MCL coexpression mm9:884

Phase1 CAGE Peaks

	Short description
Mm9::chr11:102342088..102342102,-	p@chr11:102342088..102342102 -
Mm9::chr11:29363676..29363691,+	p4@Ccdc88a
Mm9::chr11:29363735..29363749,+	p3@Ccdc88a
Mm9::chr11:77107497..77107501,+	p@chr11:77107497..77107501 +
Mm9::chr14:57291296..57291310,+	p2@Mphosph8
Mm9::chr14:57292752..57292765,+	p@chr14:57292752..57292765 +
Mm9::chr14:57293460..57293463,+	p@chr14:57293460..57293463 +
Mm9::chr19:60018977..60019003,-	p4@Rab11fip2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032148	activation of protein kinase B	0.00542376595628116
GO:0043422	protein kinase B binding	0.00542376595628116
GO:0006259	DNA metabolic process	0.029822540857081
GO:0006275	regulation of DNA replication	0.029822540857081
GO:0051052	regulation of DNA metabolic process	0.0356792078839629
GO:0032147	activation of protein kinase activity	0.0356792078839629
GO:0008017	microtubule binding	0.0356792078839629
GO:0006261	DNA-dependent DNA replication	0.0356792078839629
GO:0019901	protein kinase binding	0.0356792078839629
GO:0019900	kinase binding	0.0356792078839629
GO:0001932	regulation of protein amino acid phosphorylation	0.0356792078839629
GO:0033238	regulation of amine metabolic process	0.0356792078839629
GO:0006521	regulation of amino acid metabolic process	0.0356792078839629
GO:0015631	tubulin binding	0.0356792078839629
GO:0042325	regulation of phosphorylation	0.0356792078839629
GO:0051174	regulation of phosphorus metabolic process	0.0356792078839629
GO:0019220	regulation of phosphate metabolic process	0.0356792078839629
GO:0045860	positive regulation of protein kinase activity	0.0470658445862631
GO:0033674	positive regulation of kinase activity	0.0470658445862631
GO:0051347	positive regulation of transferase activity	0.0470658445862631
GO:0003682	chromatin binding	0.0470658445862631
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0470658445862631
GO:0031323	regulation of cellular metabolic process	0.0470658445862631
GO:0045859	regulation of protein kinase activity	0.0470658445862631
GO:0019222	regulation of metabolic process	0.0470658445862631
GO:0006333	chromatin assembly or disassembly	0.0470658445862631
GO:0043549	regulation of kinase activity	0.0470658445862631
GO:0019899	enzyme binding	0.0470658445862631
GO:0043085	positive regulation of catalytic activity	0.0470658445862631
GO:0006260	DNA replication	0.0470658445862631
GO:0051338	regulation of transferase activity	0.0470658445862631

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	6.05e-09	92
embryo	5.23e-08	320
occipital lobe	7.68e-08	10
visual cortex	7.68e-08	10
neocortex	7.68e-08	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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