MCL coexpression mm9:394

Phase1 CAGE Peaks

	Short description
Mm9::chr10:79579860..79579871,-	p@chr10:79579860..79579871 -
Mm9::chr11:115628094..115628110,+	p5@2310067B10Rik
Mm9::chr11:6192037..6192053,+	p11@Ogdh
Mm9::chr11:69760911..69760934,-	p@chr11:69760911..69760934 -
Mm9::chr11:95686473..95686493,+	p@chr11:95686473..95686493 +
Mm9::chr12:37833337..37833344,-	p@chr12:37833337..37833344 -
Mm9::chr15:101091097..101091115,+	p@chr15:101091097..101091115 +
Mm9::chr15:89256249..89256282,-	p1@Cpt1b
Mm9::chr16:43364103..43364130,+	p30@Zbtb20
Mm9::chr19:5848495..5848522,+	p1@ENSMUST00000135347 p1@uc012bhf.1
Mm9::chr1:182123606..182123623,-	p2@Adck3
Mm9::chr2:26465282..26465293,+	p@chr2:26465282..26465293 +
Mm9::chr5:114596684..114596724,+	p1@Acacb
Mm9::chr6:5446296..5446316,-	p1@Pdk4
Mm9::chr6:86466170..86466203,-	p2@uc009csb.1
Mm9::chr7:137696485..137696499,+	p@chr7:137696485..137696499 +
Mm9::chr7:146037793..146037814,-	p3@Mapk1ip1
Mm9::chr7:148086300..148086318,-	p1@Cox8b
Mm9::chr7:53152416..53152459,+	p1@Tmem143

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050164	oxoglutarate dehydrogenase (NADP+) activity	0.0203257535509281
GO:0005739	mitochondrion	0.0203257535509281
GO:0006006	glucose metabolic process	0.0203257535509281
GO:0009343	biotin carboxylase complex	0.0203257535509281
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	0.0203257535509281
GO:0015909	long-chain fatty acid transport	0.0203257535509281
GO:0009317	acetyl-CoA carboxylase complex	0.0203257535509281
GO:0004075	biotin carboxylase activity	0.0203257535509281
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	0.0203257535509281
GO:0003989	acetyl-CoA carboxylase activity	0.0203257535509281
GO:0030976	thiamin pyrophosphate binding	0.0203257535509281
GO:0019318	hexose metabolic process	0.0203257535509281
GO:0005996	monosaccharide metabolic process	0.0203257535509281
GO:0016416	O-palmitoyltransferase activity	0.0203257535509281
GO:0004095	carnitine O-palmitoyltransferase activity	0.0203257535509281
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	0.0203257535509281
GO:0015908	fatty acid transport	0.0212001878857225
GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	0.0212001878857225
GO:0018106	peptidyl-histidine phosphorylation	0.0212001878857225
GO:0006085	acetyl-CoA biosynthetic process	0.0212001878857225
GO:0016421	CoA carboxylase activity	0.0212001878857225
GO:0018202	peptidyl-histidine modification	0.0212001878857225
GO:0016406	carnitine O-acyltransferase activity	0.0212001878857225
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.0227498824205088
GO:0016885	ligase activity, forming carbon-carbon bonds	0.0227498824205088
GO:0004712	protein serine/threonine/tyrosine kinase activity	0.0249943931706218
GO:0032787	monocarboxylic acid metabolic process	0.0282512687771836
GO:0004673	protein histidine kinase activity	0.0289986381866018
GO:0031966	mitochondrial membrane	0.0341836849493751
GO:0044262	cellular carbohydrate metabolic process	0.0341836849493751
GO:0006066	alcohol metabolic process	0.0346510387827957
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	0.0354922136400253
GO:0005740	mitochondrial envelope	0.0357826276418746
GO:0016409	palmitoyltransferase activity	0.0357826276418746
GO:0044444	cytoplasmic part	0.0405003810754452
GO:0005741	mitochondrial outer membrane	0.0405003810754452
GO:0044429	mitochondrial part	0.0405003810754452
GO:0004129	cytochrome-c oxidase activity	0.0405003810754452
GO:0006090	pyruvate metabolic process	0.0405003810754452
GO:0016676	oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	0.0405003810754452
GO:0015002	heme-copper terminal oxidase activity	0.0405003810754452
GO:0016675	oxidoreductase activity, acting on heme group of donors	0.0405003810754452
GO:0031968	organelle outer membrane	0.0414331748193682
GO:0005975	carbohydrate metabolic process	0.0445371017946409
GO:0031975	envelope	0.0494077548759043
GO:0031967	organelle envelope	0.0494077548759043
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.0498917110559975

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	2.32e-09	18
heart	2.32e-09	18
primitive heart tube	2.32e-09	18
primary heart field	2.32e-09	18
anterior lateral plate mesoderm	2.32e-09	18
heart tube	2.32e-09	18
heart primordium	2.32e-09	18
cardiac mesoderm	2.32e-09	18
cardiogenic plate	2.32e-09	18
heart rudiment	2.32e-09	18
cardiovascular system	1.99e-08	23
circulatory system	1.99e-08	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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