Coexpression cluster:C2175

Full id: C2175_CD14_CD14CD16_splenic_migratory_Peripheral_Basophils_Whole

Phase1 CAGE Peaks

Hg19::chr12:10124110..10124121,+	p2@CLEC12A
Hg19::chr4:38080384..38080414,+	p@chr4:38080384..38080414 +
Hg19::chr5:54070798..54070804,+	p@chr5:54070798..54070804 +
Hg19::chr9:136343729..136343751,-	p4@SLC2A6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005355	glucose transmembrane transporter activity	0.0164759143109795
GO:0015149	hexose transmembrane transporter activity	0.0164759143109795
GO:0015145	monosaccharide transmembrane transporter activity	0.0164759143109795
GO:0005351	sugar:hydrogen ion symporter activity	0.022368731471487
GO:0051119	sugar transmembrane transporter activity	0.022368731471487
GO:0015144	carbohydrate transmembrane transporter activity	0.022368731471487
GO:0008643	carbohydrate transport	0.022368731471487
GO:0015293	symporter activity	0.0425894721577773

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
monopoietic cell	2.35e-81	59
monocyte	2.35e-81	59
monoblast	2.35e-81	59
promonocyte	2.35e-81	59
myeloid leukocyte	3.49e-79	72
macrophage dendritic cell progenitor	4.32e-78	61
myeloid lineage restricted progenitor cell	1.03e-75	66
defensive cell	1.00e-74	48
phagocyte	1.00e-74	48
granulocyte monocyte progenitor cell	2.66e-74	67
classical monocyte	2.97e-69	42
CD14-positive, CD16-negative classical monocyte	2.97e-69	42
leukocyte	7.17e-66	136
nongranular leukocyte	3.93e-63	115
myeloid cell	9.13e-57	108
common myeloid progenitor	9.13e-57	108
hematopoietic lineage restricted progenitor cell	1.03e-56	120
hematopoietic stem cell	6.69e-53	168
angioblastic mesenchymal cell	6.69e-53	168
hematopoietic oligopotent progenitor cell	4.86e-51	161
hematopoietic multipotent progenitor cell	4.86e-51	161
hematopoietic cell	3.08e-50	177
stuff accumulating cell	2.26e-35	87
intermediate monocyte	1.49e-16	9
CD14-positive, CD16-positive monocyte	1.49e-16	9
mesenchymal cell	1.24e-14	354
connective tissue cell	6.82e-14	361
motile cell	8.03e-12	386
multi fate stem cell	3.38e-09	427
stem cell	3.59e-09	441
somatic stem cell	9.20e-09	433
conventional dendritic cell	1.57e-07	8
macrophage	4.72e-07	6
non-classical monocyte	8.67e-07	3
CD14-low, CD16-positive monocyte	8.67e-07	3

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	2.73e-71	98
blood island	2.73e-71	98
hemolymphoid system	6.82e-71	108
immune system	2.73e-66	93
bone marrow	2.91e-63	76
bone element	3.03e-57	82
skeletal element	1.80e-50	90
skeletal system	3.76e-45	100
lateral plate mesoderm	8.74e-29	203
musculoskeletal system	1.77e-20	167
mesoderm	1.20e-13	315
mesoderm-derived structure	1.20e-13	315
presumptive mesoderm	1.20e-13	315
connective tissue	2.00e-13	371

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
HNF4A#3172	2	11.5661451814768	0.0105758568176249	0.0390625233475714

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.