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MCL coexpression mm9:519

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Phase1 CAGE Peaks

 Short description
Mm9::chr10:77815034..77815062,-p4@Agpat3
Mm9::chr16:91225691..91225700,+p5@Olig2
Mm9::chr16:91225808..91225824,+p1@Olig2
Mm9::chr16:91269972..91269978,+p3@Olig1
Mm9::chr16:91270004..91270023,+p1@Olig1
Mm9::chr16:91270091..91270143,+p2@Olig1
Mm9::chr5:33084895..33084903,-p5@Pisd
Mm9::chr6:120723567..120723597,+p1@Slc25a18
Mm9::chr6:120723602..120723604,+p3@Slc25a18
Mm9::chr6:120723629..120723642,+p2@Slc25a18
Mm9::chr6:120723651..120723654,+p4@Slc25a18
Mm9::chr6:85163894..85163900,-p@chr6:85163894..85163900
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Mm9::chr7:29551766..29551841,+p1@Sirt2
Mm9::chr9:119977381..119977409,-p1@Cx3cr1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0048663neuron fate commitment0.00328124834416348
GO:0044451nucleoplasm part0.0216479470319356
GO:0045165cell fate commitment0.0216479470319356
GO:0005654nucleoplasm0.0216479470319356
GO:0031981nuclear lumen0.0255129623200036
GO:0004609phosphatidylserine decarboxylase activity0.0255129623200036
GO:0031974membrane-enclosed lumen0.0255129623200036
GO:0043233organelle lumen0.0255129623200036
GO:0045892negative regulation of transcription, DNA-dependent0.029467491566657
GO:0016481negative regulation of transcription0.0338399603669903
GO:0005677chromatin silencing complex0.0338399603669903
GO:0044428nuclear part0.0338399603669903
GO:0045934negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0338399603669903
GO:0044446intracellular organelle part0.0338399603669903
GO:0044422organelle part0.0338399603669903
GO:0048709oligodendrocyte differentiation0.0338399603669903
GO:0030182neuron differentiation0.0338399603669903
GO:0031324negative regulation of cellular metabolic process0.0353489451883645
GO:0048699generation of neurons0.0353489451883645
GO:0006342chromatin silencing0.0353489451883645
GO:0031507heterochromatin formation0.0353489451883645
GO:0009892negative regulation of metabolic process0.035679063989088
GO:0022008neurogenesis0.035679063989088
GO:0045814negative regulation of gene expression, epigenetic0.035679063989088
GO:0003705RNA polymerase II transcription factor activity, enhancer binding0.0433619796683617
GO:0016585chromatin remodeling complex0.04388263289812
GO:0005667transcription factor complex0.0466304394042769
GO:0004950chemokine receptor activity0.0466304394042769
GO:0019956chemokine binding0.0466304394042769
GO:0001637G-protein chemoattractant receptor activity0.0466304394042769
GO:0016831carboxy-lyase activity0.0466304394042769
GO:0042552myelination0.0466304394042769
GO:0016458gene silencing0.0466304394042769
GO:0007272ensheathment of neurons0.0472096397336174
GO:0008366axon ensheathment0.0472096397336174
GO:0043234protein complex0.0492691316908081



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
nervous system2.28e-3875
central nervous system1.38e-3773
regional part of nervous system9.76e-3554
neural tube1.41e-3252
neural rod1.41e-3252
future spinal cord1.41e-3252
neural keel1.41e-3252
ectoderm-derived structure4.05e-3195
ectoderm4.05e-3195
presumptive ectoderm4.05e-3195
neurectoderm5.42e-2864
neural plate5.42e-2864
presumptive neural plate5.42e-2864
brain1.59e-2747
future brain1.59e-2747
gray matter9.58e-2734
regional part of brain1.43e-2646
ecto-epithelium2.13e-2373
anterior neural tube1.06e-2240
brain grey matter5.34e-2229
regional part of telencephalon5.34e-2229
telencephalon5.34e-2229
regional part of forebrain8.33e-2239
forebrain8.33e-2239
future forebrain8.33e-2239
pre-chordal neural plate1.20e-2049
cerebral cortex1.98e-1521
cerebral hemisphere1.98e-1521
pallium1.98e-1521
structure with developmental contribution from neural crest5.31e-1592
regional part of cerebral cortex3.22e-1317
occipital lobe2.75e-1010
visual cortex2.75e-1010
neocortex2.75e-1010
posterior neural tube3.33e-1012
chordal neural plate3.33e-1012
basal ganglion9.95e-088
nuclear complex of neuraxis9.95e-088
aggregate regional part of brain9.95e-088
collection of basal ganglia9.95e-088
cerebral subcortex9.95e-088
spinal cord5.47e-076
dorsal region element5.47e-076
dorsum5.47e-076


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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