	0.00511685982330159
CEBPB#1051	4	7.97114762582482	0.000247638578809083	0.0026781739186333
CTCF#10664	4	5.36025637307503	0.00121114538164362	0.0081659659466416
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00996174037967414
EBF1#1879	4	8.906466846569	0.0001588790747201	0.00199485112823906
EGR1#1958	4	4.98817909481014	0.00161501150007605	0.0101370386475415
ELF1#1997	4	4.25809795880754	0.00304152556578124	0.0160764152317742
ELK4#2005	4	16.235681658468	1.43847748454449e-05	0.000343154751046921
EP300#2033	4	6.7739417262232	0.000474845982144264	0.00433841654528605
FOS#2353	4	8.9979553088944	0.000152514771116863	0.00194724818834646
FOSL1#8061	4	39.713579716373	4.01511434669553e-07	1.93777507973445e-05
FOSL2#2355	4	16.9302006045617	1.2165416097647e-05	0.000303232432415789
FOXA1#3169	4	11.0814197493855	6.62943068949433e-05	0.00106962940179221
FOXA2#3170	4	24.6304637526652	2.71504128667089e-06	9.41734297371706e-05
GABPB1#2553	4	7.06768383618217	0.000400687686442317	0.00390040276673959
GATA1#2623	4	13.5603081438004	2.95627390049268e-05	0.000613695666653856
GATA2#2624	4	12.744931733554	3.78864877853583e-05	0.000721259004341057
GTF2F1#2962	4	12.7396608767577	3.79492332235515e-05	0.000716964538464996
HDAC2#3066	4	13.4156202366263	3.0859005065161e-05	0.000626045771173339
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0185809153709775
HMGN3#9324	4	8.17854772335059	0.000223457028444047	0.00247903426743869
IRF1#3659	4	7.6371637535639	0.000293885399618549	0.00307145974689899
IRF4#3662	4	21.9145126867441	4.33289161192893e-06	0.000136261025913353
JUN#3725	4	12.5128291923363	4.07770316866756e-05	0.000742194564713265
JUNB#3726	4	30.6106326598211	1.13787152942193e-06	4.65302132581431e-05
JUND#3727	4	6.99466394187103	0.00041768421781858	0.0039126847273078
MAX#4149	4	6.45255550900712	0.000576761319564549	0.00485073083056868
MEF2A#4205	4	18.7432309096441	8.0978922767748e-06	0.000224333095887025
MEF2C#4208	4	41.3113544926241	3.42889182145094e-07	1.69800869104085e-05
MXI1#4601	4	9.9615716287593	0.000101522475495045	0.00142225430157303
MYC#4609	4	5.2222818716094	0.00134430939527274	0.00886856982710437
NANOG#79923	4	29.2447784810127	1.36586687657858e-06	5.32672780892422e-05
NFKB1#4790	4	5.48806342419384	0.00110219956630198	0.00767417470033415
NR3C1#2908	4	14.973023331173	1.98868032687801e-05	0.000442376538144435
PAX5#5079	4	6.66956553117783	0.000505277416948326	0.00443488260767007
POU2F2#5452	4	9.10612405774252	0.00014539566517493	0.00188282428706813
RAD21#5885	4	10.3550338954563	8.6948481184721e-05	0.00129227443097354
REST#5978	4	9.65002871612802	0.000115282561421917	0.00156852467852314
RFX5#5993	4	12.0479108271951	4.74457429336527e-05	0.00082613970427605
RXRA#6256	4	20.0746171391333	6.1537798808435e-06	0.000181963368339585
SIN3A#25942	4	5.40888472681514	0.00116817238488516	0.00795376202523116
SMARCC1#6599	3	32.7475194897236	4.71941722862287e-05	0.000824784497891807
SMC3#9126	4	15.0449328449328	1.95092670935632e-05	0.000437331690488226
SP1#6667	4	5.6983813781409	0.000948260606533398	0.00683568397886123
STAT1#6772	4	20.7065874971992	5.43610708103893e-06	0.000165185216012984
STAT2#6773	4	65.2637711864407	5.50053512607993e-08	3.46275098271646e-06
STAT3#6774	4	10.5194649971542	8.16377768286615e-05	0.00123032724014554
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0321813493073978
TAF7#6879	4	11.4330694049239	5.85061525419808e-05	0.000968048806294666
TAL1#6886	4	29.8686166774402	1.25525650806991e-06	5.03447520915181e-05
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0243881840570637
TCF12#6938	4	10.6344649021864	7.8163066689251e-05	0.0011995991949976
TCF7L2#6934	4	10.7701765631373	7.42969445082454e-05	0.00115280026556182
TFAP2C#7022	4	10.8092286098602	7.32289634782688e-05	0.00114473278202468
THAP1#55145	4	31.3691446028513	1.03171810326891e-06	4.31524257057676e-05
USF1#7391	4	6.36149927720796	0.000610501139914083	0.0050752311192778
USF2#7392	4	12.9921973850696	3.50833029870167e-05	0.000680799903504466
YY1#7528	4	4.91117074985386	0.0017187183805544	0.0106718923273913
ZEB1#6935	4	16.8884320175439	1.22862303393937e-05	0.000303994695668311
ZNF263#10127	4	8.22184163701068	0.000218787118095832	0.00248530648540468

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.