Coexpression cluster:C2288

Full id: C2288_mesothelioma_colon_small_Intestinal_Prostate_CD14_Macrophage

Phase1 CAGE Peaks

Hg19::chr14:23284561..23284595,-	p2@SLC7A7
Hg19::chr14:23284599..23284616,-	p4@SLC7A7
Hg19::chr14:23284630..23284650,-	p1@SLC7A7
Hg19::chr14:23284675..23284684,-	p11@SLC7A7

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
monopoietic cell	5.69e-38	59
monocyte	5.69e-38	59
monoblast	5.69e-38	59
promonocyte	5.69e-38	59
macrophage dendritic cell progenitor	1.23e-35	61
defensive cell	2.72e-34	48
phagocyte	2.72e-34	48
myeloid leukocyte	2.02e-33	72
myeloid lineage restricted progenitor cell	1.78e-30	66
granulocyte monocyte progenitor cell	1.51e-29	67
classical monocyte	2.16e-29	42
CD14-positive, CD16-negative classical monocyte	2.16e-29	42
nongranular leukocyte	8.52e-19	115
leukocyte	1.57e-16	136
myeloid cell	5.76e-15	108
common myeloid progenitor	5.76e-15	108
stuff accumulating cell	1.66e-14	87
hematopoietic lineage restricted progenitor cell	3.79e-14	120
hematopoietic stem cell	2.15e-09	168
angioblastic mesenchymal cell	2.15e-09	168
hematopoietic cell	6.46e-09	177
hematopoietic oligopotent progenitor cell	2.21e-08	161
hematopoietic multipotent progenitor cell	2.21e-08	161
intermediate monocyte	5.56e-08	9
CD14-positive, CD16-positive monocyte	5.56e-08	9

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.05e-27	98
blood island	3.05e-27	98
hemolymphoid system	5.37e-24	108
bone marrow	9.76e-24	76
lateral plate mesoderm	3.68e-23	203
immune system	5.92e-20	93
bone element	7.88e-20	82
mesoderm	1.89e-19	315
mesoderm-derived structure	1.89e-19	315
presumptive mesoderm	1.89e-19	315
skeletal element	1.37e-15	90
musculoskeletal system	3.28e-12	167
skeletal system	7.44e-12	100
embryo	2.55e-08	592
germ layer	2.85e-08	560
germ layer / neural crest	2.85e-08	560
embryonic tissue	2.85e-08	560
presumptive structure	2.85e-08	560
germ layer / neural crest derived structure	2.85e-08	560
epiblast (generic)	2.85e-08	560
developing anatomical structure	3.18e-08	581
adult organism	9.05e-08	114
embryonic structure	1.01e-07	564
organ	3.19e-07	503
tissue	7.36e-07	773

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BCLAF1#9774	2	10.8263238050609	0.0120220381643258	0.0436492141089526
CEBPB#1051	4	7.97114762582482	0.000247638578809083	0.0026770650587146
HNF4A#3172	4	23.1322903629537	3.48990320893214e-06	0.000115378917770707
HNF4G#3174	4	28.7534225264468	1.46167379934821e-06	5.65810785508258e-05
MAFK#7975	4	27.1007331378299	1.85228494563408e-06	6.84539233676851e-05

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.